Department of Pharmacology

  • No. 250 Wu-Xing Street

    11031 Taipei

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2020

Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis striata BBRR1

Boopathy, A. B., Jayakumar, T., Chinnasamy, S., Rajaram, M. G., Mohan, N., Nagaraj, S., Rengasamy, R., Manubolu, M., Sheu, J. R. & Chang, C. C., Jan 1 2020, In : Energies. 13, 2, 341.

Research output: Contribution to journalArticle

Open Access

Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain

Yang, C. H., Di Antonio, A., Kirschen, G. W., Varma, P., Hsieh, J. & Ge, S., Jan 28 2020, In : Cell Reports. 30, 4, p. 959-968.e3

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

CK1δ as a potential therapeutic target to treat bladder cancer

Lin, Y. C., Chen, M. C., Hsieh, T. H., Liou, J. P. & Chen, C. H., Apr 15 2020, In : Aging. 12, 7, p. 5764-5780 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Label-free multi-microfluidic immunoassays with liquid crystals on polydimethylsiloxane biosensing chips

Fan, Y. J., Chen, F. L., Liou, J. C., Huang, Y. W., Chen, C. H., Hong, Z. Y., Lin, J. D. & Hsiao, Y. C., Feb 1 2020, In : Polymers. 12, 2, 395.

Research output: Contribution to journalArticle

Open Access

Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade

Huang, S. W., Chyuan, I. T., Shiue, C., Yu, M. C., Hsu, Y. F. & Hsu, M. J., Jan 1 2020, In : Journal of Cellular and Molecular Medicine. 24, 2, p. 1822-1836 15 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: Regulation by integrin αiIbβ3 inside-out but not outside-in signals

Hou, S. M., Hsia, C. W., Tsai, C. L., Hsia, C. H., Jayakumar, T., Velusamy, M. & Sheu, J. R., May 6 2020, In : Journal of Biomedical Science. 27, 1, 60.

Research output: Contribution to journalArticle

Open Access

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-κB signaling and free radical production

Jayakumar, T., Huang, H. C., Hsia, C. W., Fong, T. H., Khamrang, T., Velusamy, M., Manubolu, M., Sheu, J. R. & Hsia, C. H., Mar 2020, In : Bioorganic Chemistry. 96, 103639.

Research output: Contribution to journalArticle

2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling

Lien, J. C., Chung, C. L., Huang, T. F., Chang, T. C., Chen, K. C., Gao, G. Y., Hsu, M. J. & Huang, S. W., Oct 1 2019, In : British Journal of Pharmacology. 176, 20, p. 4034-4049 16 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2 Citations (Scopus)

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y., Lu, W. J. & Lin, K. H., Oct 18 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions

Wu, Z-H., Tsai, J-H., Hsieh, C-Y., Chen, W-L. & Chung, C-L., Mar 29 2019, In : Journal of Clinical Medicine. 8, 4, 426.

Research output: Contribution to journalArticle

Esculetin, A coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2-PKC-AKT activation in human platelets

Hsia, C. W., Lin, K. C., Lee, T. Y., Hsia, C. H., Chou, D. S., Jayakumar, T., Velusamy, M. & Sheu, J. R., Jun 1 2019, In : International Journal of Molecular Sciences. 20, 11, 2731.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

2 Citations (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In : Marine Drugs. 17, 6, 360.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Intravenous thrombolysis administration 3–4.5 h after acute ischemic stroke: A retrospective, multicenter study

Chen, Y. W., Sung, S. F., Chen, C. H., Tang, S. C., Tsai, L. K., Lin, H. J., Huang, H. Y., Po, H. L., Sun, Y., Chen, P. L., Chan, L., Wei, C. Y., Lee, J. T., Hsieh, C. Y., Lin, Y. Y., Yeh, S. J., Lien, L. M. & Jeng, J. S., Jan 1 2019, In : Frontiers in Neurology. 10, OCT, 1038.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 11 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
2 Citations (Scopus)

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Protective effects of ammannia baccifera against ccl4-induced oxidative stress in rats

Goodla, L., Manubolu, M., Pathakoti, K., Jayakumar, T., Sheu, J. R., Fraker, M., Tchounwou, P. B. & Poondamalli, P. R., Apr 2 2019, In : International Journal of Environmental Research and Public Health. 16, 8, 1440.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Suppression of human platelet activation via integrin αiibβ3 outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene

Hsia, C. W., Tsai, C. L., Sheu, J. R., Lu, W. J., Hsia, C. H., Velusamy, M., Jayakumar, T. & Li, J. Y., Nov 2 2019, In : International Journal of Molecular Sciences. 20, 22, 5585.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
Open Access
2 Citations (Scopus)

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

Lu, W. J., Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y. & Lin, K. H., Dec 1 2019, In : Scientific Reports. 9, 1, 18852.

Research output: Contribution to journalArticle

Open Access

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

Huang, S. W., Yang, H. Y., Huang, W. J., Chen, W. C., Yu, M. C., Wang, S. W., Hsu, Y. F. & Hsu, M. J., Nov 6 2019, In : Frontiers in Oncology. 9, 1188.

Research output: Contribution to journalArticle

Open Access
2018

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., Nov 18 2018, In : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., Mar 1 2018, In : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., Jun 1 2018, In : Energies. 11, 6, en11061341.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Decreased risk of pneumonia in stroke patients receiving acupuncture: A nationwide matched-pair retrospective cohort study

Chang, C. C., Chen, T. L., Lin, C. S., Chung, C. L., Yeh, C. C., Hu, C. J., Lane, H. L., Liao, C. C. & Shih, C. C., May 1 2018, In : PLoS One. 13, 5, e0196094.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
6 Citations (Scopus)

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells

Lee, Y. L., Hsiao, C. J., Lin, F. L., Jan, J. S., Chou, Y. C., Lin, Y. Y., Chen, C. K., Lam, K. K. & Hsiao, G., Jan 1 2018, In : Mediators of Inflammation. 2018, 1 p., 9541459.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., Mar 22 2018, In : International Journal of Molecular Sciences. 19, 4, 939.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53

Li, J-Y., Liu, C-P., Shiao, W-C., Jayakumar, T., Li, Y-S., Chang, N-C., Huang, S-Y. & Hsieh, C-Y., Jan 1 2018, In : Archives of Medical Science. 14, 3, p. 579-587 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice

Huang, S. W., Lien, J. C., Kuo, S. C. & Huang, T. F., Jan 1 2018, In : Thrombosis and Haemostasis. 118, 2, p. 401-414 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation

Shyu, R. S., Khamrang, T., Sheu, J. R., Hsia, C. W., Velusamy, M., Hsia, C. H., Chou, D. S. & Chang, C. C., Jan 1 2018, In : Bioinorganic Chemistry and Applications. 2018, p. 8291393 8291393.

Research output: Contribution to journalArticle

2 Citations (Scopus)
4 Citations (Scopus)

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., Aug 1 2018, In : Food and Function. 9, 8, p. 4500-4507 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions

Lee, K. L., Chen, W. L., Chen, R. J., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology. 23, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Lupus pneumonitis presenting with high titre of anti-ro antibody

Chen, M. C., Wu, Y. L., Lee, K. L., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology Case Reports. 6, 1, e00280.

Research output: Contribution to journalArticle

Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study

Wang, C. L., Yang, P. S., Tsao, J. T., Jayakumar, T., Wang, M. J., Sheu, J. R. & Chou, D. S., Jan 1 2018, In : Molecular Medicine Reports. 17, 1, p. 2061-2069 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)