Graduate Institute of Metabolism and Obesity Sciences

Research Output 2001 2020

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Disturbed Gastrointestinal Contractility in a Polycystic Ovary Syndrome Rat Model

Wang, K. L., Hsia, S. M., Wang, P. S. & Lin, P. H., Jan 1 2020, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Acetylcholine
Stomach
Colon
Carbachol

Fish oil up-regulates hepatic autophagy in rats with chronic ethanol consumption

Lu, N. S., Chiu, W. C., Chen, Y. L., Peng, H. C., Shirakawa, H. & Yang, S. C., Mar 2020, In : Journal of Nutritional Biochemistry. 77, 108314.

Research output: Contribution to journalArticle

Fish Oils
Autophagy
Rats
Ethanol
Up-Regulation
1 Citation (Scopus)

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, e12620.

Research output: Contribution to journalArticle

Leiomyoma
Melatonin
Cell Death
Cell Proliferation
Myometrium

Synbiotic combination of djulis (Chenopodium formosanum) and lactobacillus acidophilus inhibits colon carcinogenesis in rats

Lee, C. W., Chen, H. J., Chien, Y. H., Hsia, S. M., Chen, J. H. & Shih, C. K., Jan 2020, In : Nutrients. 12, 1, 103.

Research output: Contribution to journalArticle

Open Access
Chenopodium
Synbiotics
Lactobacillus acidophilus
carcinogenesis
colon
2019
Calcitriol
Granulosa Cells
Phosphatidylinositol 3-Kinases
Rats
Estradiol
2 Citations (Scopus)

6,7-dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

Chiu, C. F., Lai, G. Y., Chen, C. H., Chiu, C. C., Hung, S. W. & Chang, C. F., Jan 1 2019, In : Drug Design, Development and Therapy. 13, p. 1609-1621 13 p.

Research output: Contribution to journalArticle

Open Access
HCT116 Cells
Endoplasmic Reticulum Stress
Colorectal Neoplasms
Apoptosis
Cyclin B
Return to Work
Appointments and Schedules
Rehabilitation
ROC Curve
Traumatic Brain Injury
2 Citations (Scopus)
Return to Work
Head and Neck Neoplasms
Survivors
Appointments and Schedules
Taiwan

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases
2 Citations (Scopus)
Open Access
Coix
Stigmasterol
smooth muscle
hormones
Leiomyoma
1 Citation (Scopus)
Hip Fractures
Poliomyelitis
Cohort Studies
Population
International Classification of Diseases
4 Citations (Scopus)

A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus

Lee, H. C., Yu, S. C., Lo, Y. C., Lin, I. H., Tung, T. H. & Huang, S. Y., Feb 1 2019, In : Food and Function. 10, 2, p. 786-798 13 p.

Research output: Contribution to journalArticle

Dysbiosis
Linoleic Acid
diabetes mellitus
intestinal microorganisms
linoleic acid
1 Citation (Scopus)

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron
2 Citations (Scopus)

Antifatigue activity and exercise performance of phenolic-rich extracts from calendula officinalis, ribes nigrum, and vaccinium myrtillus

Tung, Y. T., Wu, M. F., Lee, M. C., Wu, J. H., Huang, C. C. & Huang, W. C., Jan 1 2019, In : Nutrients. 11, 8, 1715.

Research output: Contribution to journalArticle

Open Access
Calendula
Vaccinium myrtillus
Ribes
Calendula officinalis
Ribes nigrum
1 Citation (Scopus)

Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression

Tu, H. F., Chen, M. Y., Lai, J. C. Y., Chen, Y. L., Wong, Y. W., Yang, C. C., Chen, H. Y., Hsia, S. M., Shih, Y. H. & Shieh, T. M., Jan 1 2019, In : Head and Neck.

Research output: Contribution to journalArticle

Arecoline
Ataxia Telangiectasia
Mouth Neoplasms
Squamous Cell Carcinoma
DNA Repair
2 Citations (Scopus)

Assessing causality between childhood adiposity and early puberty: A bidirectional Mendelian randomization and longitudinal study

Chen, Y. C., Fan, H. Y., Yang, C., Hsieh, R. H., Pan, W. H. & Lee, Y. L., Nov 1 2019, In : Metabolism: Clinical and Experimental. 100, 153961.

Research output: Contribution to journalArticle

Adiposity
Puberty
Random Allocation
Causality
Longitudinal Studies
1 Citation (Scopus)
Open Access
Dementia
Aptitude
Appointments and Schedules
Internship and Residency
Activities of Daily Living
Taiwan
Nitric Oxide
Obesity
Psychology
Linear Models

Autoimmune Connective Tissue Diseases and the Risk of Rotator Cuff Repair Surgery: A Population-Based Retrospective Cohort Study

Huang, S. W., Lin, C. L., Lin, L. F., Huang, C. C., Liou, T. H. & Lin, H. W., Feb 25 2019, In : BMJ Open. 9, 2, e023848.

Research output: Contribution to journalArticle

Open Access
Connective Tissue Diseases
Rotator Cuff
Cohort Studies
Retrospective Studies
Population

Body mass index growth trajectories, early pubertal maturation, and short stature

Fan, H. Y., Lee, Y. L., Hsieh, R. H., Yang, C. & Chen, Y. C., Jan 1 2019, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

Body Mass Index
Puberty
Growth
Sleep
Fats
10 Citations (Scopus)

Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis

Chen, Y. C., Fan, H. Y., Huang, Y. T., Huang, S. Y., Liou, T. H. & Lee, Y. L., Jan 1 2019, In : International Journal of Obesity. 43, 1, p. 73-81

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Adiposity
Asthma
Body Mass Index
Single Nucleotide Polymorphism

Clinical association between the metabolite of healthy gut microbiota, 3-indolepropionic acid and chronic kidney disease

Sun, C. Y., Lin, C. J., Pan, H. C., Lee, C. C., Lu, S. C., Hsieh, Y. T., Huang, S. Y. & Huang, H. Y., 2019, In : Clinical Nutrition.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Indican
Kidney
Healthy Volunteers
Metabolome
9 Citations (Scopus)
Open Access
Lactobacillus acidophilus
HT29 Cells
Probiotics
anti-inflammatory activity
probiotics

Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice

Lee, H-C., Lo, Y-C., Yu, S-C., Tung, T-H., Lin, I-H. & Huang, S-Y., Oct 23 2019, In : International Journal of Food Sciences and Nutrition. p. 1-13 13 p.

Research output: Contribution to journalArticle

intestinal microorganisms
Lipids
mice
lipids
Prefrontal Cortex
1 Citation (Scopus)
Open Access
Parkinson Disease
Dementia
Appointments and Schedules
Activities of Daily Living
Disability Evaluation
1 Citation (Scopus)

Determinants of Employment Outcome for the People with Schizophrenia Using the WHODAS 2.0

Lu, S. J., Liou, T. H., Yen, C. F., Chang, F. H., Chen, Y. L., Escorpizo, R., Strauser, D. R. & Pan, A. W., 2019, In : Journal of Occupational Rehabilitation. p. 1-9 9 p.

Research output: Contribution to journalArticle

Schizophrenia
ROC Curve
Demography
Disability Evaluation
Taiwan

Dietary antioxidant trans-cinnamaldehyde reduced visfatin-induced breast cancer progression: In vivo and in vitro study

Chiang, Y. F., Chen, H. Y., Huang, K. C., Lin, P. H. & Hsia, S. M., Dec 2019, In : Antioxidants. 8, 12, 625.

Research output: Contribution to journalArticle

Open Access
Nicotinamide Phosphoribosyltransferase
Antioxidants
Breast Neoplasms
Neoplasms
Cells
1 Citation (Scopus)

Dietary glycotoxins, advanced glycation end products, inhibit cell proliferation and progesterone secretion in ovarian granulosa cells and mimic PCOS-like symptoms

Lin, P. H., Chang, C. C., Wu, K. H., Shih, C. K., Chiang, W., Chen, H. Y., Shih, Y. H., Wang, K. L., Hong, Y. H., Shieh, T. M. & Hsia, S. M., Aug 1 2019, In : Biomolecules. 9, 8, 327.

Research output: Contribution to journalArticle

Open Access
Advanced Glycosylation End Products
Granulosa Cells
Polycystic Ovary Syndrome
Cell proliferation
Progesterone

Dietary Profiles, Nutritional Biochemistry Status, and Attention-Deficit/Hyperactivity Disorder: Path Analysis for a Case-Control Study

Wang, L-J., Yu, Y-H., Fu, M-L., Yeh, W-T., Hsu, J-L., Yang, Y-H., Yang, H-T., Huang, S-Y., Wei, I-L., Chen, W. J., Chiang, B-L. & Pan, W-H., May 18 2019, In : Journal of Clinical Medicine. 8, 5, p. 709

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Nutritional Status
Biochemistry
Case-Control Studies
Food
2 Citations (Scopus)
Lycopersicon esculentum
Dietary Supplements
Sleep
Melatonin
Eating

Discovery of a role of the novel hepatokine, hepassocin, in obesity

Huang, R. L., Li, C. H., Du, Y. F., Cheng, K. P., Lin, C. H., Hu, C. Y., Wu, J. S., Chang, C. J., Wu, H. T. & Ou, H. Y., Jan 1 2019, (Accepted/In press) In : BioFactors.

Research output: Contribution to journalArticle

Obesity
Insulin
Blood pressure
Biomarkers
Public health

Dysregulated iron metabolism-associated dietary pattern predicts an altered body composition and metabolic syndrome

Cempaka, A. R., Tseng, S. H., Yuan, K. C., Bai, C. H., Tinkov, A. A., Skalny, A. V. & Chang, J. S., Nov 2019, In : Nutrients. 11, 11, 2733.

Research output: Contribution to journalArticle

Open Access
metabolic syndrome
Body Composition
eating habits
body composition
Iron
3 Citations (Scopus)
Upper Extremity
Lower Extremity
Education
Cytidine Triphosphate
Information Storage and Retrieval
1 Citation (Scopus)
Electric Stimulation Therapy
Electric Stimulation
Meta-Analysis
Arm
Randomized Controlled Trials
Caloric Restriction
Blood Proteins
Proteins
Complement C4b-Binding Protein
alpha-Macroglobulins

Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes

Lin, A-C., Hung, H-C., Chen, Y-W., Cheng, K-P., Li, C-H., Lin, C-H., Chang, C-J., Wu, H-T. & Ou, H-Y., Oct 6 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

Hedgehog Proteins
Prediabetic State
Type 2 Diabetes Mellitus
Glucose
Fasting

Evaluation of a technological image-based dietary assessment tool for children during pubertal growth: A pilot study

Wang, J. S., Hsieh, R. H., Tung, Y. T., Chen, Y. C., Chen, Y. H. & Yang, C., Oct 20 2019, In : Nutrients. 11, 10, 2527.

Research output: Contribution to journalArticle

Open Access
Micronutrients
dietary minerals
Growth
Nutritionists
food records
1 Citation (Scopus)

Fish Oil, but Not Olive Oil, Ameliorates Depressive-Like Behavior and Gut Microbiota Dysbiosis in Rats under Chronic Mild Stress

Tung, T. H., Tung, Y. T., Lin, I. H., Shih, C. K., Nguyen, N. T. K., Shabrina, A. & Huang, S. Y., Sep 21 2019, In : Biomolecules. 9, 10

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Fish Oils
Rats
Sucrose
Diet
Reducing Diet
Haptoglobins
Phenotype
Waist Circumference
Abdominal Obesity
2 Citations (Scopus)

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation
1 Citation (Scopus)

Isoliquiritigenin suppresses E2-induced uterine leiomyoma growth through the modulation of cell death program and the repression of ECM accumulation

Lin, P. H., Kung, H. L., Chen, H. Y., Huang, K. C. & Hsia, S. M., Aug 1 2019, In : Cancers. 11, 8, 1131.

Research output: Contribution to journalArticle

Open Access
Leiomyoma
Extracellular Matrix
Cell Death
Myometrium
Growth
Open Access
Lactobacillus acidophilus
brown rice
colon
Colon
Aberrant Crypt Foci

Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

Chen, L. H., Huang, S. Y., Huang, K. C., Hsu, C. C., Yang, K. C., Li, L. A., Chan, C. H. & Huang, H. Y., Jan 1 2019, In : Aging. 11, 2, p. 756-770 15 p.

Research output: Contribution to journalArticle

Sarcopenia
Muscles
Reactive Oxygen Species
Muscle Strength
Control Groups

Marketing strategy, serving size, and nutrition information of popular children’s food packages in Taiwan

Chen, M. C., Chien, Y. W., Yang, H. T. & Chen, Y. C., Jan 15 2019, In : Nutrients. 11, 1, 174.

Research output: Contribution to journalArticle

Open Access
Serving Size
serving size
marketing strategies
nutrition information
Marketing
3 Citations (Scopus)

Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety

Kumaran Satyanarayanan, S., Chien, Y-C., Pei-Chen Chang, J., Huang, S-Y., Guu, T-W., Su, H. & Su, K-P., Mar 6 2019, In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Circadian Clocks
Neuronal Plasticity
Anxiety
Depression
Genes
2 Citations (Scopus)

Melatonin improves fatty liver syndrome by inhibiting the lipogenesis pathway in hamsters with high-fat diet-induced hyperlipidemia

Ou, T. H., Tung, Y. T., Yang, T. H. & Chien, Y. W., Mar 30 2019, In : Nutrients. 11, 4, p. 748 748.

Research output: Contribution to journalArticle

Open Access
Lipogenesis
fatty liver
lipogenesis
High Fat Diet
melatonin

Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells

Ho, S-T., Lin, C-C., Tung, Y-T. & Wu, J-H., Sep 17 2019, In : Cancers. 11, 9

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Microtubules
Growth
Cell Cycle
Cupressaceae
4 Citations (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 12 2019, In : Antioxidants. 8, 4

Research output: Contribution to journalArticle

Leiomyoma
Cell growth
Extracellular Matrix
Antioxidants
Growth