Department of Pediatrics

Projects

Projects per year 2010 2012 2013 2014 2016 2017 2018 2019 2020 2021 2022

• 5 Active
• 71 Finished

Projects per year

Search results

• Active

  探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析：以雙面向方法發展對抗沙門氏菌感染之新策略(3/3)

  Fang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以CRISPR/Cas9基因編輯平台發展MYC/BCL2/BCL6作為人類B細胞淋巴癌標靶精準治療模式

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣家族特有肌聯蛋白單?酸位點變異導致肌失養症之病因學研究 (II)

  Kuo, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 後生元和益生菌透過抑制炎症和調節免疫力減輕新生小鼠高氧誘導的肺損傷

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗Tn單株抗體透過抑制氧化應激和炎症反應減輕新生仔鼠高氧誘導的腎臟損傷

  Chen, C.

  3/1/21 → 2/28/22

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Finished

  應用循環腫瘤細胞預測標靶藥物對復發性、難治性、高危險群兒科腫瘤的治療反應

  Liu, Y.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 人工智慧輔助發展抗藥性非傷寒沙門氏菌之創新型診斷工具及探討沙門氏菌與定植和抗生素反應相關之基因

  Fang, S.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 以體外循環腫瘤細胞擴增系統發展兒童神經腫瘤精準醫療策略

  Liu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析：以雙面向方法發展對抗沙門氏菌感染之新策略(2/3)

  Fang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高氧誘導的肺損傷由新生小鼠的肺和腸道微生物群相介導

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣家族特有肌聯蛋白單酶酸位點變異導致肌失養症之病因學研究

  Kuo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 周產期尼古丁暴露對小鼠後代肺發育的影響

  Chen, C.

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › n - Yuan's General Hospital

• 探討胸腺基質淋巴生成素接受器在氣喘兒童白血球免疫表型的表現

  Lin, S.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 應用循環腫瘤細胞預測標靶藥物對復發性、難治性、高危險群兒科腫瘤的治療反應

  Liu, Y.

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Artificial intelligence-assisted development of innovative diagnostics for antibiotic-resistant non-typhoidal Salmonella and investigation of Salmonella genes associated with colonization and antibiotic response

  Fang, S.

  1/1/20 → 12/31/20

  Project: A - Government Institution › d - Ministry of Education

• The Impact of Chromatin-Modifying Agents on the Tumor Differentiation and Mibg Uptake of Neuroblastoma

  Liu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Effects and Mechanisms of Tn Immunization on Hyperoxia-Induced Lung Injury in Neonatal Rats(2/2)

  Chen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Precision Medicine 100%
  • Leukemia 88%
  • Heterografts 41%
  • Philadelphia Chromosome 39%
  • Myeloid Leukemia 37%

• Characterization of YqiC for developing targeted antibiotics and genetic analysis of Salmonella antibiotic resistance and invasiveness: a two-way approach to novel strategies against salmonellosis (1/3)

  Fang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cathelicidin通過抑制氧化應激減輕新生仔鼠高氧誘導的肺損傷

  Chen, C.

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• Developing novel strategies for combating antibiotic-resistant Salmonella. Subproject: Identification of inhibitors for intracellular ceftriaxone-resistant Salmonella as novel antibiotics and whole transcriptome RNA sequencing for global gene regulation by yqiC in Salmonella

  Fang, S.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 氣喘兒童胸腺基質淋巴生成素接受器在周邊血球免疫表型的監測

  Lin, S.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• Investigation of Effects and Mechanisms of Tn Immunization on Hyperoxia-Induced Lung Injury in Neonatal Rats

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Severity Model of Brain Damage: Examining the Blood-Brain Early Injurious and Protective Biomarker Panels That Relate to the Susceptibility and Tolerance Responses of Hypoxic Ischemia(II)(2/3)

  Huang, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Restoration of Mitochondrial Function: in Search of Therapeutic Agents for Metabolic Myopathy

  Kuo, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Muscular Diseases 100%
  • Organelle Biogenesis 52%
  • Electric Stimulation 37%
  • Nutrients 35%
  • Smegmamorpha 31%

• Molecular Biomarkers Targeting the Metastatic Relapse of Neuroblastoma

  Liu, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neuroblastoma 100%
  • Biomarkers 65%
  • Residual Neoplasm 17%
  • Neoplasm Metastasis 10%
  • Molecular Imaging 9%

• Investigation of novel genetic mutations for antibiotic resistance, intracellular upregulated Salmonella genes within host cells, and the mechanisms of yqiC-induced host innate immunity for combating Salmonella infection (3/3)

  Fang, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Salmonella 100%
  • antibiotic resistance 37%
  • ciprofloxacin 34%
  • point mutation 33%
  • genes 26%

• 新聘教師研究補助

  Kuo, Y.

  1/1/18 → 12/31/18

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 發展迎戰抗生素抗藥性沙門氏桿菌的新策略

  Fang, S.

  1/1/18 → 12/31/18

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Construction and Application of Medical Image Database in Tmu Healthcare System( I )

  Huang, C.

  11/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Liu, Y.

  10/1/17 → 9/30/18

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Lin, S.

  10/1/17 → 9/30/18

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Molecular Biomarkers Targeting the Metastatic Relapse of Neuroblastoma

  Liu, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neuroblastoma 100%
  • Biomarkers 65%
  • Residual Neoplasm 17%
  • Neoplasm Metastasis 10%
  • Molecular Imaging 9%

• Investigation of novel genetic mutations for antibiotic resistance, intracellular upregulated Salmonella genes within host cells, and the mechanisms of yqiC-induced host innate immunity for combating Salmonella infection (2/3)

  Fang, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Salmonella 100%
  • antibiotic resistance 37%
  • ciprofloxacin 34%
  • point mutation 33%
  • genes 26%

• The Role of Tripartite Motif Protein 72 in the Regulation of Irs and Pi3k/Akt/Mtor Pathway in Experimental Bronchopulmonary Dysplasia: in Vitro and in Vivo Assessment

  Huang, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hyperoxia 100%
  • Bronchopulmonary Dysplasia 77%
  • TOR Serine-Threonine Kinases 69%
  • Insulin Receptor Substrate Proteins 69%
  • Phosphatidylinositol 3-Kinase 54%

• The Severity Model of Brain Damage: Examining the Blood-Brain Early Injurious and Protective Biomarker Panels That Relate to the Susceptibility and Tolerance Responses of Hypoxic Ischemia( I )

  Huang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immunization with Tn Antigen Protects Adult Mice and Newborn Rats against Hyperoxia-Induced Lung Injury via Inhibition of Nuclear Factor-Κb Signaling Pathway

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hyperoxia 100%
  • Lung Injury 54%
  • Tn antigen 28%
  • Bronchopulmonary Dysplasia 28%
  • Immunization 24%

• The Molecular Basis, Preventive Efficacy of Angiotension II Receptor Blockade and Quality of Life in Marfan Syndrome

  Chiu, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Marfan Syndrome 100%
  • Fibrillin-1 35%
  • Losartan 28%
  • Dilatation 19%
  • Quality of Life 15%

• 新聘教師研究補助

  Wang, J.

  4/1/17 → 3/31/18

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Huang, L.

  1/1/17 → 12/31/17

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring(3/3)

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• The Molecular Basis, Preventive Efficacy of Angiotension II Receptor Blockade and Quality of Life in Marfan Syndrome

  Chiu, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Marfan Syndrome 100%
  • Fibrillin-1 35%
  • Losartan 28%
  • Dilatation 19%
  • Quality of Life 15%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain(3/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• The Role of Cysteine Cathepsins in Suppressing the Peroxisome Proliferator-Activated Receptor R (Pparr) Co-Activator 1a (Pgc-1a) Expression in the Process of Skeletal Muscle Atrophy and Development of Preclinical Therapeutics Model

  Kuo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cathepsins 100%
  • Muscular Atrophy 85%
  • Skeletal Muscle 67%
  • Cathepsin L 59%
  • Cysteine 40%

• Investigation of Novel Genetic Mutations for Antibiotic Resistance, Intracellularly Upregulated Salmonella Genes Within Host Cells, and the Mechanisms of Yqic-Induced Host Innate Immunity for Combating Salmonella Infection

  Fang, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Salmonella 100%
  • antibiotic resistance 37%
  • ciprofloxacin 34%
  • point mutation 33%
  • genes 26%

• 母體幼年期睡眠剝奪對子代代謝功能之影響

  Chiu, H.

  6/1/16 → 5/31/17

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 新聘教師研究補助

  Chiu, H.

  4/1/16 → 7/19/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

  Fang, S. & Huang, M.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Salmonella 100%
  • Virulence 62%
  • Salmonella Infections 59%
  • Salmonella typhimurium 54%
  • Genes 47%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

  Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%