Division of Hematology and Oncology

Research Output

2020

ABL genomic editing sufficiently abolishes oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo

Chen, S. H., Hsieh, Y. Y., Tzeng, H. E., Lin, C. Y., Hsu, K. W., Chiang, Y. S., Lin, S. M., Su, M. J., Hsieh, W. S. & Lee, C. H., Jun 2020, In : Cancers. 12, 6, 1399.

Research output: Contribution to journal › Article

Open Access

Impacts of RETN genetic polymorphism on breast cancer development

Wang, C. Q., Tang, C. H., Tzeng, H. E., Jin, L., Zhao, J., Kang, L., Wang, Y., Hu, G. N., Huang, B. F., Li, X., Zhao, Y. M., Su, C. M. & Jin, H. C., Jan 1 2020, In : Journal of Cancer. 11, 10, p. 2769-2777 9 p.

Research output: Contribution to journal › Article

Open Access

Limited effects of antibiotic prophylaxis in patients with Child–Pugh class A/B cirrhosis and upper gastrointestinal bleeding

Chang, T. S., Tsai, Y. H., Lin, Y. H., Chen, C. H., Lu, C. K., Huang, W. S., Yang, Y. H., Chen, W. M., Hsieh, Y. Y., Wu, Y. C., Tung, S. Y. & Huang, Y. H., Jan 1 2020, In : PLoS ONE. 15, 2, e0229101.

Research output: Contribution to journal › Article

Open Access

Taiwanofungus camphoratus Combined With Amphotericin B for Metastatic Cancer Patients Unresponsive to or Unwilling to Undergo Chemotherapy: A pilot study

Tai, C. J., Shi, Y. C., Tai, C. J., Kuo, L. J., Chen, R. J., Chang, Y. J., Tzao, C., Wu, C. H., Chang, C. C., Chiou, H. Y. & Su, C. H., Mar 1 2020, In : Alternative Therapies in Health and Medicine. 24, 12, p. 18-22

Research output: Contribution to journal › Article

1 Citation (Scopus)

Tumor-infiltrating leukocytes suppress local inflammation via interleukin-1 receptor antagonist in a syngeneic prostate cancer model

Fan, Y. C., Chen, W. Y., Lee, K. D. & Tsai, Y. C., Apr 2020, In : Biology. 9, 4, 67.

Research output: Contribution to journal › Article

Open Access
2019

Adjuvant therapy for high-risk stage ii or iii colon adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study

Chang, C. L., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., Dec 2019, In : Cancers. 11, 12, 2003.

Research output: Contribution to journal › Article

Open Access

Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

Tai, C. J., Liu, C. H., Pan, Y. C., Wong, S. H., Tai, C. J., Richardson, C. D. & Lin, L. T., Dec 1 2019, In : Scientific Reports. 9, 1, 6767.

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)

Comparing the effectiveness of different EGFR-TKIs in patients with EGFR mutant non–small-cell lung cancer: A retrospective cohort study in Taiwan

Hsieh, Y. Y., Fang, W. T., Lo, Y. W., Chen, Y. H. & Chien, L. N., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journal › Article

HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells

Chen, S. H., Chow, J. M., Hsieh, Y. Y., Lin, C. Y., Hsu, K. W., Hsieh, W. S., Chi, W. M., Shabangu, B. M. & Lee, C. H., May 1 2019, In : International Journal of Molecular Sciences. 20, 9, 2271.

Research output: Contribution to journal › Article

Open Access
6 Citations (Scopus)

In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma

Hsieh, Y. Y., Liu, T. P. & Yang, P. M., Jan 1 2019, In : Pathology Research and Practice.

Research output: Contribution to journal › Article

Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma

Hsieh, Y. Y., Liu, T. P., Chou, C. J., Chen, H. Y., Lee, K. H. & Yang, P. M., Sep 28 2019, In : Genes. 10, 10

Research output: Contribution to journal › Article

Open Access
1 Citation (Scopus)

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)

Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2/MyD88 Signal against Cell Proliferation

Uen, W. C., Choong, C. Y., Tai, C. J. & Tai, C. J., Jan 1 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, 7035087.

Research output: Contribution to journal › Article

Open Access

Paris polyphylla inhibits colorectal cancer cells via inducing autophagy and enhancing the efficacy of chemotherapeutic drug doxorubicin

Lin, L. T., Uen, W. C., Choong, C. Y., Shi, Y. C., Lee, B. H., Tai, C. J. & Tai, C. J., Jun 3 2019, In : Molecules. 24, 11, 2102.

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)

Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Lin, R. K., Choong, C. Y., Hsu, W. H., Tai, C. J. & Tai, C. J., Jun 2019, In : African Health Sciences. 19, 2, p. 2156-2163 8 p.

Research output: Contribution to journal › Article

Open Access
1 Citation (Scopus)

Testicular mixed germ cell tumor presenting with seizure as the initial symptom: A case report and literature review

Syu, S. H., Chang, C. L. & Shih, H. J., May 1 2019, In : International Braz J Urol. 45, 3, p. 629-633 5 p.

Research output: Contribution to journal › Article

Open Access

Toxicity profiles of fractionated radiotherapy, contemporary stereotactic radiosurgery, and transsphenoidal surgery in nonfunctioning pituitary macroadenomas

Chang, C. L., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., Nov 2019, In : Cancers. 11, 11, 1658.

Research output: Contribution to journal › Article

Open Access

Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: A case report

Kuo, C. Y., Lin, S. H., Lee, K. D., Cheng, S. J., Chu, J. S. & Tu, S. H., Jul 27 2019, In : BMC Surgery. 19, 1, 100.

Research output: Contribution to journal › Article

Open Access
2018

A Phase I/II study of the combination of lapatinib and oral vinorelbine in HER2-positive metastatic breast cancer

Chen, T. W-W., Yeh, D-C., Chao, T-Y., Lin, C-H., Chow, L. W-C., Chang, D-Y., Hsieh, Y-Y., Huang, S-M., Cheng, A-L. & Lu, Y-S., Mar 1 2018, In : Japanese Journal of Clinical Oncology. 48, 3, p. 242-247 6 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway

Wang, S. C., Chow, J. M., Chien, M. H., Lin, C. W., Chen, H. Y., Hsiao, P. C. & Yang, S. F., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journal › Article

13 Citations (Scopus)

Cordycepin suppressed lipid accumulation via regulating AMPK activity and mitochondrial fusion in hepatocytes

Uen, W-C., Shi, Y-C., Choong, C-Y. & Tai, C-J., Aug 15 2018, In : Journal of Food Biochemistry. 0, 0, p. e12569

Research output: Contribution to journal › Article

2 Citations (Scopus)

Correction: Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance [Oncotarget. 5, (2014), 3770-3784]doi 10.18632/oncotarget.1994

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., Aug 17 2018, In : Oncotarget. 9, 64, p. 32403 1 p.

Research output: Contribution to journal › Comment/debate

2 Citations (Scopus)

Differences in the outcomes of adjuvant chemotherapy for colon cancer prescribed by physicians in different disciplines: A population-based study in Taiwan

Hsieh, C. I., Kuo, R. N. C., Liang, C. C., Tsai, H. Y. & Chung, K. P., Dec 1 2018, In : BMJ Open. 8, 12, 021341.

Research output: Contribution to journal › Article

Open Access

Inhibition of aqueous extracts of Solanum nigrum (AESN) on oral cancer through regulation of mitochondrial fission

Uen, W. C., Lee, B. H., Shi, Y. C., Wu, S. C., Tai, C. J. & Tai, C. J., 2018, In : Journal of Traditional and Complementary Medicine.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water

Wang, C-K., Chen, H-C., Fang, S-U., Ho, C-W., Tai, C-J., Yang, C-P. & Liu, Y-C., Dec 1 2018, In : Scientific Reports. 8, 1, p. 6316 6316.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Intensity-modulated radiotherapy with systemic chemotherapy improves survival in patients with nonmetastatic unresectable pancreatic adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study

Lin, Y. K., Hsieh, M. C., Chang, C. L., Chow, J. M., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., Nov 1 2018, In : Radiotherapy and Oncology. 129, 2, p. 326-332 7 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Maspin enhances the anticancer activity of curcumin in hormone-refractory prostate cancer cells

Cheng, W. L., Huang, C. Y., Tai, C. J., Chang, Y. J. & Hung, C. S., Feb 1 2018, In : Anticancer Research. 38, 2, p. 863-870 8 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells

Kao, R. H., Lai, G. M., Chow, J. M., Liao, C. H., Zheng, Y. M., Tsai, W. L., Hsia, S., Lai, I. C., Lee, H. L., Chuang, S. E., Whang-Peng, J. & Yao, C. J., Oct 8 2018, In : Nutrients. 10, 10, 1458.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells

Wang, S. W., Chen, Y. R., Chow, J. M., Chien, M. H., Yang, S. F., Wen, Y. C., Lee, W. J. & Tseng, T. H., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Symptom severity, symptom interference and use of complementary and alternative medicine among survivors of colorectal and breast cancer after curative treatment in Taiwan

Wu, H. J., Tai, C. J., Tai, C. J. & Chien, L. Y., Jan 1 2018, (Accepted/In press) In : European Journal of Cancer Care. e12925.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Type 1 diabetes mellitus with diabetic ketoacidosis after immune checkpoint inhibitor therapy

Chuang, P. Y., Chao, T-Y. & Hsieh, Y-Y., Dec 2018, In : Journal of Cancer Research and Practice. p. 153-155

Research output: Contribution to journal › Article

2017

Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

Lai, I. C., Lai, G. M., Chow, J. M., Lee, H. L., Yeh, C. F., Li, C. H., Yan, J. L., Chuang, S. E., Whang-Peng, J., Bai, K. J. & Yao, C. J., Nov 15 2017, In : Chinese Medicine (United Kingdom). 12, 1, 33.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts

Tai, C. J., Wang, H., Wang, C. K., Tai, C. J., Huang, M. T., Wu, C. H., Chen, R. J., Kuo, L. J., Wei, P. L., Chang, Y. J., Chang, C. C., Chiou, H. Y. & Wu, C. J., May 1 2017, In : Clinical and Experimental Medicine. 17, 2, p. 141-150 10 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Cancer-related pain: A nationwide survey of patients' treatment modification and satisfaction in Taiwan

Rau, K. M., Chen, J. S., Wu, H. B., Lin, S. F., Huang, M. L., Tai, C. J., Hwang, W. L., Lu, Y. C., Wang, C. C. & Hsieh, R. K., Jan 1 2017, In : Japanese Journal of Clinical Oncology. 47, 11, p. 1060-1065 6 p.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Corrigendum: Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y. C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L-M., Feb 22 2017, In : Scientific Reports. 7, 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Corrigendum to “RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin” [J. Funct. Foods (2015) 19PA (236–247)] (S1756464615004478)(10.1016/j.jff.2015.09.030)

Lin, C-W., Lai, G-M., Chen, K-C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C-M., Lin, C-M., Kandaswami, C. C., Lee, M. T. & Cheng, C-H., Feb 1 2017, In : Journal of Functional Foods. 29, p. 303 1 p.

Research output: Contribution to journal › Comment/debate

Cyproheptadine use in hepatocellular carcinoma

Hsieh, M. C., Lee, W. H., Wu, A. T. H., Chow, J. M., Chang, C. L., Yuan, K. S. P. & Wu, S. Y., 2017, In : American Journal of Cancer Research. 7, 3, p. 584-602 19 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells

Wu, C. Y., Cherng, J. Y., Yang, Y. H., Lin, C. L., Kuan, F. C., Lin, Y. Y., Lin, Y. S., Shu, L. H., Cheng, Y. C., Liu, H. T., Lu, M. C., Lung, J., Chen, P. C., Lin, H. K., Lee, K. D. & Tsai, Y. H., 2017, In : Oncotarget. 8, 53, p. 90925-90947 23 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma

Chang, C. L., Tsai, H. C., Lin, W. C., Chang, J. H., Hsu, H. L., Chow, J. M., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., 2017, (Accepted/In press) In : Radiotherapy and Oncology.

Research output: Contribution to journal › Article

30 Citations (Scopus)

Effectiveness of esophagectomy in patients with thoracic esophageal squamous cell carcinoma receiving definitive radiotherapy or concurrent chemoradiotherapy through intensity-modulated radiation therapy techniques

Yen, Y-C., Chang, J. H., Lin, W. C., Chiou, J. F., Chang, Y. C., Chang, C. L., Hsu, H. L., Chow, J. M., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journal › Article

22 Citations (Scopus)

Highly bioavailable silibinin nanoparticles inhibit HCV infection

Liu, C. H., Lin, C. C., Hsu, W. C., Chung, C. Y., Lin, C. C., Jassey, A., Chang, S. P., Tai, C. J., Tai, C. J., Shields, J., Richardson, C. D., Yen, M. H., Tyrrell, D. L. J. & Lin, L. T., Oct 2017, In : Gut. 66, 10, p. 1853-1861

Research output: Contribution to journal › Article

13 Citations (Scopus)

JAK2V617F influences epigenomic changes in myeloproliferative neoplasms

Chen, C. C., Chiu, C. C., Lee, K. D., Hsu, C. C., Chen, H. C., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., Dec 16 2017, In : Biochemical and Biophysical Research Communications. 494, 3-4, p. 470-476 7 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Quercetin simultaneously induces G0/G1-phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells

Chang, J. L., Chow, J. M., Chang, J. H., Wen, Y-C., Lin, Y. W., Yang, S. F., Lee, W. J. & Chien, M. H., 2017, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

Kao, S. J., Lee, W. J., Chang, J. H., Chow, J. M., Chung, C. L., Hung, W. Y. & Chien, M. H., Apr 1 2017, In : Environmental Toxicology. 32, 4, p. 1426-1438

Research output: Contribution to journal › Article

25 Citations (Scopus)

Terminally Ill Taiwanese Cancer Patients’ and Family Caregivers’ Agreement on Patterns of Life-Sustaining Treatment Preferences Is Poor to Fair and Declines Over a Decade: Results From Two Independent Cross-Sectional Studies

Liu, T. W., Wen, F. H., Wang, C. H., Hong, R. L., Chow, J. M., Chen, J. S., Chiu, C. F. & Tang, S. T., Jul 1 2017, In : Journal of Pain and Symptom Management. 54, 1, p. 35-45.e4

Research output: Contribution to journal › Article

8 Citations (Scopus)

The bidirectional association between oral cancer and esophageal cancer: A population-based study in Taiwan over a 28-year period

Lee, K. D., Wang, T. Y., Lu, C. H., Huang, C. E. & Chen, M. C., 2017, In : Oncotarget. 8, 27, p. 44567-44578 12 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Tricetin induces apoptosis of human leukemic HL-60 cells through a reactive oxygen species-mediated c-jun N-terminal kinase activation pathway

Chien, M. H., Chow, J. M., Lee, W. J., Chen, H. Y., Tan, P., Wen, Y. C., Lin, Y. W., Hsiao, P. C. & Yang, S. F., Aug 1 2017, In : International Journal of Molecular Sciences. 18, 8, 1667.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Chien, M. H., Lee, T. H., Lee, W. J., Yeh, Y. H., Li, T. K., Wang, P. C., Chen, J. J., Chow, J. M., Lin, Y. W., Hsiao, M., Wang, S. W. & Hua, K. T., Mar 1 2017, In : Cancer Letters. 388, p. 249-261 13 p.

Research output: Contribution to journal › Article

6 Citations (Scopus)
2016

Activation of p53/miR-34a tumor suppressor axis by Chinese herbal formula JP-1 in A549 lung adenocarcinoma cells

Yao, C. J., Chow, J. M., Lin, P. C., Hu, T. S., Kuo, H. C., Huang, J. S., Bai, K. J. & Lai, G. M., 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 5989681.

Research output: Contribution to journal › Article

4 Citations (Scopus)