Division of Hematology and Oncology

Research Output

2016

Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry

Chung, C. Y., Liu, C. H., Burnouf, T., Wang, G. H., Chang, S. P., Jassey, A., Tai, C. J., Tai, C. J., Huang, C. J., Richardson, C. D., Yen, M. H., Lin, C. C. & Lin, L. T., Jun 1 2016, In : Antiviral Research. 130, p. 58-68 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Anti-cancer activity of Solanum nigrum (AESN) through suppression of mitochondrial function and epithelial-mesenchymal transition (EMT) in breast cancer cells

Lai, Y. J., Tai, C. J., Wang, C. W., Choong, C. Y., Lee, B. H., Shi, Y. C. & Tai, C. J., May 1 2016, In : Molecules. 21, 5, 553.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Aqueous extract of Paris polyphylla (AEPP) inhibits ovarian cancer via suppression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha

Wang, C. W., Tai, C. J., Choong, C. Y., Lin, Y. C., Lee, B. H., Shi, Y. C. & Tai, C. J., Jun 1 2016, In : Molecules. 21, 6, 727.

Research output: Contribution to journalArticle

11 Citations (Scopus)
8 Citations (Scopus)
8 Citations (Scopus)

Curative-Intent Aggressive Treatment Improves Survival in Elderly Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma and High Comorbidity Index

Chen, J. H., Yen, Y. C., Yang, H. C., Liu, S. H., Yuan, S. P., Wu, L. L., Lee, F. P., Lin, K. C., Lai, M. T., Wu, C. C., Chen, T. M., Chang, C. L., Chow, J. M., Ding, Y. F. & Wu, S. Y., Apr 1 2016, In : Medicine (United States). 95, 14, e3268.

Research output: Contribution to journalArticle

28 Citations (Scopus)
17 Citations (Scopus)

Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma

Wei, P-L., Huang, C. Y., Tai, C-J., Batzorig, U., Cheng, W. L., Hunag, M. T. & Chang, Y-J., Jun 1 2016, In : Tumor Biology. 37, 6, p. 8219-8227 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Highly diverse efficacy of salvage treatment regimens for relapsed or refractory peripheral T-cell lymphoma: A systematic review

Yang, Y. T., Tai, C-J., Chen, C-F., Wu, H. C., Mikhaylichenko, N., Chiu, H. T., Chen, Y-Y. & Hsu, Y-H., Oct 1 2016, In : PLoS One. 11, 10

Research output: Contribution to journalReview article

6 Citations (Scopus)
47 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Maspin mediates the gemcitabine sensitivity of hormone-independent prostate cancer

Huang, C. Y., Chang, Y. J., Luo, S. D., Uyanga, B., Lin, F. Y., Tai, C. J. & Huang, M. T., Mar 1 2016, In : Tumor Biology. 37, 3, p. 4075-4082

Research output: Contribution to journalArticle

2 Citations (Scopus)

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In : RNA. 22, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Outcomes of induction chemotherapy for head and neck cancer patients a combined study of two national cohorts in Taiwan

Chen, J-H., Yen, Y-C., Liu, S. H., Yuan, S. P., Wu, L. L., Lee, F-P., Lin, K. C., Lai, M-T., Wu, C-C., Chen, T. M., Chang, C. L., Chow, J-M., Ding, Y. F., Lin, M-C. & Wu, S-Y., 2016, In : Medicine (United States). 95, 7, p. e2845

Research output: Contribution to journalArticle

19 Citations (Scopus)
13 Citations (Scopus)
12 Citations (Scopus)

Solanum nigrum protects against hepatic fibrosis via suppression of hyperglycemia in high-fat/ethanol diet-induced rats

Tai, C. J., Choong, C. Y., Shi, Y. C., Lin, Y. C., Wang, C-W., Lee, B. H. & Tai, C. J., Mar 1 2016, In : Molecules. 21, 3, 269.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Statins improve outcomes of nonsurgical curative treatments in hepatocellular carcinoma patients

Wu, L. L., Hsieh, M. C., Chow, J. M., Liu, S. H., Chang, C. L. & Wu, S. Y., 2016, In : Medicine (United States). 95, 36, e4639.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The anti-hepatic fibrosis activity of ergosterol depended on upregulation of PPARgamma in HSC-T6 cells

Tai, C. J., Choong, C. Y., Lin, Y. C., Shi, Y. C. & Tai, C. J., Apr 1 2016, In : Food and Function. 7, 4, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

13 Citations (Scopus)

Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells

Tai, C. J., Wang, C. W., Chen, C. L., Wang, C. K., Chang, Y. J., Jian, J. Y., Lin, C. S. & Tai, C. J., Nov 1 2015, In : Integrative Cancer Therapies. 14, 6, p. 546-555 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Early viral entry assays for the identification and evaluation of antiviral compounds

Tai, C. J., Li, C. L., Tai, C. J., Wang, C. K. & Lin, L. T., Oct 29 2015, In : Journal of Visualized Experiments. 2015, 104, e53124.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effects of symptoms and complementary and alternative medicine use on the yang deficiency pattern among breast cancer patients receiving chemotherapy

Huang, S. M., Chien, L. Y., Tai, C. J., Chen, P. H., Lien, P. J. & Tai, C. J., Apr 1 2015, In : Complementary Therapies in Medicine. 23, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
15 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
9 Citations (Scopus)
10 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
8 Citations (Scopus)

The impact of pain control on physical and psychiatric functions of cancer patients: A nation-wide survey in Taiwan

Rau, K. M., Chen, J. S., Wu, H. B., Lin, S. F., Lai, M. K., Chow, J. M., Huang, M. L., Wang, C. J., Tai, C. J., Hwang, W. L., Lu, Y. C., Chan, C. H. & Hsieh, R. K., 2015, In : Japanese Journal of Clinical Oncology. 45, 11, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
14 Citations (Scopus)
2014

A multicenter phase II study of biweekly capecitabine in combination with oxaliplatin as first-line chemotherapy in patients with locally advanced or metastatic gastric cancer

Chao, Y., Hsieh, J. S., Yeh, H. T., Su, Y. C., Wu, C. C., Chen, J. S., Tai, C. J., Bai, L. Y., Yeh, K. H., Su, W. C. & Li, C. P., 2014, In : Cancer Chemotherapy and Pharmacology. 73, 4, p. 799-806 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
11 Citations (Scopus)

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells

Tai, C. J., Wang, J. W., Su, H. Y., Tai, C. J., Wang, C. K., Wu, C. T., Lien, Y. C. & Chang, Y. J., Jan 2014, In : Tumor Biology. 35, 1, p. 403-410 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., 2014, In : Oncotarget. 5, 11, p. 3770-3784 15 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines

Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In : PLoS One. 9, 8, e105342.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The effect of mushroom beta-glucans from solid culture of ganoderma lucidum on inhibition of the primary tumor metastasis

Chen, S. N., Chang, C. S., Hung, M. H., Chen, S., Wang, W., Tai, C. J. & Lu, C. L., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 252171.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkers

Tai, C-J., Cheng, C-W., Su, H. Y., Chen, W-Y., Wu, C. T., Lin, F-Y., Wang, C. K., Tai, C-J. & Wei, P-L., Jan 2014, In : Tumor Biology. 35, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

A comparative study of symptoms and quality of life among patients with breast cancer receiving target, chemotherapy, or combined therapy

Huang, S. M., Tai, C-J., Lin, K. C., Tai, C-J., Tseng, L. M. & Chien, L. Y., Jul 2013, In : Cancer Nursing. 36, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adjuvant trastuzumab for 6 months is effective in patients with HER2-positive stage II or III breast cancer

Tai, C. J., Pan, C. K., Chen, C. S., Hung, C. S., Wu, C. H. & Chiou, H. Y., 2013, In : Asian Pacific Journal of Cancer Prevention. 14, 3, p. 1981-1984 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
42 Citations (Scopus)

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In : Oncology Reports. 30, 3, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development

Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.

Research output: Contribution to journalArticle

24 Citations (Scopus)