Graduate Institute of Biomedical Materials and Tissue Engineering

  • No. 250 Wu-Xing Street,

    11031 Taipei

Research Output 1995 2020

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2020

Effect of cell culture biomaterials for completely xeno-free generation of human induced pluripotent stem cells

Sung, T. C., Li, H. F., Higuchi, A., Kumar, S. S., Ling, Q. D., Wu, Y. W., Burnouf, T., Nasu, M., Umezawa, A., Lee, K. F., Wang, H. C., Chang, Y. & Hsu, S. T., Feb 2020, In : Biomaterials. 230, 119638.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Biocompatible Materials
Amniotic Fluid
Stem cells
Cell culture
Nanofibers
Hydrogel
Hydrogels
Scaffolds
Suspensions
2019
4 Citations (Scopus)

A double-virally-inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells

Barro, L., Su, Y. T., Nebie, O., Wu, Y. W., Huang, Y. H., Koh, M. B. C., Knutson, F. & Burnouf, T., Jan 1 2019, In : Transfusion.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Detergents
Blood Platelets
Serum
In Vitro Techniques
12 Citations (Scopus)

A novel injectable in situ forming gel based on carboxymethyl hexanoyl chitosan/hyaluronic acid polymer blending for sustained release of berberine

Lu, K. Y., Lin, Y. C., Lu, H. T., Ho, Y. C., Weng, S. C., Tsai, M. L. & Mi, F. L., Feb 15 2019, In : Carbohydrate Polymers. 206, p. 664-673 10 p.

Research output: Contribution to journalArticle

Berberine
Hyaluronic acid
Hyaluronic Acid
Chitosan
Polymers

Argon plasma surface modified porcine bone substitute improved osteoblast-like cell behavior

Choy, C. S., Salamanca, E., Lin, P. Y., Huang, H. M., Teng, N. C., Pan, Y. H. & Chang, W. J., Jan 1 2019, In : Coatings. 9, 2, p. 9-134 126 p.

Research output: Contribution to journalArticle

Open Access
Bone Substitutes
osteoblasts
Argon
Osteoblasts
argon plasma

Biodegradation patterns of injected composite bone cements in porcine vertebral bodies: A study using quantitative computed tomography

Yeh, C. C., Chen, C. J., Tang, Y., Yang, K. C. & Wu, C. C., Mar 1 2019, In : Formosan Journal of Surgery. 52, 2, p. 45-51 7 p.

Research output: Contribution to journalArticle

Bone Cements
Swine
Tomography
Spine
Polymethyl Methacrylate
1 Citation (Scopus)
Polyethyleneimine
Polypyrroles
Therapeutic Uses
Reactive Oxygen Species
Lung Neoplasms

CD24 expression indicates healthier phenotype and less tendency of cellular senescence in human nucleus pulposus cells

Yang, S. H., Hu, M. H., Wu, C. C., Chen, C. W., Sun, Y. H. & Yang, K. C., Dec 4 2019, In : Artificial Cells, Nanomedicine and Biotechnology. 47, 1, p. 3021-3028 8 p.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Proteins
Phenotype
Phosphorylation
Sorting

Comparison of transforming growth factor-beta1 and lovastatin on differentiating mesenchymal stem cells toward nucleus pulposus-like phenotype: An in vitro cell culture study

Yang, S. H., Yang, K. C., Chen, C. W., Huang, T. C., Sun, Y. H. & Hu, M. H., Jan 1 2019, In : Asian Spine Journal. 13, 5, p. 705-712 8 p.

Research output: Contribution to journalArticle

Open Access
Transforming Growth Factor beta1
Lovastatin
Cell Nucleus
Mesenchymal Stromal Cells
Cell Culture Techniques
Femoral Fractures
Diphosphonates
Chronic Obstructive Pulmonary Disease
Glucocorticoids
Osteoporosis

Decellularized lymph node scaffolding as a carrier for dendritic cells to induce anti-tumor immunity

Lin, H. J., Wang, W., Huang, Y. Y., Liao, W. T., Lin, T. Y., Lin, S. Y. & Liu, D. Z., Nov 2019, In : Pharmaceutics. 11, 11, 553.

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Immunity
Lymph Nodes
Bone Marrow Cells
Ovalbumin
2 Citations (Scopus)

Development of Decellularized Cornea by Organic Acid Treatment for Corneal Regeneration

Lin, H. J., Wang, T. J., Li, T. W., Chang, Y. Y., Sheu, M. T., Huang, Y. Y. & Liu, D. Z., Apr 1 2019, In : Tissue Engineering - Part A. 25, 7-8, p. 652-662 11 p.

Research output: Contribution to journalArticle

Organic acids
Scaffolds
Cornea
Regeneration
Swine

Development of Kaempferol-loaded gelatin nanoparticles for the treatment of corneal neovascularization in mice

Chuang, Y. L., Fang, H. W., Ajitsaria, A., Chen, K. H., Su, C. Y., Liu, G. S. & Tseng, C. L., Dec 2019, In : Pharmaceutics. 11, 12, 635.

Research output: Contribution to journalArticle

Open Access
Corneal Neovascularization
Gelatin
Nanoparticles
Ophthalmic Solutions
Therapeutics

Effect of Basic Fibroblast Growth Factor on Xenogeneic Islets in Subcutaneous Transplantation—A Murine Model

Yang, S. Y., Yang, K. C. & Sumi, S., Jun 1 2019, In : Transplantation Proceedings. 51, 5, p. 1458-1462 5 p.

Research output: Contribution to journalArticle

Open Access
Fibroblast Growth Factor 2
Islets of Langerhans Transplantation
Equipment and Supplies
Gels
Transplants
1 Citation (Scopus)

Effect of hesperidin on anti-inflammation and cellular antioxidant capacity in hydrogen peroxide-stimulated human articular chondrocytes

Tsai, Y. F., Chen, Y. R., Chen, J. P., Tang, Y. & Yang, K. C., Jan 1 2019, In : Process Biochemistry.

Research output: Contribution to journalArticle

Hesperidin
Chondrocytes
Antioxidants
Hydrogen peroxide
Hydrogen Peroxide

Effects of lysosomal deposition on the friction coefficient of hydrogel contact lenses

Su, C. Y., Yeh, L. K., Lai, C. C., Li, K. Y., Tseng, C. L. & Fang, H. W., Jan 1 2019, (Accepted/In press) In : Contact Lens and Anterior Eye.

Research output: Contribution to journalArticle

Friction
Hydrogel
Contact Lenses
Muramidase
Lenses
1 Citation (Scopus)

Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In : Materials. 12, 4, 569.

Research output: Contribution to journalArticle

Open Access
Assays
Screening
Membranes
Cells
Acids

Enhancement of natural killer cell cytotoxicity by using static magnetic field to increase their viability

Lin, S. L., Su, Y. T., Feng, S. W., Chang, W. J., Fan, K. H. & Huang, H. M., Apr 3 2019, In : Electromagnetic Biology and Medicine. 38, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

Magnetic Fields
Natural Killer Cells
Cell Survival
K562 Cells
MAP Kinase Signaling System

Enumerating circulating tumor cells with a Self-Assembled Cell Array (SACA) Chip: A feasibility study in patients with colorectal cancer

Chu, H. Y., Lu, L. S., Cho, W., Wu, S. Y., Chang, Y. C., Lin, C. P., Yang, C. Y., Lin, C. H., Jiang, J. K. & Tseng, F. G., Jan 1 2019, In : Cancers. 11, 1, 56.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Feasibility Studies
Colorectal Neoplasms
Mesenteric Veins
Veins
12 Citations (Scopus)

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

Agrahari, V., Agrahari, V., Burnouf, P. A., Chew, C. H. & Burnouf, T., Jan 1 2019, (Accepted/In press) In : Trends in Biotechnology.

Research output: Contribution to journalArticle

Biotechnology
Cell- and Tissue-Based Therapy
Industry
State Medicine
Drug Carriers

Extracellular vesicles as nanomedicine: Hopes and hurdles in clinical translation

Burnouf, T., Agrahari, V. & Agrahari, V., Jan 1 2019, In : International Journal of Nanomedicine. 14, p. 8847-8859 13 p.

Research output: Contribution to journalArticle

Open Access
Nanomedicine
Arsenals
Medical nanotechnology
Lipid bilayers
Pharmacokinetics
2 Citations (Scopus)
Wharton Jelly
Detergents
Platelets
Mesenchymal Stromal Cells
Blood Platelets
1 Citation (Scopus)

Gene-Embedded Nanostructural Biotic-Abiotic Optoelectrode Arrays Applied for Synchronous Brain Optogenetics and Neural Signal Recording

Huang, W. C., Chi, H. S., Lee, Y. C., Lo, Y. C., Liu, T. C., Chiang, M. Y., Chen, H. Y., Li, S. J., Chen, Y. Y. & Chen, S. Y., Mar 27 2019, In : ACS Applied Materials and Interfaces. 11, 12, p. 11270-11282 13 p.

Research output: Contribution to journalArticle

Brain
Genes
Polyethyleneimine
Neurotensin
Plasmids

Human adipose-derived stem cell secreted extracellular matrix incorporated into electrospun poly(lactic-co-glycolic acid) nanofibrous dressing for enhancing wound healing

Tang, K. C., Yang, K. C., Lin, C. W., Chen, Y. K., Lu, T. Y., Chen, H. Y., Cheng, N. C. & Yu, J., Oct 1 2019, In : Polymers. 11, 10, 1609.

Research output: Contribution to journalArticle

Open Access
Stem cells
Acids
Skin
Electrospinning
Substrates

Improvement in the biological properties of titanium surfaces with low-temperature plasma

Pan, Y. H., Yao, W. L., Lin, J. C. Y., Salamanca, E., Tsai, P. Y., Leu, S. J., Yang, K. C., Huang, H. M., Teng, N. C. & Chang, W. J., Sep 1 2019, In : Metals. 9, 9, 943.

Research output: Contribution to journalArticle

Open Access
Titanium
Plasmas
Surface properties
Temperature
Adhesion

Incomplete insertion of pedicle screws in a standard construct reduces the fatigue life: A biomechanical analysis

Chu, Y. L., Chen, C. H., Tsuang, F. Y., Chiang, C. J., Wu, Y. & Kuo, Y. J., Jan 1 2019, In : PLoS ONE. 14, 11, e0224699.

Research output: Contribution to journalArticle

Open Access
screws
Fatigue
Fatigue of materials
Finite element method
Tulipa
2 Citations (Scopus)
Tissue regeneration
Electrospinning
Membranes
Surgery
Bone
2 Citations (Scopus)

Keratin scaffolds with human adipose stem cells: Physical and biological effects toward wound healing

Lin, C. W., Chen, Y. K., Tang, K. C., Yang, K. C., Cheng, N. C. & Yu, J., Jun 1 2019, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 6, p. 1044-1058 15 p.

Research output: Contribution to journalArticle

Keratin
Scaffolds (biology)
Keratins
Stem cells
Scaffolds
1 Citation (Scopus)

NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety

Obeid, S., Sung, P. S., Le Roy, B., Chou, M. L., Hsieh, S. L., Elie-Caille, C., Burnouf, T. & Boireau, W., Aug 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 20, p. 101977 101977.

Research output: Contribution to journalArticle

Plasma (human)
Safety
Plasmas
Nanofiltration
Biochips
5 Citations (Scopus)
Nanomedicine
Artificial Cells
Elasticity
Brain
Biological Factors

Past and future of neurotrophic growth factors therapies in ALS: From single neurotrophic growth factor to stem cells and human platelet lysates

Gouel, F., Rolland, A. S., Devedjian, J. C., Burnouf, T. & Devos, D., Jan 1 2019, In : Frontiers in Neurology. 10, JUL, 835.

Research output: Contribution to journalArticle

Open Access
Nerve Growth Factors
Amyotrophic Lateral Sclerosis
Intercellular Signaling Peptides and Proteins
Stem Cells
Blood Platelets
Open Access
Continuous wave lasers
continuous wave lasers
Liquids
liquids
printing

Poly-gamma-glutamic acid functions as an effective lubricant with antimicrobial activity in multipurpose contact lens care solutions

Su, C. Y., Tseng, C. L., Wu, S. H., Shih, B. W., Chen, Y. Z. & Fang, H. W., Jun 1 2019, In : Polymers. 11, 6, 1050.

Research output: Contribution to journalArticle

Open Access
Contact lenses
Lubricants
Prostaglandins A
Acids
Functional polymers
2 Citations (Scopus)

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses

You, G. R., Cheng, A. J., Lee, L. Y., Huang, Y. C., Liu, H., Chen, Y. J. & Chang, J. T., Jan 14 2019, In : BMC Cancer. 19, 1, 64.

Research output: Contribution to journalArticle

Open Access
Head and Neck Neoplasms
Computational Biology
Atlases
Radiotherapy
Genome
1 Citation (Scopus)

Repeated-batch lactic acid fermentation using a novel bacterial immobilization technique based on a microtube array membrane

Chen, C. C., Lan, C. C., Pan, C. L., Huang, M. Y., Chew, C. H., Hung, C. C., Chen, P. H. & Lin, H. T. V., Dec 2019, In : Process Biochemistry. 87, p. 25-32 8 p.

Research output: Contribution to journalArticle

Lactic acid
Immobilization
Fermentation
Lactic Acid
Membranes

Strategy on Persisting in Distinct Activity of Plasmon-Activated Water

Yang, C. P., Tsai, H. Y., Tseng, C. L., Hao, P. J. & Liu, Y. C., Dec 17 2019, In : ACS Omega. 4, 25, p. 21197-21203 7 p.

Research output: Contribution to journalArticle

Open Access
Water
Deionized water
Liquids
Liquid nitrogen
Vapor pressure

The chondroprotective effect of diosmin on human articular chondrocytes under oxidative stress

Chen, Y. R., Yang, K. C., Lu, D. H., Wu, W. T., Wang, C. C. & Tsai, M. H., Jan 1 2019, In : Phytotherapy Research.

Research output: Contribution to journalArticle

Diosmin
Chondrocytes
Oxidative Stress
Joints
Matrix Metalloproteinases

The effect of human platelet lysate on the differentiation ability of human adipose-derived stem cells cultured on ECM-coated surfaces

Gao, Y., Ku, N. J., Sung, T. C., Higuchi, A., Hung, C. S., Lee, H. H. C., Ling, Q. D., Cheng, N. C., Umezawa, A., Barro, L., Burnouf, T., Ye, Q. & Chen, H., Jan 1 2019, In : Journal of Materials Chemistry B. 7, 45, p. 7110-7119 10 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Platelets
Stem cells
Proteins
Vitronectin
Open Access
stem cells
Cell proliferation
Stem cells
Mesenchymal Stromal Cells
Cell culture

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Nebie, O., Devos, D., Vingtdeux, V., Barro, L., Devedjian, J. C., Jonneaux, A., Chou, M. L., Bordet, R., Buée, L., Knutson, F., Blum, D. & Burnouf, T., Oct 31 2019, In : Journal of Biomedical Science. 26, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Biocompatible Materials
Pathogens
Platelets
Blood Platelets
Hot Temperature

Thermosensitive magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted brain tumor chemotherapy

Lu, Y. J., Chuang, E. Y., Cheng, Y. H., Anilkumar, T. S., Chen, H. A. & Chen, J. P., Oct 1 2019, In : Chemical Engineering Journal. 373, p. 720-733 14 p.

Research output: Contribution to journalArticle

irinotecan
chemotherapy
Chemotherapy
Liposomes
Drug delivery

The role of nanofiltration in the pathogen safety of biologicals: an update

Inouye, M. & Burnouf, T. P. R., 2019, In : Current Nanoscience.

Research output: Contribution to journalArticle

Nanofiltration
Pathogens
Viruses
Technology
Safety
1 Citation (Scopus)
Finite Element Analysis
finite element analysis
Bone
bones
Finite element method
2 Citations (Scopus)

The therapeutic effect of aucubin-supplemented hyaluronic acid on interleukin-1beta-stimulated human articular chondrocytes

Huang, T. L., Yang, S. H., Chen, Y. R., Liao, J. Y., Tang, Y. & Yang, K. C., Feb 1 2019, In : Phytomedicine. 53, p. 1-8 8 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Hyaluronic Acid
Chondrocytes
Interleukin-1beta
Joints

Three-dimensional spherical gelatin bubble-based scaffold improves the myotube formation of H9c2 myoblasts

Mei, C., Chao, C. W., Lin, C. W., Li, S. T., Wu, K. H., Yang, K. C. & Yu, J., Jan 1 2019, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalArticle

Myoblasts
Skeletal Muscle Fibers
Gelatin
Scaffolds
Substrates

Ultrasound-Guided Minimally Invasive Surgical Resection of Retrocalcaneal Bursitis: A Preliminary Comparison With Traditional Open Surgery

Wang, C. L., Chen, P. Y., Yang, K. C., Wu, H. C. & Wang, C. C., Sep 2019, In : Journal of Foot and Ankle Surgery. 58, 5, p. 855-860 6 p.

Research output: Contribution to journalArticle

Bursitis
Minimally Invasive Surgical Procedures
Pain
Heel
Ankle
2018
2 Citations (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journalArticle

Sirtuin 1
Dental Pulp
AMP-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Stem Cells
3 Citations (Scopus)

A gelatin hydrogel-containing nano-organic PEI–Ppy with a photothermal responsive effect for tissue engineering applications

Satapathy, M. K., Nyambat, B., Chiang, C. W., Chen, C. H., Wong, P. C., Ho, P. H., Jheng, P. R., Burnouf, T., Tseng, C. L. & Chuang, E. Y., Jan 1 2018, In : Molecules. 23, 6, 1256.

Research output: Contribution to journalArticle

tissue engineering
Hydrogel
gelatins
Gelatin
Tissue Engineering
4 Citations (Scopus)

A Microtube Array Membrane (MTAM) Encapsulated Live Fermenting Staphylococcus epidermidis as a Skin Probiotic Patch against Cutibacterium acnes

Yang, A-J., Marito, S., Yang, J-J., Keshari, S., Chew, C-H., Chen, C-C. & Huang, C-M., Dec 20 2018, In : International Journal of Molecular Sciences. 20, 1

Research output: Contribution to journalArticle

Staphylococcus epidermidis
staphylococcus
Acne Vulgaris
Probiotics
Skin
3 Citations (Scopus)

An Intestinal "transformers"-like Nanocarrier System for Enhancing the Oral Bioavailability of Poorly Water-Soluble Drugs

Chuang, E. Y., Lin, K. J., Huang, T. Y., Chen, H. L., Miao, Y. B., Lin, P. Y., Chen, C. T., Juang, J. H. & Sung, H. W., Jul 24 2018, In : ACS Nano. 12, 7, p. 6389-6397 9 p.

Research output: Contribution to journalArticle

bioavailability
Curcumin
transformers
drugs
Water