Department of General Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

2009
76 Citations (Scopus)

In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

Wu, C. H., Ho, Y. S., Tsai, C. Y., Wang, Y. J., Tseng, H., Wei, P. L., Lee, C. H., Liu, R. S. & Lin, S. Y., May 1 2009, In : International Journal of Cancer. 124, 9, p. 2210-2219 10 p.

Research output: Contribution to journalArticle

Phloretin
Facilitative Glucose Transport Proteins
Liver Neoplasms
Apoptosis
Hep G2 Cells
20 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Cytokines
Ligands
Tumor Necrosis Factor-alpha
coenzyme Q10
20 Citations (Scopus)

Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network

Chung, T. W., Lin, S. Y., Liu, D. Z., Tyan, Y. C. & Yang, J. S., Dec 1 2009, In : International Journal of Pharmaceutics. 382, 1-2, p. 39-44 6 p.

Research output: Contribution to journalArticle

Poloxamer
Chitosan
Fluorouracil
Gels
Glutaral
59 Citations (Scopus)
Nicotinic Receptors
Carcinogens
Colonic Neoplasms
Tobacco
Cell Movement
2008
86 Citations (Scopus)
Phyllanthus urinaria
Phyllanthus
Amine Oxidase (Copper-Containing)
antihypertensive effect
amines
21 Citations (Scopus)

Antioxidant and nitric oxide production inhibitory activities of galacturonyl hydroxamic acid

Liu, Y. H., Lin, S. Y., Lee, C. C. & Hou, W. C., Jul 1 2008, In : Food Chemistry. 109, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

hydroxamic acids
Hydroxamic Acids
galacturonic acid
nitric oxide
Nitric Oxide
1 Citation (Scopus)

Assessment of user satisfaction with an internet-based integrated patient education system for diabetes management

Yeh, Y. T., Liu, C. T., Wu, S. J. & Lee, T. I., 2008, 2008 10th IEEE Intl. Conf. on e-Health Networking, Applications and Service, HEALTHCOM 2008. p. 85-89 5 p. 4600116

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Patient Education
Medical problems
Internet
Education
Patient Satisfaction
144 Citations (Scopus)

Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes

Yu, W. L., Ko, W. C., Cheng, K-C., Lee, C. C., Lai, C-C. & Chuang, Y. C., Sep 2008, In : Diagnostic Microbiology and Infectious Disease. 62, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Liver Abscess
Klebsiella pneumoniae
Virulence Factors
Phenotype
Virulence
5 Citations (Scopus)

Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Uen, Y. H., Wang, Y. J., Hsu, T. M., Chen, M. H., Chan, H. Y., Ho, Y. S. & Lin, S. Y., Sep 2008, In : Journal of Bioactive and Compatible Polymers. 23, 5, p. 458-472 15 p.

Research output: Contribution to journalArticle

Chitosan
Fluorouracil
Molecular Weight
Molecular weight
Bearings (structural)
Hydroxamic Acids
Nitric Oxide
Antioxidants
19 Citations (Scopus)

Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Chen, C. H., Liu, D. Z., Fang, H. W., Liang, H. J., Yang, T. S. & Lin, S. Y., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 6, p. 1586-1594 9 p.

Research output: Contribution to journalArticle

stomach neoplasms
Liposomes
octreotide
drug therapy
Stomach Neoplasms
39 Citations (Scopus)

Liposome encapsulation reduces cantharidin toxicity

Chang, C. C., Liu, D. Z., Lin, S. Y., Liang, H. J., Hou, W. C., Huang, W. J., Chang, C. H., Ho, F. M. & Liang, Y. C., Sep 2008, In : Food and Chemical Toxicology. 46, 9, p. 3116-3121 6 p.

Research output: Contribution to journalArticle

Cantharidin
cantharidin
encapsulation
Encapsulation
Liposomes
19 Citations (Scopus)
Osmotic Pressure
Drug Delivery Systems
Tablets
Rupture
Membranes

Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling

Cheng, Y. W., Chang, C. Y., Lin, K. L., Hu, C. M., Lin, C. H. & Kang, J. J., Nov 20 2008, In : Journal of Ethnopharmacology. 120, 2, p. 264-71 8 p.

Research output: Contribution to journalArticle

NF-kappa B
Lipopolysaccharides
Down-Regulation
Lithospermum
Naphthoquinones
9 Citations (Scopus)

Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats

Suk, F. M., Lin, S. Y., Chen, C. H., Yen, S. J., Su, C. H., Liu, D. Z., Hou, W. C., Hung, L. F., Lin, P. J. & Liang, Y. C., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 7, p. 1704-1713 10 p.

Research output: Contribution to journalArticle

Taiwanofungus camphoratus
Peroxisome Proliferator-Activated Receptors
PPAR gamma
Rats
fruiting bodies
2007
46 Citations (Scopus)
Taiwanofungus camphoratus
antihypertensive effect
Inbred SHR Rats
Antihypertensive Agents
Methanol
23 Citations (Scopus)

Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis

Lin, S. Y., Chan, H. Y., Shen, F. H., Chen, M. H., Wang, Y. J. & Yu, C. K., Apr 15 2007, In : Journal of Cellular Biochemistry. 100, 6, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Chitosan
Cell Proliferation
Molecular Weight
Molecular weight
71 Citations (Scopus)

Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action

Liu, D. Z., Liang, H. J., Chen, C. H., Su, C. H., Li, Z-H., Huang, C. T., Hou, W. C., Lin, S. Y., Zhong, W-B., Lin, P. J., Hung, L. F. & Liang, Y. C., Aug 15 2007, In : Journal of Ethnopharmacology. 113, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Microglia
Fermentation
Methanol
Anti-Inflammatory Agents
Neurodegenerative Diseases
42 Citations (Scopus)
Patient Education
Blood Glucose
Fasting
Control Groups
Education
5 Citations (Scopus)
Taiwanofungus camphoratus
Amine Oxidase (Copper-Containing)
Scavenging
amines
biphenyl
22 Citations (Scopus)

NF-κB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells

Uen, Y. H., Liu, D. Z., Weng, M. S., Ho, Y. S. & Lin, S. Y., Aug 1 2007, In : Journal of Cellular Biochemistry. 101, 5, p. 1165-1175 11 p.

Research output: Contribution to journalArticle

Griseofulvin
HL-60 Cells
Apoptosis
Tosylphenylalanyl Chloromethyl Ketone
G2 Phase Cell Cycle Checkpoints
4 Citations (Scopus)

Silent myocardial ischemia in coronary artery disease patients under aspirin therapy presenting with upper gastrointestinal hemorrhage

Chen, C. C., Chong, C. F., Kuo, C. D. & Wang, Z-L., 2007, In : Journal of Gastroenterology and Hepatology (Australia). 22, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

Gastrointestinal Hemorrhage
Aspirin
Myocardial Ischemia
Coronary Artery Disease
Length of Stay
27 Citations (Scopus)
Dextromethorphan
Plasma (human)
Metabolites
Dextrorphan
High Pressure Liquid Chromatography
12 Citations (Scopus)

Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin

Liu, D. Z., Liang, H. J., Chen, C. H., Lin, S. Y., Zhong, W-B., Ho, F. M., Hou, W. C., Lo, J. L., Ho, Y. S., Lin, P. J., Hung, L. F. & Liang, Y. C., Jun 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 6, p. 869-879 11 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Phosphatidylinositol 3-Kinase
Macrophages
Plasmids
Phosphatidylinositol 4,5-Diphosphate
2006
1 Citation (Scopus)

Chronic bifascicular block with intermittent complete atrioventricular block induced by hyperthyroidism

Kuo, Y. C., Tseng, Y. T., Lee, T. I. & Hsieh, M. H., Jun 28 2006, In : International Journal of Cardiology. 110, 3, p. 407-410 4 p.

Research output: Contribution to journalArticle

Atrioventricular Node
Atrioventricular Block
Hyperthyroidism
Heart Diseases
Electrocardiography
9 Citations (Scopus)

Development and evaluation of an integrated patient-oriented education management system for diabetes

Yeh, Y-T., Chiu, Y. T., Liu, C-T., Wu, S. J. & Lee, T-I., 2006, Studies in Health Technology and Informatics. Vol. 122. p. 172-175 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Patient Education
Medical problems
Education
Glucose
Self Care
33 Citations (Scopus)
Dioscorea alata
Dioscorea
yams
Blood pressure
Inbred SHR Rats
20 Citations (Scopus)

Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

Lin, T. J., Liao, L. Y., Lin, S. Y., Lin, C. L. & Chang, T. A., Aug 14 2006, In : World Journal of Gastroenterology. 12, 30, p. 4897-4901 5 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Fibrosis
Iron
Liver
Serum
8 Citations (Scopus)

Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells

Yang, K-C., Wu, C-C., Wu, C-H., Chen, J. H., Chu, C. H., Chen, C-H., Chou, Y. H., Wang, Y. J., Lee, W-S., Tseng, H., Lin, S-Y., Lee, C-H. & Ho, Y-S., Feb 2006, In : Food and Chemical Toxicology. 44, 2, p. 214-226 13 p.

Research output: Contribution to journalArticle

terbinafine
HL-60 Cells
apoptosis
Apoptosis
Mitochondria
30 Citations (Scopus)

Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells

Wang, C. C., Lin, S. Y., Cheng, H. C. & Hou, W. C., Aug 2006, In : Food and Chemical Toxicology. 44, 8, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

HL-60 Cells
oxidants
Reactive Oxygen Species
Cytotoxicity
superoxide dismutase
23 Citations (Scopus)

Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes

Tsai, Y. C., Chou, Y. C., Wu, A-B., Hu, C-M., Chen, C. Y., Chen, F. A. & Lee, J. A., Feb 16 2006, In : Life Sciences. 78, 12, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
Cardiac Myocytes
Rats
Glucose
Ketone Bodies
2005
20 Citations (Scopus)

Antioxidant activities of mucilages from different Taiwanese yam cultivars

Lin, S. Y., Liu, H. Y., Lu, Y. L. & Hou, W. C., Jul 2005, In : Botanical Bulletin of Academia Sinica. 46, 3, p. 183-188 6 p.

Research output: Contribution to journalArticle

mucilages
yams
antioxidant activity
cultivars
hydroxyl radicals
74 Citations (Scopus)

Balthazar computed tomography severity index is superior to Ranson criteria and APACHE II scoring system in predicting acute pancreatitis outcome

Leung, T-K., Lee, C-M., Lin, S. Y., Chen, H. C., Wang, H. J., Shen, L. K. & Chen, Y. Y., Oct 14 2005, In : World Journal of Gastroenterology. 11, 38, p. 6049-6052 4 p.

Research output: Contribution to journalArticle

APACHE
Pancreatitis
Tomography
Spiral Computed Tomography
Hospitalization
3 Citations (Scopus)

Elevated nitric oxide levels inhibit malondialdehyde production in patients with diabetes mellitus in Taiwan [2]

Lee, T. I., Sun, M. F., Wen, Y. R., Kuo, P. L. & Liu, C. F., Dec 2005, In : Nutrition, Metabolism and Cardiovascular Diseases. 15, 6, p. 452-453 2 p.

Research output: Contribution to journalArticle

Malondialdehyde
Type 1 Diabetes Mellitus
Taiwan
Type 2 Diabetes Mellitus
Case-Control Studies
27 Citations (Scopus)

Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase

Liang, Y. C., Wu, C. H., Chu, J. S., Wang, C. K., Hung, L. F., Wang, Y. J., Ho, Y. S., Chang, J. G. & Lin, S. Y., May 7 2005, In : World Journal of Gastroenterology. 11, 17, p. 2557-2563 7 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Coenzyme A
Ligases
Cyclic AMP
Hepatocellular Carcinoma
24 Citations (Scopus)

Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

Yang, K-C., Uen, Y. H., Suk, F. M., Liang, Y. C., Wang, Y. J., Ho, Y. S., Li, I. H. & Lin, S. Y., May 28 2005, In : World Journal of Gastroenterology. 11, 20, p. 3040-3045 6 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Carcinogenesis
Apoptosis Inducing Factor
Apoptosis
Caspase 8
30 Citations (Scopus)
Econazole
G1 Phase Cell Cycle Checkpoints
caspase-8
Caspase 8
colorectal neoplasms
15 Citations (Scopus)

Observations on online services for diabetes management [3]

Liu, C. T., Yeh, Y. T., Lee, T. I. & Li, Y. C., 2005, In : Diabetes Care. 28, 11, p. 2807-2808 2 p.

Research output: Contribution to journalArticle

Computer-Assisted Instruction
User-Computer Interface
Blood Glucose Self-Monitoring
Cell Phones
Patient Education
68 Citations (Scopus)
Succinic Acid
Surface-Active Agents
Polysorbates
Pharmaceutical Preparations
Proteins
10 Citations (Scopus)

Somatostatin analogue mimics acute ischemic preconditioning in a rat model of myocardial infarction

Wang, Z-L., Huang, Y. H. & Chang, H., Apr 2005, In : Journal of Cardiovascular Pharmacology. 45, 4, p. 327-332 6 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Octreotide
Somatostatin
Myocardial Infarction
KATP Channels
22 Citations (Scopus)

The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1

Chou, Y. H., Ho, F. M., Liu, D. Z., Lin, S. Y., Tsai, L-H., Chen, C. H., Ho, Y. S., Hung, L. F. & Liang, Y. C., Mar 2005, In : International Journal of Biochemistry and Cell Biology. 37, 3, p. 604-615 12 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Shock
Hot Temperature
Gene expression
Gene Expression

結合醫院就醫資訊之糖尿病衛生教育網際網路系統之返診成效評估

Translated title of the contribution: Evaluation on Return Rates of Follow-ups for An Integrated Diabetes Patient-Centered Education SystemLiu, C-T., Yeh, Y-T., Lee, T-I., Hsu, C-Y. & Li, Y-C., 2005, In : 醫療資訊雜誌. 14, 2, p. 17-25 9 p.

Research output: Contribution to journalArticle

Medical problems
Education
Electronic mail
Websites
Internet

結合醫院臨床照護與衛生教育網際網路服務系統-以糖尿病為例

Translated title of the contribution: A framework for integrating information of clinical care into patient education for diabetesYeh, Y-T., Lee, T-I., Hsu, C-Y., Long, A-J., Li, Y-C. & Liu, C-T., 2005, In : 醫療資訊雜誌. 14, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Medical problems
Education
Information systems
Internet
2004
14 Citations (Scopus)

Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells

Shih, C. R., Wu, J., Liu, Y., Liang, Y. C., Lin, S. Y., Sheu, M. T. & Lee, W. S., Jan 1 2004, In : Biochemical Pharmacology. 67, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Endothelial Cells
Phosphotransferases
Thymidine
18 Citations (Scopus)

Primary hypothalamic lymphoma with panhypopituitarism presenting as Stiff-man syndrome

Lee, M. T., Lee, T. I., Won, J. G. S., Chau, W. K., Yang, H. J., Li, J. C., Lin, H. D. & Tang, K. T., Aug 2004, In : American Journal of the Medical Sciences. 328, 2, p. 124-128 5 p.

Research output: Contribution to journalArticle

Stiff-Person Syndrome
Lymphoma
Myalgia
Thyroxine
Hydrocortisone
32 Citations (Scopus)

Promoter CpG methylation caveolin-1 in sporadic colorectal cancer

Lin, S. Y., Yeh, K. T., Chen, W. T. L., Chen, H. C., Chen, S. T. & Chang, J. G., May 2004, In : Anticancer Research. 24, 3 A, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Caveolin 1
Methylation
Colorectal Neoplasms
Genes
Gene Silencing
39 Citations (Scopus)

Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features

Lin, S. Y., Yeh, K. T., Chen, W. T. L., Chen, H. C., Chen, S. T., Chiou, H. Y. & Chang, J. G., Feb 2004, In : Oncology Reports. 11, 2, p. 341-348 8 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Methylation
Colorectal Neoplasms
Glycogen Synthase Kinase 3
Cadherins
27 Citations (Scopus)

Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-Δ 12,14-prostaglandin J2-induced heme oxygenase-1 expression

Liu, J-D., Tsai, S. H., Lin, S. Y., Ho, Y. S., Hung, L. F., Pan, S., Ho, F. M., Lin, C. M. & Liang, Y. C., Mar 26 2004, In : Life Sciences. 74, 19, p. 2451-2463 13 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Reducing Agents
Sulfhydryl Compounds
Antioxidants
Dithiothreitol
2003
2 Citations (Scopus)

A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of cushing's syndrome: A comparison with the standard high-dose dexamethasone suppression test

Lee, T. I. T. I., Lin, S. Y., Won, J. G. S., Tang, K. T., Jap, T. S., Kwok, C. F. & Lin, H. D., Jan 1 2003, In : Chinese Medical Journal (Taipei). 65, 10, p. 474-482 9 p.

Research output: Contribution to journalArticle

Cushing Syndrome
Corticotropin-Releasing Hormone
Dexamethasone
Sheep
Differential Diagnosis
14 Citations (Scopus)

Inflammatory Pseudotumor Resulting from Foreign Body in Abdominal Cavity Detected by FDG PET

Hsu, C-H., Lee, C-M. & Lin, S-Y., Oct 2003, In : Clinical Nuclear Medicine. 28, 10, p. 842-844 3 p.

Research output: Contribution to journalArticle

Plasma Cell Granuloma
Abdominal Cavity
Foreign Bodies
Abdomen
Body Image