Graduate Institute of Clinical Medicine

Projects

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• 20 Active
• 378 Finished

Projects per year

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• Finished

  攜帶Rrm2b質體的奈米載體系統用於治療慢性腎臟疾病的潛力研究

  Chiu, H.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Sirtuin 1 對小鼠心律不整及心房顫動之影響及鈣離子與電生理之調控

  Kao, Y.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 乳房影像報告人工智慧醫療助理第一期發展計畫

  Loh, E.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 降血壓藥物(angiotensin-converting enzyme inhibitor, ACEI)對降低缺血性中風患者的神經性退化性疾病及其死亡率之療效評估：以帕金森氏症及失智症為例

  Chen, T.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 數位化乳房攝影鈣化特異性之人工智能深度學習及分析

  Chan, W. P.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 城市角落苗圃：設計思考化跨域教與學

  Chu, J.

  12/1/20 → 5/31/21

  Project: A - Government Institution › d - Ministry of Education

• 攜帶Rrm2b質體的奈米載體系統用於治療慢性腎臟疾病的潛力研究

  Chiu, H.

  10/1/20 → 12/31/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 探討Sirtuin 1 訊息路徑作為心房顫動致病機轉及新治療策略

  Kao, Y.

  10/1/20 → 12/31/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 探討腎臟細胞暴露於塑膠微粒和塑膠奈米中誘發自體吞噬作用和增加SREBPs並引起血管內皮細胞滲漏作用之機制(1/3)

  Chiu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討KH-Type切割調控蛋白在腎細胞癌惡性進程中所扮演的角色(1/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用人工智慧虛擬篩選平台鑑定DNA聚合?theta之小分子抑制劑和評估其對於轉移型去勢抗性之攝護腺癌的治療效果(2/3)

  Lin, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-節拍式化學治療增進基質硬化性胰臟癌免疫監督與免疫檢查點阻斷療法: 聚焦於腫瘤基質與髓源性抑制細胞(2/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(1/3)

  Lin, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討 CWH43 大腸直腸癌發展的角色及其調控機制

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討在慢性腎臟疾病中經由抑制內皮素轉化酶調節前列腺素E2受體和自體吞噬作用的治療潛力之機轉(1/3)

  Lin, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 調控半乳糖凝集素之免疫訊號重整作用對心房再塑與心律不整活性的病理機轉探討：一個新的治療心房顫動契機(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ZFHX3 knockdown調控心房纖維化導致心房顫動病理性結構重塑之機轉探討

  Kao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 電漿活化水對潰瘍性大腸炎及克隆氏症等腸道炎症微生物菌叢的影響-由藥物誘導鼠及基因轉殖鼠探討(2/2)

  Chang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bicalutamide經Sirt3/p53引發腎膈細胞電子傳遞鏈複合體I缺陷而致細胞凋亡機制的探討-輔以Idebenone及MitoTempo提升氧化磷酸化系統及調節粒線體動態之治療策略評估

  Peng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(2/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對IL-33/ST2訊息路徑調控鈣平衡、內質網壓力與粒線體功能作為心房與肺靜脈心律不整活性與心房顫動致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討第一型內皮細胞分子與上皮細胞生長因子受體之相互調控在非小細胞肺癌進程之角色(3/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 絲氨酸/蘇氨酸蛋白激酶(SIK3)參與乳癌致癌過程的分子機制探討

  Chen, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎癌幹細胞侵犯腳治療標靶之整合性蛋白質體、基因體、小分子與功 能篩選：聚焦細胞表面AMFR於侵犯性消化道癌症治療標的(1/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 纖維細胞生長因子與其受體之訊息路徑在急性腎損傷中維持腎臟血管結構能力之角色研究

  Cheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• anti-EGFR×anti-FAP雙辨識特異性抗體結合包覆抗癌藥物Irinotecan標靶微脂體治療胰臟癌之研究(3/3)

  Lin, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色: 調控T細胞的效應及逆轉賀癌平抗藥性的分子機制(2/3)

  Chao, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫三：運用跨模態多項次神經影像技術探討神經調控模式對脊髓損傷者之神經可塑性與功能變化(2/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展以同步量測中樞與周邊系統功能性訊息為導向之年長跌倒患者步態復健評估(3/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用多模式小動物進階磁振造影技術定量膠質母細胞瘤之研究(2/2)

  Liu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 間質幹細胞之外泌體於減緩肥胖及肥胖併發敗血症於小鼠所致心臟病變之療效與其調控氧化、發炎、粒線體異常及胰島素抵抗之效應探討(3/3)

  Huang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以anti-FAP/anti-CD3雙功能抗體武裝之毒殺型T細胞搭配臨床化療藥物治療腫瘤纖維化之胰臟癌

  Lin, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討內皮素誘發NLRP3發炎體於慢性腎臟疾病之角色

  Chiu, H.

  5/1/20 → 4/30/21

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討經PGC1-α調控粒線體動態參與Bicalutamide所引致的細胞凋亡

  Peng, C.

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 改善於電性重塑引發氧化壓力及細胞內鈣離子調控異常作為心房纖維顫動治療策略的研究

  Kao, Y.

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 探討第一型內皮細胞分子胃癌進程之角色及相關調控機制

  Chien, M.

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › n - Yuan's General Hospital

• 探討SH2 Domain Containing 5 (SH2D5)促進大腸癌細胞進程之分子機轉

  Lin, Y.

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › n - Yuan's General Hospital

• ASPM與Wnt訊息傳導在肝癌幹原性與惡化以及相關奈米基因治療之開發

  Tsai, K. K.

  1/1/20 → 12/31/20

  Project: A - Government Institution › a - National Health Research Institutes

• 數位化乳房攝影鈣化特異性之人工智能深度學習及分析

  Chan, W. P.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 乳房影像報告人工智慧醫療助理第一期發展計畫

  Loh, E.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 降血壓藥物(angiotensin-converting enzyme inhibitor, ACEI)對降低缺血性中風患者的神經性退化性疾病及其死亡率之療效評估：以帕金森氏症及失智症為例

  Chen, T.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 2-1-3 精進核心研究服務平台-胃腸道腫瘤精準醫療奈米與免疫指標暨療法開發

  Tsai, K. K.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色：調控T細胞的效應及逆轉賀癌平抗藥性的分子機制

  Chao, T.

  1/1/20 → 12/31/20

  Project: A - Government Institution › a - National Health Research Institutes

• 新聘教師研究補助

  Shen, Y.

  9/1/19 → 8/31/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Metronomic Chemotherapy Potentiates Immuno-Surveillance and Immunotherapy in Desmoplastic Pancreatic Cancer: Focusing on the Roles of Tumor Stroma and Myeloid-Derived Suppressor Cells( I )(1/3)

  Tsai, K. K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing Artificial Intelligence Vi Rtual Screening Platform to Identify a Small-Molecule Inhibitor of Dna Polymerase Theta and Estimating Its Therapeutic Effectiveness on Metastatic Castration-Resistant Prostate Cancer

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Endoplasmic Reticulum Stress Response and Autophagy in Chronic Kidney Disease by Nanoparticle Drug Delivery System

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Aspm-Par-Pcp Signaling in Invasive-Cancer-Stem-Cell-Mediated Metastasis and Its Therapeutic Targeting(1/3)

  Tsai, K. K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Simultaneous Center-Periphery Neuroimaging for Data-Driven Rehabilitation Assessment of Fallers(2/3)

  Chan, W. P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Role of Btk/Her2 Signaling as a Therapeutic Target for Restoration of T Cell Function and Reversal of Trastuzumab Resistance in Her2+ Breast Cancer(1/3)

  Chao, T.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology