Division of Hematology and Oncology

Research Output 1990 2019

2016
29 Citations (Scopus)

Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis

Lin, C. W., Yang, W. E., Lee, W. J., Hua, K. T., Hsieh, F. K., Hsiao, M., Chen, C. C., Chow, J. M., Chen, M. K., Yang, S. F. & Chien, M. H., Jul 1 2016, In : Carcinogenesis. 37, 7, p. 712-722 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Cell Movement
MicroRNAs
2 Citations (Scopus)

Maspin mediates the gemcitabine sensitivity of hormone-independent prostate cancer

Huang, C. Y., Chang, Y. J., Luo, S. D., Uyanga, B., Lin, F. Y., Tai, C. J. & Huang, M. T., Mar 1 2016, In : Tumor Biology. 37, 3, p. 4075-4082

Research output: Contribution to journalArticle

gemcitabine
Prostatic Neoplasms
Hormones
B-Cell Lymphoma
Apoptosis
18 Citations (Scopus)

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In : RNA. 22, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Lung Neoplasms
Activating Transcription Factors
Apoptosis
MAP Kinase Signaling System
17 Citations (Scopus)

Outcomes of induction chemotherapy for head and neck cancer patients a combined study of two national cohorts in Taiwan

Chen, J-H., Yen, Y-C., Liu, S. H., Yuan, S. P., Wu, L. L., Lee, F-P., Lin, K. C., Lai, M-T., Wu, C-C., Chen, T. M., Chang, C. L., Chow, J-M., Ding, Y. F., Lin, M-C. & Wu, S-Y., 2016, In : Medicine (United States). 95, 7, p. e2845

Research output: Contribution to journalArticle

Induction Chemotherapy
Head and Neck Neoplasms
Taiwan
docetaxel
Chemoradiotherapy
8 Citations (Scopus)
Lymph Node Excision
Meta-Analysis
Randomized Controlled Trials
Breast Neoplasms
Neoplasm Metastasis
10 Citations (Scopus)
Cyclin-Dependent Kinases
Colorectal Neoplasms
Diphosphates
Deoxyribonucleosides
Ribonucleosides
Tunica Intima
Heart Atria
Sarcoma
Recurrence
Manuscripts
5 Citations (Scopus)

Solanum nigrum protects against hepatic fibrosis via suppression of hyperglycemia in high-fat/ethanol diet-induced rats

Tai, C. J., Choong, C. Y., Shi, Y. C., Lin, Y. C., Wang, C-W., Lee, B. H. & Tai, C. J., Mar 1 2016, In : Molecules. 21, 3, 269.

Research output: Contribution to journalArticle

Solanum nigrum
hyperglycemia
fibrosis
diets
fats
15 Citations (Scopus)

Statins improve outcomes of nonsurgical curative treatments in hepatocellular carcinoma patients

Wu, L. L., Hsieh, M. C., Chow, J. M., Liu, S. H., Chang, C. L. & Wu, S. Y., 2016, In : Medicine (United States). 95, 36, e4639.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hepatocellular Carcinoma
Ethanol
Injections
Therapeutics
5 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Drug Discovery
Genomics
Polypharmacology
5 Citations (Scopus)

The anti-hepatic fibrosis activity of ergosterol depended on upregulation of PPARgamma in HSC-T6 cells

Tai, C. J., Choong, C. Y., Lin, Y. C., Shi, Y. C. & Tai, C. J., Apr 1 2016, In : Food and Function. 7, 4, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

Ergosterol
Hepatic Stellate Cells
liver cirrhosis
ergosterol
PPAR gamma
2015
9 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

Nicotinic Receptors
Fluorouracil
Stomach Neoplasms
In Situ Nick-End Labeling
Cell Cycle
11 Citations (Scopus)

Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells

Tai, C. J., Wang, C. W., Chen, C. L., Wang, C. K., Chang, Y. J., Jian, J. Y., Lin, C. S. & Tai, C. J., Nov 1 2015, In : Integrative Cancer Therapies. 14, 6, p. 546-555 10 p.

Research output: Contribution to journalArticle

docetaxel
Solanum nigrum
Doxorubicin
Cisplatin
Ovarian Neoplasms
9 Citations (Scopus)

Early viral entry assays for the identification and evaluation of antiviral compounds

Tai, C. J., Li, C. L., Tai, C. J., Wang, C. K. & Lin, L. T., Oct 29 2015, In : Journal of Visualized Experiments. 2015, 104, e53124.

Research output: Contribution to journalArticle

Antiviral agents
Antiviral Agents
Assays
Virus Inactivation
Viruses
7 Citations (Scopus)

Effects of symptoms and complementary and alternative medicine use on the yang deficiency pattern among breast cancer patients receiving chemotherapy

Huang, S. M., Chien, L. Y., Tai, C. J., Chen, P. H., Lien, P. J. & Tai, C. J., Apr 1 2015, In : Complementary Therapies in Medicine. 23, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Yang Deficiency
Complementary Therapies
Meridians
Breast Neoplasms
Drug Therapy
14 Citations (Scopus)
Solanum nigrum
Doxorubicin
Cisplatin
Hepatocellular Carcinoma
Drug Therapy
20 Citations (Scopus)

Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein

Chien, M. H., Lee, W. J., Hsieh, F. K., Li, C. F., Cheng, T. Y., Wang, M. Y., Chen, J. S., Chow, J. M., Jan, Y. H., Hsiao, M., Hua, K. T. & Kuo, M. L., Oct 15 2015, In : Clinical Cancer Research. 21, 20, p. 4719-4732 14 p.

Research output: Contribution to journalArticle

Protein Transport
Cell Movement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Kelch-Like ECH-Associated Protein 1
8 Citations (Scopus)
Drug Combinations
docetaxel
Carcinoma
Neoplasms
Cisplatin
9 Citations (Scopus)

Primary leptomeningeal melanoma mimicking meningitis: A case report and literature review

Hsieh, Y. Y., Yang, S. T., Li, W. H., Hu, C. J. & Wang, L. S., Apr 20 2015, In : Journal of Clinical Oncology. 33, 12, p. e57-e61

Research output: Contribution to journalArticle

Meningeal Neoplasms
Viral Meningitis
Meningitis
Melanoma
Differential Diagnosis
9 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
8 Citations (Scopus)
Antrodia
Cytotoxicity
Cell Cycle Checkpoints
Doxorubicin
Cisplatin
9 Citations (Scopus)

The impact of pain control on physical and psychiatric functions of cancer patients: A nation-wide survey in Taiwan

Rau, K. M., Chen, J. S., Wu, H. B., Lin, S. F., Lai, M. K., Chow, J. M., Huang, M. L., Wang, C. J., Tai, C. J., Hwang, W. L., Lu, Y. C., Chan, C. H. & Hsieh, R. K., 2015, In : Japanese Journal of Clinical Oncology. 45, 11, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

Taiwan
Psychiatry
Pain
Neoplasms
Ambulatory Care Facilities
12 Citations (Scopus)
Matrix Metalloproteinase 2
Glioblastoma
Modulation
Matrix Metalloproteinases
Proteins
2014
9 Citations (Scopus)

A multicenter phase II study of biweekly capecitabine in combination with oxaliplatin as first-line chemotherapy in patients with locally advanced or metastatic gastric cancer

Chao, Y., Hsieh, J. S., Yeh, H. T., Su, Y. C., Wu, C. C., Chen, J. S., Tai, C. J., Bai, L. Y., Yeh, K. H., Su, W. C. & Li, C. P., 2014, In : Cancer Chemotherapy and Pharmacology. 73, 4, p. 799-806 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Chemotherapy
Stomach Neoplasms
Toxicity
Drug Therapy
9 Citations (Scopus)
Camptotheca
Camptothecin
Endometrial Neoplasms
Fruit
Cisplatin
5 Citations (Scopus)

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Side-Population Cells
temozolomide
Neoplastic Stem Cells
Glioma

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Oxidative stress
Medicine
Free Radicals
8 Citations (Scopus)

Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells

Tai, C. J., Wang, J. W., Su, H. Y., Tai, C. J., Wang, C. K., Wu, C. T., Lien, Y. C. & Chang, Y. J., Jan 2014, In : Tumor Biology. 35, 1, p. 403-410 8 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Therapeutics
Apoptosis
bcl-Associated Death Protein
glucose-regulated proteins
36 Citations (Scopus)

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., 2014, In : Oncotarget. 5, 11, p. 3770-3784 15 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Protein-Tyrosine Kinases
Prostatic Neoplasms
Neoplasm Metastasis
Apoptosis Regulatory Proteins
22 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

Caspase 9
Caspase 8
Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
31 Citations (Scopus)

Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines

Hsiao, P. C., Chou, Y. E., Tan, P., Lee, W-J., Yang, S. F., Chow, J-M., Chen, H. Y., Lin, C-H., Lee, L-M. & Chien, M-H., Aug 21 2014, In : PLoS One. 9, 8, e105342.

Research output: Contribution to journalArticle

myeloid leukemia
Cell Cycle Resting Phase
G1 Phase
Myeloid Cells
Acute Myeloid Leukemia
8 Citations (Scopus)

The effect of mushroom beta-glucans from solid culture of ganoderma lucidum on inhibition of the primary tumor metastasis

Chen, S. N., Chang, C. S., Hung, M. H., Chen, S., Wang, W., Tai, C. J. & Lu, C. L., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 252171.

Research output: Contribution to journalArticle

Reishi
beta-Glucans
Agaricales
Lewis Lung Carcinoma
Neoplasm Metastasis
9 Citations (Scopus)

Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkers

Tai, C-J., Cheng, C-W., Su, H. Y., Chen, W-Y., Wu, C. T., Lin, F-Y., Wang, C. K., Tai, C-J. & Wei, P-L., Jan 2014, In : Tumor Biology. 35, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Thrombomodulin
Epithelial-Mesenchymal Transition
Uterine Cervical Neoplasms
Biomarkers
HeLa Cells
2013
13 Citations (Scopus)

A comparative study of symptoms and quality of life among patients with breast cancer receiving target, chemotherapy, or combined therapy

Huang, S. M., Tai, C-J., Lin, K. C., Tai, C-J., Tseng, L. M. & Chien, L. Y., Jul 2013, In : Cancer Nursing. 36, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

Quality of Life
Breast Neoplasms
Drug Therapy
Therapeutics
Group Psychotherapy
6 Citations (Scopus)

Adjuvant trastuzumab for 6 months is effective in patients with HER2-positive stage II or III breast cancer

Tai, C. J., Pan, C. K., Chen, C. S., Hung, C. S., Wu, C. H. & Chiou, H. Y., 2013, In : Asian Pacific Journal of Cancer Prevention. 14, 3, p. 1981-1984 4 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Chills
Trastuzumab
Dizziness
Therapeutics
37 Citations (Scopus)
docetaxel
Solanum nigrum
Autophagy
Fluorouracil
Doxorubicin
11 Citations (Scopus)

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In : Oncology Reports. 30, 3, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Methotrexate
Aspirin
Lung Neoplasms
Tetrahydrofolate Dehydrogenase
S Phase
24 Citations (Scopus)

Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development

Lin, C. W., Chuang, C. Y., Tang, C. H., Chang, J. L., Lee, L-M., Lee, W-J., Chow, J-M., Yang, S. F. & Chien, M-H., Sep 12 2013, In : PLoS One. 8, 9, e72940.

Research output: Contribution to journalArticle

Environmental Carcinogens
Mouth Neoplasms
carcinogens
Intercellular Adhesion Molecule-1
Polymorphism
13 Citations (Scopus)

Correlations between cytoplasmic CSE1L in neoplastic colorectal glands and depth of tumor penetration and cancer stage

Tai, C. J., Su, T. C., Jiang, M. C., Chen, H. C., Shen, S. C., Lee, W. R., Liao, C. F., Chen, Y. C., Lin, S. H., Li, L. T., Shen, K. H., Yeh, C. M., Yeh, K. T., Lee, C. H., Shih, H. Y. & Chang, C. C., Jan 31 2013, In : Journal of Translational Medicine. 11, 1, 29.

Research output: Contribution to journalArticle

Tumors
Cells
Colorectal Neoplasms
Cellular Apoptosis Susceptibility Protein
Neoplasm Metastasis
12 Citations (Scopus)

CSE1L modulates ras-induced cancer cell invasion: Correlation of K-ras mutation and CSE1L expression in colorectal cancer progression

Jiang, M. C., Yeh, C. M., Tai, C. J., Chen, H. C., Lin, S. H., Su, T. C., Shen, S. C., Lee, W. R., Liao, C. F., Li, L. T., Lee, C. H., Chen, Y. C., Yeh, K. T. & Chang, C. C., Sep 2013, In : American Journal of Surgery. 206, 3, p. 418-427 10 p.

Research output: Contribution to journalArticle

Chromosome Segregation
Chromosomes, Human, Pair 1
Colorectal Neoplasms
Mutation
Neoplasms
15 Citations (Scopus)
Breast Neoplasms
Drug Therapy
Leukocyte Count
Teaching Hospitals
Hemoglobins
13 Citations (Scopus)
Fluorouracil
Cisplatin
Hepatocellular Carcinoma
Cell Death
Neoplasms
11 Citations (Scopus)

High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer

Tai, C. J., Lee, C. H., Chen, H. C., Wang, H. K., Jiang, M. C., Su, T. C., Shen, K. H., Lin, S. H., Yeh, C. M., Chen, C. J., Yeh, K. T. & Chang, C. C., Apr 2013, In : Annals of Diagnostic Pathology. 17, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Colorectal Neoplasms
Neoplasms
Adenoma
Cell Nucleus
3 Citations (Scopus)

High nuclear phosphorylated extracellular signal-regulated kinase expression associated with poor differentiation, larger tumor size, and advanced stage of breast cancer

Kuo, H. T., Hsu, H. T., Chang, C. C., Jiang, M. C., Yeh, C. M., Shen, K. H., Hsu, P. C. & Tai, C. J., 2013, In : Polish Journal of Pathology. 64, 3, p. 163-169 7 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Breast Neoplasms
Neoplasms
Biomarkers
Mitogen-Activated Protein Kinase 1
27 Citations (Scopus)
caspase-8
myeloid leukemia
Caspase 9
Caspase 8
Myeloid Cells
28 Citations (Scopus)
Catenins
Neoplastic Stem Cells
Mouth Neoplasms
Side-Population Cells
Apoptosis
41 Citations (Scopus)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In : Oncology Letters. 6, 5, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Apoptosis
lissamine rhodamine B
Cell Line
2 Citations (Scopus)

Increases in Xu Zheng and Yu Zheng among patients with breast cancer receiving different anticancer drug therapies

Tai, C. J., Huang, S. M., Chien, L. Y., Tai, C. J., Tseng, L. M. & Chen, P. H., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 392024.

Research output: Contribution to journalArticle

Yin Deficiency
Yang Deficiency
Breast Neoplasms
Drug Therapy
Therapeutics
15 Citations (Scopus)

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

Mefloquine
Extracellular Signal-Regulated MAP Kinases
Adenosine Monophosphate
Protein Kinases
Reactive Oxygen Species