Graduate Institute of Clinical Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1988 2020

2020

A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma–TCOG T1211 study

Chiang, N. J., Tsai, K. K., Hsiao, C. F., Yang, S. H., Hsiao, H. H., Shen, W. C., Hsu, C., Lin, Y. L., Chen, J. S., Shan, Y. S. & Chen, L. T., Jan 2020, In : European Journal of Cancer. 124, p. 123-130 8 p.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Leucovorin
Adenocarcinoma
irinotecan

Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme

Lee, H. H., Lin, C. H., Lin, H. Y., Kuei, C. H., Zheng, J. Q., Wang, Y. H., Lu, L. S., Lee, F. P., Hu, C. J., Wu, D. & Lin, Y. F., Jan 2020, In : Cancers. 12, 1, 98.

Research output: Contribution to journalArticle

Open Access
temozolomide
Glioblastoma
Histones
Interleukin-6
Up-Regulation

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., Jan 2020, In : Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

Open Access
Uncaria
neuroprotective effect
Inhibitory Concentration 50
inhibitory concentration 50
Oxidopamine

Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury: A systematic review and meta-analysis

Chen, C. T., Chang, L. Y., Chuang, C. W., Wang, S. C., Kao, M. C., Tzeng, I. S., Kuo, K. L., Wu, C. C., Tsai, P. S. & Huang, C. J., Jan 2020, In : Toxicology Letters. 318, p. 65-73 9 p.

Research output: Contribution to journalArticle

Cystatin C
Acute Kidney Injury
Meta-Analysis
Contrast Media
Peripheral Catheterization

Relationship Between Diurnal Cortisol Profile and Sleep Quality in Patients With Hepatocellular Carcinoma

Huang, T. W., Cheung, D. S. T., Xu, X., Loh, E. W., Lai, J. H., Su, W. W., Wu, S. S. & Lin, C. C., Jan 1 2020, In : Biological Research for Nursing. 22, 1, p. 139-147 9 p.

Research output: Contribution to journalArticle

Hydrocortisone
Hepatocellular Carcinoma
Sleep
Circadian Rhythm
Saliva
2019

A bioinspired hyperthermic macrophage-based polypyrrole-polyethylenimine (Ppy-PEI) nanocomplex carrier to prevent and disrupt thrombotic fibrin clots

Burnouf, T., Chen, C. H., Tan, S. J., Tseng, C. L., Lu, K. Y., Chang, L. H., Nyambat, B., Huang, S. C., Jheng, P. R., Aditya, R. N., Mi, F. L. & Chuang, E. Y., Sep 15 2019, In : Acta Biomaterialia. 96, p. 468-479 12 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Macrophages
Polypyrroles
Fibrin
Radiation
3 Citations (Scopus)

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

Jan, Y. H., Lai, T. C., Yang, C. J., Lin, Y. F., Huang, M. S. & Hsiao, M., Jan 29 2019, In : Journal of Hematology and Oncology. 12, 1, 12.

Research output: Contribution to journalArticle

Adenylate Kinase
Oxidative Stress
Neoplasm Metastasis
Lung Neoplasms
Epithelial-Mesenchymal Transition
Mitochondrial DNA
Embryonic Structures
Biomarkers
Blastocyst
Blastomeres

Adverse stroke outcomes among patients with bipolar disorder

Chen, P. H., Kao, Y. W., Shia, B. C., Lin, H. C. & Kang, J. H., Mar 1 2019, In : PLoS One. 14, 3, p. e0213072 e0213072.

Research output: Contribution to journalArticle

Open Access
Bipolar Disorder
stroke
Stroke
Length of Stay
Hospital Mortality
1 Citation (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., Nov 1 2019, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Radiation Tolerance
Autophagy
Proteins

Angiotensin-converting enzyme inhibitors or angiotensin receptor blocker monotherapy retard deterioration of renal function in Taiwanese chronic kidney disease population

Zheng, C. M., Wang, J. Y., Chen, T. T., Wu, Y. C., Wu, Y. L., Lin, H. T., Chiu, S. P., Chang, T. J., Zheng, J. Q., Chu, N. F., Lin, Y. M., Su, S. L., Lu, K. C., Chen, J. S., Sung, F. C., Lee, C. T., Yang, Y., Hwang, S. J., Wang, M. C., Hsu, Y. H. & 4 others, Chiou, H. Y., Kao, S., Wu, M. Y. & Lin, Y. F., Dec 1 2019, In : Scientific Reports. 9, 1, 2694.

Research output: Contribution to journalArticle

Open Access
Angiotensin Receptor Antagonists
Chronic Renal Insufficiency
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Kidney
4 Citations (Scopus)

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma

El Dika, I., Lim, H. Y., Yong, W. P., Lin, C. C., Yoon, J. H., Modiano, M., Freilich, B., Choi, H. J., Chao, T. Y., Kelley, R. K., Brown, J., Knox, J., Ryoo, B. Y., Yau, T. & Abou-Alfa, G. K., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Maximum Tolerated Dose
Hepatocellular Carcinoma
Pharmacokinetics
Safety
Small Interfering RNA
Castration
Autophagy
Prostatic Neoplasms
Cell Death
Osteogenesis
Povidone-Iodine
Local Anti-Infective Agents
Chlorhexidine
Meta-Analysis
Randomized Controlled Trials
1 Citation (Scopus)

Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Chen, J. H., T.H Wu, A., T.W Tzeng, D., Huang, C. C., Tzeng, Y. M. & Chao, T. Y., Jan 1 2019, In : Phytomedicine. 52, p. 70-78 9 p.

Research output: Contribution to journalArticle

Antrodia
Catenins
Carcinogenesis
Breast
Down-Regulation
6 Citations (Scopus)

ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., Feb 21 2019, In : Oncogene. 38, 8, p. 1340-1353 14 p.

Research output: Contribution to journalArticle

Catenins
Microcephaly
Prostatic Neoplasms
Neoplastic Stem Cells
Neoplasms
Open Access
Acid Sensing Ion Channels
Brain Concussion
Dizziness
Alleles
Genes
1 Citation (Scopus)

Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients

Wu, Y. L., Chien, M. H., Chou, Y. E., Chang, J. H., Liu, T. C., Tsao, T. C. Y., Chou, M. C. & Yang, S. F., Jan 1 2019, In : Journal of Cancer. 10, 13, p. 2907-2914 8 p.

Research output: Contribution to journalArticle

Open Access
HMGB1 Protein
Genetic Polymorphisms
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Kao, C. C., Cheng, S. Y., Wang, Y. J., Chien, S. C., Hsu, Y. W., Wu, M. Y., Lu, H. F., Nam, S., Sun, T., Wu, M. S. & Chang, W. C., Jun 5 2019, In : BMC Nephrology. 20, 1, p. 203 203.

Research output: Contribution to journalArticle

Open Access
Endothelins
Chronic Kidney Failure
Bacteremia
Infection
Single Nucleotide Polymorphism
1 Citation (Scopus)
Hashimoto Disease
Osteopontin
Lymphocytes
Graves Disease
Thyroid Diseases
1 Citation (Scopus)
Renal Dialysis
Meta-Analysis
Catheters
Confidence Intervals
Incidence
1 Citation (Scopus)
Open Access
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
4 Citations (Scopus)

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

Chang, T. C., Wei, P. L., Makondi, P. T., Chen, W. T., Huang, C. Y. & Chang, Y. J., Jan 1 2019, In : PLoS One. 14, 1, e0210274.

Research output: Contribution to journalArticle

bromelains
Bromelains
autophagy
Autophagy
colorectal neoplasms
Triple Negative Breast Neoplasms
Catenins
Neoplastic Stem Cells
Down-Regulation
Phenotype

Chemotherapy agents induce tartrate-resistant acid phosphatase 5a contributing to the symptom distress in lung cancer patients

Chou, H. L., Chao, T. Y., Chen, T. C., Chu, C. M., Hsieh, C. H., Lin, L. I. & Yao, C. T., Mar 5 2019, In : European Journal of Pharmacology. p. 38-48 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Drug Therapy
Monocytes
Macrophages
gemcitabine
1 Citation (Scopus)

Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia

Hsu, S. C., Chang, J. H., Hsu, Y. P., Bai, K. J., Huang, S. K. & Hsu, C. W., May 1 2019, In : PLoS ONE. 14, 5, e0216963.

Research output: Contribution to journalArticle

Open Access
sphingosine
Biomarkers
pneumonia
biomarkers
Pneumonia
1 Citation (Scopus)

Cluster of differentiation 14 and toll-like receptor 4 are involved in the anti-inflammatory effects of tyrosol

Chang, C. Y., Huang, I. T., Shih, H. J., Chang, Y. Y., Kao, M. C., Shih, P. C. & Huang, C. J., Feb 1 2019, In : Journal of Functional Foods. 53, p. 93-104 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
anti-inflammatory activity
lipopolysaccharides
Lipopolysaccharides
Anti-Inflammatory Agents

Comparing short-, long-, and oblique-axis approaches to ultrasound-guided internal jugular venous catheterization: A meta-analysis of randomized controlled trials

Chen, J. Y., Wang, L. K., Lin, Y. T., Lan, K. M., Loh, E. W., Chen, C. H. & Tam, K. W., Mar 1 2019, In : Journal of Trauma and Acute Care Surgery. 86, 3, p. 516-523 8 p.

Research output: Contribution to journalReview article

Punctures
Catheterization
Hematoma
Needles
Meta-Analysis

Correction: Hou et al. Emerging role of vitamins D and K in modulating uremic vascular calcification: The aspect of passive calcification. (Nutrients (2019), 11(1), 152, 10.3390/nu11010152)

Hou, Y. C., Lu, C. L., Zheng, C. M., Chen, R. M., Lin, Y. F., Liu, W. C., Yen, T. H., Chen, R. & Lu, K. C., Mar 1 2019, In : Nutrients. 11, 3, 567.

Research output: Contribution to journalComment/debate

Open Access
vitamin K deficiency
Vitamin K Deficiency
Vascular Calcification
vitamin K
Vitamin K
3 Citations (Scopus)

Correction: ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling (Oncogene, (2019), 38, 8, (1340-1353), 10.1038/s41388-018-0497-4)

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., Feb 21 2019, In : Oncogene. 38, 8, p. 1354 1 p.

Research output: Contribution to journalComment/debate

Catenins
Oncogenes
Prostatic Neoplasms
Open Access
Chemokine CCL2
Endothelial cells
Intercellular Adhesion Molecule-1
Interleukin-8
Endothelial Cells
Inflammasomes
Taiwan
Calcium
Anesthesiology
Research
Emotions
Wounds and Injuries
corrigendum
1 Citation (Scopus)
Internal Medicine
Malondialdehyde
Taiwan
Autoantibodies
Proteomics

Deep Intronic Variant c.5999-277G>A of F8 Gene May Be a Hot-Spot Mutation for Mild Hemophilia A Patients Without Mutation in Exonic DNA

Chang, C-Y., Perng, C-L., Cheng, S-N., Hu, S-H., Wu, T-Y., Lin, S-Y. & Chen, Y-C., May 7 2019, In : European Journal of Haematology.

Research output: Contribution to journalArticle

Hemophilia A
Mutation
DNA
Exons
Genes

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 5 2019, In : Journal of Biomedical Science. 26, 1, 96.

Research output: Contribution to journalReview article

Open Access
Programmed Cell Death 1 Receptor
CTLA-4 Antigen
Chemotherapy
Radiotherapy
Biomarkers
2 Citations (Scopus)
Bioinformatics
Computational Biology
colorectal neoplasms
MicroRNAs
microRNA

Diabetic retinopathy as a risk factor for chronic kidney disease progression: A multicenter case–control study in Taiwan

Lin, H. T., Zheng, C. M., Wu, Y. C., Chang, Y. H., Chen, J. T., Liang, C. M., Chang, T. J., Zheng, J. Q., Tai, M. C. & Lin, Y. F., Mar 1 2019, In : Nutrients. 11, 3, 509.

Research output: Contribution to journalArticle

Open Access
diabetic retinopathy
Diabetic Retinopathy
kidney diseases
Taiwan
Chronic Renal Insufficiency

Differences between COPD patients and their families regarding willingness toward life-sustaining treatments

Chen, T. R., Hu, W. Y., Chiu, T. Y. & Kuo, H. P., Jan 2019, (Accepted/In press) In : Journal of the Formosan Medical Association. 118, 1P3, p. 414-419

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Therapeutics
Medical Futility
Persistent Vegetative State
Noninvasive Ventilation
3 Citations (Scopus)

DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint

Lee, W-H., Chen, L-C., Lee, C-J., Huang, C-C., Ho, Y-S., Yang, P-S., Ho, C-T., Chang, H-L., Lin, I-H., Chang, H-W., Liu, Y-R., Wu, C-H. & Tu, S-H., Feb 1 2019, In : International Journal of Cancer. 144, 3, p. 615-630 16 p.

Research output: Contribution to journalArticle

DNA Primase
G2 Phase Cell Cycle Checkpoints
Estrogens
Breast Neoplasms
Peptides

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
Hypoglycemic Agents
pioglitazone
Neoplasms
Odds Ratio
Confidence Intervals

Dysregulated iron metabolism-associated dietary pattern predicts an altered body composition and metabolic syndrome

Cempaka, A. R., Tseng, S. H., Yuan, K. C., Bai, C. H., Tinkov, A. A., Skalny, A. V. & Chang, J. S., Nov 2019, In : Nutrients. 11, 11, 2733.

Research output: Contribution to journalArticle

Open Access
metabolic syndrome
Body Composition
eating habits
body composition
Iron

Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Lau, C. I., Liu, M. N., Chang, K. C., Chang, A., Bai, C. H., Tseng, C. S., Walsh, V. & Wang, H. C., Jan 1 2019, (Accepted/In press) In : CNS Neuroscience and Therapeutics.

Research output: Contribution to journalArticle

Open Access
Cognition
Parkinson Disease
Prefrontal Cortex
Short-Term Memory
Disruptive, Impulse Control, and Conduct Disorders