Graduate Institute of Pharmacognosy

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output

2020

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., Mar 2020, In : Food and Function. 11, 3, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
Open Access

Hypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction

Chang, S. C., Liew, P. L., Ansar, M., Lin, S. Y., Wang, S. C., Hung, C. S., Chen, J. Y., Jain, S. & Lin, R. K., May 12 2020, In : Clinical Epigenetics. 12, 1, 67.

Research output: Contribution to journalArticle

Open Access

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., Jan 2020, In : Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Preparation and characterization of a novel swellable and floating gastroretentive drug delivery system (sfGRDDS) for enhanced oral bioavailability of nilotinib

Lin, H. L., Chen, L. C., Cheng, W. T., Cheng, W. J., Ho, H. O. & Sheu, M. T., Feb 2020, In : Pharmaceutics. 12, 2, 137.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
3 Citations (Scopus)
Open Access

Protective evaluation of compounds extracted from root of rhodiola rosea L. Against methylglyoxal-induced toxicity in a neuronal cell line

Wang, C. H., Safwan, S., Cheng, M. C., Liao, T. Y., Cheng, L. C., Chen, T. A., Kuo, Y. H., Lin, Y. F. & Lee, C. K., Jun 2020, In : Molecules. 25, 12, 2801.

Research output: Contribution to journalArticle

Open Access

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., Apr 15 2020, In : European Journal of Medicinal Chemistry. 192, p. 112193 112193.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., Nov 1 2019, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access
Open Access
3 Citations (Scopus)

Development of an inflammatory tissue-selective chimeric TNF receptor

Lee, C. J., Wang, C. C., Chen, M., Chuang, K. H., Cheng, T. L., Jian, T. Y., Wang, Y. M., Huang, T. H., Liao, K. W. & Tzou, S. C., Jan 1 2019, In : Cytokine. 113, p. 340-346 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficient identification of fungal antimicrobial principles by tandem MS and NMR database

Lee, M. S., Yang, Y. L., Wu, C. Y., Chen, Y. L., Lee, C. K., Tzean, S. S. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., Dec 4 2019, In : Biomolecules. 9, 12

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer

Lo, Y. W., Sheu, M. T., Chiang, W. H., Chiu, Y. L., Tu, C. M., Wang, W. Y., Wu, M. H., Wang, Y. C., Lu, M. & Ho, H. O., Mar 1 2019, In : Acta Biomaterialia. 86, p. 280-290 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Isolated compounds from turpinia formosana nakai induce ossification

Imtiyaz, Z., Wang, Y. F., Lin, Y. T., Liu, H. K. & Lee, M. H., Jul 1 2019, In : International Journal of Molecular Sciences. 20, 13, 3119.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Liposomal irinotecan for treatment of colorectal cancer in a preclinical model

Huang, J. R., Lee, M. H., Li, W. S. & Wu, H. C., Mar 1 2019, In : Cancers. 11, 3, 281.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 11 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Modulation of tumor stem cell characteristics by 17β-estradiol in human mesenchymal stem cells derived from ovarian endometrioma

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., May 2019, In : Taiwanese Journal of Obstetrics and Gynecology. 58, 3, p. 338-344 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

New abietane-type diterpenoids from the bark of cryptomeria japonica

Chang, C. I., Chen, J. J., Hsu, C., Chen, C. C., Cheng, W. Y., Wang, S. Y., Lee, C. K., Cheng, M. J. & Kuo, Y. H., Jan 1 2019, In : Natural Product Communications. 14, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Lin, R. K., Choong, C. Y., Hsu, W. H., Tai, C. J. & Tai, C. J., Jun 2019, In : African Health Sciences. 19, 2, p. 2156-2163 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

Lu, Y. C., Chuang, C. H., Chuang, K. H., Chen, I. J., Huang, B. C., Lee, W. H., Wang, H. E., Li, J. J., Cheng, Y. A., Cheng, K. W., Wang, J. Y., Hsieh, Y. C., Lin, W. W. & Cheng, T. L., Jun 1 2019, In : PLoS Biology. 17, 6, p. e3000286

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

Wang, C. C., Chen, H. F., Wu, J. Y. & Chen, L. G., Jan 21 2019, In : Molecules. 24, 2, 365.

Research output: Contribution to journalArticle

Open Access

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

Huang, S. W., Yang, H. Y., Huang, W. J., Chen, W. C., Yu, M. C., Wang, S. W., Hsu, Y. F. & Hsu, M. J., Nov 6 2019, In : Frontiers in Oncology. 9, 1188.

Research output: Contribution to journalArticle

Open Access
2018
1 Citation (Scopus)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., Mar 1 2018, In : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

Research output: Contribution to journalArticle

2 Citations (Scopus)
8 Citations (Scopus)

Bradycardia and hypotension from improper use of aconite root: A case report and brief review

Chou, P. Y., Wang, C. C., Tai, C. J., Yang, T. L. & Tang, Y. J., Oct 1 2018, In : Complementary Medicine Research. 25, 5, p. 338-343 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., Jan 4 2018, In : Oncogene. 37, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, In : British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
6 Citations (Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

2 Citations (Scopus)
12 Citations (Scopus)

Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates

Chen, Y. J., Chen, M., Hsieh, Y. C., Su, Y. C., Wang, C. H., Cheng, C. M., Kao, A. P., Wang, K. H., Cheng, J. J. & Chuang, K. H., Dec 1 2018, In : Scientific Reports. 8, 1, 17868.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Erratum: Author Correction: Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays (Scientific reports (2017) 7 1 (989))

Hao, W. R., Chen, M., Chen, Y. J., Su, Y. C., Cheng, C. M., Hsueh, H. Y., Kao, A. P., Hsieh, Y. C., Chang, J., Tseng, M. Y. & Chuang, K. H., Mar 6 2018, In : Scientific Reports. 8, 1, 1 p., 4256.

Research output: Contribution to journalComment/debate

Open Access

Genomic Alterations of Extrectra Cellular Genes as Diagnosis Markers for Head and Neck Squamous Cell Carcinoma

Yang, C-H., Lin, R-D., Lee, M-H., Tsai, M-H. & Su, L-J., 2018, In : International Journal of Head and Neck Science. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target

Hung, C. S., Wang, S. C., Yen, Y. T., Lee, T. H., Wen, W. C. & Lin, R. K., Oct 10 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibitory effects of punicalagin from Punica granatum against type II collagenase-induced osteoarthritis

Lee, C. J., Chen, L. G., Liang, W. L., Hsieh, M. S. & Wang, C. C., Feb 1 2018, In : Journal of Functional Foods. 41, p. 216-222 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)