Graduate Institute of Clinical Medicine

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2023

• 11 Active
• 403 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anesthesia 100%
  • Postoperative Complications 87%
  • Databases 61%
  • National Health Programs 53%
  • Taiwan 50%

• Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation

  Chan, W. P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Perfusion 100%
  • Bone Marrow 87%
  • Fats 39%
  • Osteoporosis 35%
  • Neoplasm Metastasis 32%

• Mechanistic Exploration of the Role of SCUBE2 in Suppressing the Generation of Cancer Stem Cells and Its Potential in Developing Novel Therapeutics (III)

  Chao, T.

  5/1/14 → 4/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Systemic Analysis on Dynamic Mechanism of Actin Cytoskeleton Organization Regulated Physiological Changes Caused by Physical Stimuli in Mesenchymal Stem Cells

  Ho, J. & Chang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Actins 100%
  • Mesenchymal Stem Cells 72%
  • Proteins 24%
  • Polymerization 22%
  • Microfilament Proteins 19%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Catenins 31%

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

  Lee, Y., Leu, S. & Liu, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dendritic Cells 100%
  • Ligands 43%
  • Asthma 39%
  • STAT4 Transcription Factor 34%
  • Th2 Cells 23%

• Simultaneous Center-Periphery Neuroimaging for Data-Driven Rehabilitation Assessment of Fallers

  Chan, W. P.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 纖維細胞生長因子與其受體之訊息路徑在急性腎損傷中維持腎臟血管結構能力之角色研究

  Cheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reconstitution of Spermatogenesis from Testis Failure after Spermatogonial Stem Cells (Ssc) Transplantation for Male Fertility Preservation-A Transgenic Mouse Model

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stem cells 100%
  • stems 51%
  • cryopreservation 37%
  • germ cells 26%
  • mice 21%

• Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

  Tsai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Osteoclasts 100%
  • Arthritis 34%
  • Osteogenesis 33%
  • Lipids 31%
  • Inflammation 28%

• Wnt/Tenascin Regulates Neurotrophin-Induced Neuronal Transdifferentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in 2d and 3d Cultures

  Lai, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mesenchymal Stem Cells 100%
  • Tenascin 82%
  • Stem Cells 63%
  • Nerve Growth Factors 40%
  • Neurons 30%

• 大部耳膜缺損之預防與修復

  Lai, W.

  8/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以anti-FAP/anti-CD3雙功能抗體武裝之毒殺型T細胞搭配臨床化療藥物治療腫瘤纖維化之胰臟癌

  Lin, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Targeting for Potential Tumor Suppressor Genes, Poldip2 and Sox1, with Investigations of Prognostic and Therapeutic Implications in Non-Small Cell Lung Cancer

  Tzao, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heat-Shock Proteins 100%
  • Esophageal Squamous Cell Carcinoma 56%
  • Neoplasms 33%
  • 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 28%
  • Esophageal Neoplasms 24%

• Taipei Medical University Specialty Equipment Service Plan

  Lin, S.

  12/1/16 → 12/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nuclear magnetic resonance 100%
  • Reservation systems 86%
  • Magnetic resonance spectrometers 52%
  • Mass spectrometers 39%
  • Online systems 33%

• Drug Delivery by Nano Scaffold Improved Immature Testicular Tissue Graft Survival Rate -A Transgenic Mouse Model

  Chen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

  Tsai, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reconstitution of Spermatogenesis from Testis Failure after Spermatogonial Stem Cells (Ssc) Transplantation for Male Fertility Preservation-A Transgenic Mouse Model

  Chen, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stem cells 100%
  • stems 51%
  • cryopreservation 37%
  • germ cells 26%
  • mice 21%

• Regulation of Flip Expression and Apoptosis Signaling by Helicobacter Pylori

  Tsai, H.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • CASP8 and FADD-Like Apoptosis Regulating Protein 100%
  • Helicobacter pylori 86%
  • Apoptosis 25%
  • Stomach 15%
  • Epithelial Cells 15%

• Epigenetic Targeting for Potential Tumor Suppressor Genes, Poldip2 and Sox1, with Investigations of Prognostic and Therapeutic Implications in Non-Small Cell Lung Cancer

  Tzao, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy(2/3)

  Lin, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression: an Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs

  Wang, L.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Metastasis 100%
  • Genetic Promoter Regions 93%
  • Methylation 87%
  • Esophageal Neoplasms 66%
  • Tumor Suppressor Genes 63%

• Investigation of the transcriptional and epigenetic mechanisms for the Nm23-H1 expression: An nm23-H1-promoter screening platform for novel metastasis-suppressing anticancer drugs

  Wang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Metastasis 100%
  • Genetic Promoter Regions 93%
  • Methylation 87%
  • Esophageal Neoplasms 66%
  • Tumor Suppressor Genes 63%

• Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis

  Huang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以胜肽為基礎之細胞激素結合誘餌療法於治療敗血症之療效及其調控發炎、氧化、凋亡、自嗜與發炎小體之作用探討(1/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms with Epigenetic Regulation by Histone Deacetylation on Postopratetive Atrial and Pulmonary Vein Arrhythmogenesis

  Chen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylases 100%
  • Atrial Fibrillation 85%
  • Pulmonary Veins 63%
  • Calcium 44%
  • Heart Atria 40%

• 調控半乳糖凝集素之免疫訊號重整作用對心房再塑與心律不整活性的病理機轉探討：一個新的治療心房顫動契機(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

  Ho, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mesenchymal Stem Cells 100%
  • Mesenchymal Stem Cell Transplantation 21%
  • Aptitude 21%
  • Animal Disease Models 20%
  • Therapeutic Uses 13%

• Establishment of a Biophysical Effect-Based Platform for Rapid Expansion of Functional Mesenchymal Stem Cells

  Ho, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stromal cells 100%
  • stem cells 79%
  • cell transplantation 46%
  • microfluidic technology 39%
  • shear stress 32%

• Establishment of a Biophysical Effect-Based Platform for Rapid Expansion of Functional Mesenchymal Stem Cells

  Ho, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stromal cells 100%
  • stem cells 79%
  • cell transplantation 46%
  • microfluidic technology 39%
  • shear stress 32%

• 間質幹細胞之外泌體於減緩肥胖及肥胖併發敗血症於小鼠所致心臟病變之療效與其調控氧化、發炎、粒線體異常及胰島素抵抗之效應探討(3/3)

  Huang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms with Epigenetic Regulation by Histone Deacetylation on Postopratetive Atrial and Pulmonary Vein Arrhythmogenesis

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylases 100%
  • Atrial Fibrillation 85%
  • Pulmonary Veins 63%
  • Calcium 44%
  • Heart Atria 40%

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atrial Fibrillation 100%
  • MicroRNAs 68%
  • Calcium 48%
  • Electrophysiology 45%
  • Small Interfering RNA 34%

• Investigation of Endoplasmic Reticulum Stress Response and Autophagy in Chronic Kidney Disease by Nanoparticle Drug Delivery System

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M., Chen, Y. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• Epigenetic Role of Pitx2c in Atrial Myocyte and Fibroblast: Therapeutic Implications of Atrial Fibrillation Mechanisms

  Kao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibroblasts 100%
  • Calcium 50%
  • Histone Deacetylases 42%
  • MicroRNAs 41%
  • Electrophysiology 41%

• 自體免疫心肌炎引起心室心律不整及鈣離子調控失衡、粒線體異常與NLRP3/MIF發炎體訊息路徑活化之致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Roles of microRNAs in Drug Resistance Development of Chronic Myeloid Leukemia

  Shih, C. & Liu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 87%
  • Drug Resistance 40%
  • Imatinib Mesylate 29%
  • ran GTP-Binding Protein 29%

• Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis

  Lin, Y. & Chen, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pulmonary Veins 100%
  • Ivabradine 66%
  • Atrial Fibrillation 48%
  • Sinoatrial Node 40%
  • Cardiac Arrhythmias 27%

• 針對IL-33/ST2訊息路徑調控鈣平衡、內質網壓力與粒線體功能作為心房與肺靜脈心律不整活性與心房顫動致病機轉及治療策略探討(3/3)

  Chen, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對IL-33/ST2訊息路徑調控鈣平衡、內質網壓力與粒線體功能作為心房與肺靜脈心律不整活性與心房顫動致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討新型冠狀病毒棘狀蛋白S1誘導心臟電生理及結構性重塑之病理機制：治療新型冠狀肺炎引發心臟損傷之新契機

  Kao, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討G-CSF於膀胱癌腫瘤微環境所扮演的角色及分子機制

  Wang, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• SOX2-Mediated Oncogenesis and Its Crosstalk with Environmental Risk Factors in Bladder Cancer

  Wang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Urinary Bladder Neoplasms 100%
  • Arsenic 24%
  • Stem Cells 23%
  • Neoplastic Stem Cells 22%
  • Cigarette Smoking 20%

• Molecular Epidemiology of Urothelial Carcinoma Prognosis Based on Microrna Expression Profiles

  Wang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Carcinoma 87%
  • Biomarkers 34%
  • Neoplasms 34%
  • Arsenic 31%

• Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

  Chang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stomach Neoplasms 100%
  • Nicotinic Receptors 76%
  • Nicotine 45%
  • alpha7 Nicotinic Acetylcholine Receptor 19%
  • Therapeutics 18%

• ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(3/3)

  Tsai, K. K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology