Department of General Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

2015
11 Citations (Scopus)

Potential of vitamin D in treating diabetic cardiomyopathy

Lee, T. W., Lee, T. I., Chang, C. J., Lien, G. S., Kao, Y. H., Chao, T. F. & Chen, Y. J., Apr 1 2015, In : Nutrition Research. 35, 4, p. 269-279 11 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Vitamin D
Diabetes Mellitus
Cardiovascular Diseases
Hyperphosphatemia
2 Citations (Scopus)

Surface-enhanced Raman scattering on a silver film-modified Au nanoparticle-decorated SiO2 mask array

Chang, C. C., Chen, L. Y., Yang, K. H., Chen, Q. Y., Liang, Y. C., Lin, S. Y. & Liu, Y. C., Jul 23 2015, In : RSC Advances. 5, 81, p. 66096-66103 8 p.

Research output: Contribution to journalArticle

Silver
Raman scattering
Masks
Nanoparticles
Calcium
46 Citations (Scopus)

The influence of diabetes, glycemic control, and diabetes-related comorbidities on pulmonary tuberculosis

Chiang, C. Y., Bai, K. J., Lin, H. H., Chien, S. T., Lee, J. J., Enarson, D. A., Lee, T. I. & Yu, M. C., Mar 30 2015, In : PLoS One. 10, 3, e0121698.

Research output: Contribution to journalArticle

glycemic control
Medical problems
Pulmonary Tuberculosis
tuberculosis
diabetes
3 Citations (Scopus)

Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice

Lin, S. Y., Huang, G. C., Hsieh, Y. Y., Lin, Y. S., Han, C. H., Wen, C. L., Chang, C. I. & Hou, W. C., Oct 28 2015, In : Journal of Agricultural and Food Chemistry. 63, 42, p. 9286-9294 9 p.

Research output: Contribution to journalArticle

Obese Mice
Vitis
High Fat Diet
high fat diet
Nutrition
2014
19 Citations (Scopus)
Dioscorea
dipeptides
Dipeptides
yams
Computer Simulation
18 Citations (Scopus)

Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells

Jayakumar, T., Chang, C. C., Lin, S. L., Huang, Y. K., Hu, C. M., Elizebeth, A. R., Lin, S. C. & Choy, C-S., 2014, In : BioMed Research International. 2014, 403703.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Computer aided manufacturing
Blood Vessels
Inflammation
32 Citations (Scopus)
Calcitriol Receptors
Calcitriol
Tissue Inhibitor of Metalloproteinase-2
Procollagen
Angiotensin Type 1 Receptor
14 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Calcitriol
Diabetes Mellitus
Inflammation
Fatty Acids
6 Citations (Scopus)

Effect of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents

Hsiao, F. C., Lin, Y. F., Hsieh, P. S., Chu, N. F., Chen, Y. D. I., Shieh, Y. S., Hsieh, C. H., Lee, C. H., Lee, T. I. & Hung, Y. J., 2014, In : International Journal of Endocrinology. 2014, 674069.

Research output: Contribution to journalArticle

Adiposity
Insulin Resistance
Inflammation
Genotype
Genes
20 Citations (Scopus)
Dioscorea
yams
Galactose
galactose
tubers
24 Citations (Scopus)

Empowering village doctors and enhancing rural healthcare using cloud computing in a rural area of mainland China

Lin, C-W., Abdul, S. S., Clinciu, D. L., Scholl, J., Jin, X., Lu, H., Chen, S. S., Iqbal, U., Heineck, M. J. & Li, Y. C., Feb 2014, In : Computer Methods and Programs in Biomedicine. 113, 2, p. 585-592 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Cloud computing
China
Preventive Medicine
Health
29 Citations (Scopus)

MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses

Lin, R-J., Chu, J. S., Chien, H. L., Tseng, C. H., Ko, P. C., Mei, Y. Y., Tang, W. C., Kao, Y. T., Cheng, H. Y., Liang, Y. C. & Lin, S. Y., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4159-4168 10 p.

Research output: Contribution to journalArticle

Virus Replication
Hepacivirus
Cytokines
Viruses
Virus Diseases
12 Citations (Scopus)
Cell Movement
Transforming Growth Factors
Adenocarcinoma
Derivatives
Phosphorylation
5 Citations (Scopus)
Polygonum
Thoracic Aorta
Vasodilation
Nitric Oxide Synthase
Endothelial Cells
42 Citations (Scopus)

Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication

Tang, W. C., Lin, R. J., Liao, C. L. & Lin, Y. L., 2014, In : Journal of Virology. 88, 12, p. 6793-6804 12 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Dengue virus
fatty-acid synthase
Dengue Virus
Virus Diseases
1 Citation (Scopus)

Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium

Chang, C. J., Yang, T. F., Lee, T. I., Chen, Y. C., Kao, Y. H., Chen, S. A. & Chen, Y. J., 2014, In : Acta Cardiologica Sinica. 30, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Pulmonary Veins
Inbred WKY Rats
Inbred SHR Rats
Heart Atria
pamidronate
18 Citations (Scopus)

Testosterone replacement increases aged pulmonary vein and left atrium arrhythmogenesis with enhanced adrenergic activity

Tsai, W. C., Lee, T-I., Chen, Y. C., Kao, Y-H., Lu, Y. Y., Lin, Y-K., Chen, S. A. & Chen, Y-J., 2014, In : International Journal of Cardiology. 176, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

Pulmonary Veins
Heart Atria
Adrenergic Agents
Testosterone
Rabbits
2013
17 Citations (Scopus)

15,16-dihydrotanshinone i-induced apoptosis in human colorectal cancer cells: Involvement of ATF3

Suk, F. M., Jou, W. J., Lin, R-J., Lin, S. Y., Tzeng, F. Y. & Liang, Y. C., Aug 2013, In : Anticancer Research. 33, 8, p. 3225-3232 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Apoptosis
Activating Transcription Factor 3
Salvia miltiorrhiza
Medicinal Plants
3 Citations (Scopus)
Feasibility Studies
examination
university
methodology
Students
7 Citations (Scopus)

Characteristics of patients with Clostridium difficile infection in Taiwan

Lin, Y. C., Huang, Y. T., Lee, T. F., Lee, N. Y., Liao, C. H., Lin, S. Y., Ko, W. C. & Hsueh, P. R., Oct 2013, In : Epidemiology and Infection. 141, 10, p. 2031-2038 8 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Taiwan
Genes
Mortality
11 Citations (Scopus)

Cytotoxicity of (-)-vitisin B in human leukemia cells

Wu, S. S., Chen, L. G., Lin, R-J., Lin, S. Y., Lo, Y. E. & Liang, Y. C., Jul 2013, In : Drug and Chemical Toxicology. 36, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

Resveratrol
Cell death
Cytotoxicity
Leukemia
Cell proliferation
6 Citations (Scopus)

Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women

Hsiao, F. C., Hsieh, C. H., Wu, C. Z., Hsu, C. H., Lin, J. D., Lee, T. I., Pei, D. & Chen, Y. L., Jul 2013, In : European Journal of Internal Medicine. 24, 5, p. 425-429 5 p.

Research output: Contribution to journalArticle

Fasting
Reference Values
Glucose
Blood Pressure
Dyslipidemias
5 Downloads (Pure)
File
Epidermal Growth Factor Receptor
Lung Neoplasms
Smoking
Mutation
Adenocarcinoma
60 Citations (Scopus)

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

Lin, R-J., Chien, H. L., Lin, S. Y., Chang, B. L., Yu, H. P., Tang, W. C. & Lin, Y. L., Mar 2013, In : Nucleic Acids Research. 41, 5, p. 3314-3326 13 p.

Research output: Contribution to journalArticle

Chemokine CCL2
RNA Stability
Viral RNA
Ribonucleases
Antiviral Agents
9 Citations (Scopus)
Cytotoxicity
Colon
Adenocarcinoma
Derivatives
Phosphorylation
33 Citations (Scopus)

Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy

Lee, T. I., Kao, Y. H., Chen, Y. C., Huang, J. H., Hsiao, F. C. & Chen, Y. J., Jun 2013, In : Diabetes Research and Clinical Practice. 100, 3, p. 330-339 10 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Peroxisome Proliferator-Activated Receptors
Diabetes Mellitus
Homeostasis
Inflammation
9 Citations (Scopus)

Pheochromocytoma mimicking both acute coronary syndrome and sepsis: A case report

Lee, T. W., Lin, K. H., Chang, C. J., Lew, W. H. & Lee, T. I., Jun 2013, In : Medical Principles and Practice. 22, 4, p. 405-407 3 p.

Research output: Contribution to journalArticle

Pheochromocytoma
Acute Coronary Syndrome
Sepsis
Glandular and Epithelial Neoplasms
Adrenalectomy
13 Citations (Scopus)

Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway

Cheng, H. W., Lee, K. C., Cheah, K. P., Chang, M. L., Lin, C-W., Li, J. S., Yu, W. Y., Liu, E. T. & Hu, C. M., Feb 2013, In : Journal of the Science of Food and Agriculture. 93, 3, p. 491-497 7 p.

Research output: Contribution to journalArticle

Bistorta vivipara
NF-E2-Related Factor 2
Polygonum
Heme Oxygenase (Decyclizing)
oxygenases
21 Citations (Scopus)

Postoperative adverse outcomes after non-hepatic surgery in patients with liver cirrhosis

Lin, C-S., Lin, S-Y., Chang, C-C., Wang, H. H., Liao, C-C. & Chen, T-L., Dec 2013, In : British Journal of Surgery. 100, 13, p. 1784-1790 7 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Odds Ratio
Mortality
Fibrosis
Confidence Intervals
18 Citations (Scopus)

Rosiglitazone induces arrhythmogenesis in diabetic hypertensive rats with calcium handling alteration

Lee, T. I., Chen, Y. C., Kao, Y. H., Hsiao, F. C., Lin, Y. K. & Chen, Y. J., May 10 2013, In : International Journal of Cardiology. 165, 2, p. 299-307 9 p.

Research output: Contribution to journalArticle

rosiglitazone
Inbred SHR Rats
Calcium
Hypertension
Ryanodine Receptor Calcium Release Channel
25 Citations (Scopus)
Dipeptidyl-Peptidase IV Inhibitors
Peroxisome Proliferator-Activated Receptors
Cardiac Myocytes
Inbred SHR Rats
Inflammation
2012
19 Citations (Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., Jun 15 2012, In : Food Chemistry. 132, 4, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Niacin
niacin
catechol oxidase
Antioxidants
10 Citations (Scopus)

Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers

Liu, C. P., Chen, W. C., Lai, K. H., Mar, G. Y., Lin, S. Y., Ger, L. P. & Hsu, P. I., Jul 2012, In : American Journal of Gastroenterology. 107, 7, p. 1022-1029 8 p.

Research output: Contribution to journalArticle

Esomeprazole
Peptic Ulcer
Aspirin
Ulcer
Confidence Intervals
30 Citations (Scopus)

Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-jB/p53 pathway mediated by folic acid receptor

Lin, S. Y., Lee, W. R., Su, Y. F., Hsu, S. P., Lin, H. C., Ho, P. Y., Hou, T. C., Chou, Y. P., Kuo, C. T. & Lee, W. S., 2012, In : Angiogenesis. 15, 4, p. 671-683 13 p.

Research output: Contribution to journalArticle

Endothelial cells
Cell proliferation
Folic Acid
Endothelial Cells
Cell Proliferation
1 Citation (Scopus)

Research update for articles published in EJCI in 2010

Adlbrecht, C., Aigner, E., Bellón, J. M., Bouloukaki, I., Bouzas-Mosquera, A., Carrilho, A. J. F., Chang, K. C., Chattipakorn, N., Chattipakorn, S. C., Chen, Y. J., Chung, Y. C., Colah, R., Datz, C., Frøkjær, J. B., Fujimori, S., Georgiadou, P., Grion, C. M., Hsu, C. P., Hülsmann, M., Hung, M. J. & 16 others, Hung, M. Y., Iliodromitis, E. K., Lang, I. M., Lee, T. I., März, W., Nair, S. B., Pascual, G., Peteiro, J., Sakamoto, C., Satomura, A., Schiza, S. E., Stärkel, P., Stojakovic, T., Vesely, D. L., Walters, D. L. & Yilmaz, Y., Nov 2012, In : European Journal of Clinical Investigation. 42, 11, p. 1149-1164 16 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The antinociceptive and anti-inflammatory activities of Petasites formosanus Kitamura extract

Lin, S. Y., Teng, H. L., Tseng, S. H., Chen, L. G. & Wang, C. C., Oct 2012, In : Botanical Studies. 53, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

Petasites
anti-inflammatory activity
leaf extracts
carrageenan
edema
2011
20 Citations (Scopus)
Salvia miltiorrhiza
Prostate
Apoptosis
Carcinoma
Transcription Factor CHOP
37 Citations (Scopus)

Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in Taiwan

Lin, Y. C., Huang, Y. T., Tsai, P. J., Lee, T. F., Lee, N. Y., Liao, C. H., Lin, S. Y., Ko, W. C. & Hsueh, P. R., Apr 2011, In : Antimicrobial Agents and Chemotherapy. 55, 4, p. 1701-1705 5 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Clostridium difficile
Taiwan
Ribotyping
Polymerase Chain Reaction
5 Citations (Scopus)
Colorectal Neoplasms
Epidemiology
Smoking
Microsatellite Instability
Neoplasms

Concurrence of classic type Ehlers-Danlos syndrome and moderate hemophilia A in a Taiwanese: a case report

Chang, C-Y., Tsai, C-H., Tsai, J-R., Yeh, G-C., Lin, S-Y. & Tseng, I. J., Jul 31 2011, In : Journal of Thrombosis and Haemostasis. 9, s2, p. 475 1 p., P-TU-530.

Research output: Contribution to journalMeeting Abstract

rosiglitazone
PPAR gamma
Diabetes Mellitus
Atrioventricular Block
Hypertension
25 Citations (Scopus)

Hydralazine-induced promoter demethylation enhances sarcoplasmic reticulum Ca2+-ATPase and calcium homeostasis in cardiac myocytes

Kao, Y. H., Cheng, C. C., Chen, Y. C., Chung, C. C., Lee, T. I., Chen, S. A. & Chen, Y. J., Sep 2011, In : Laboratory Investigation. 91, 9, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

Hydralazine
Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Cardiac Myocytes
Homeostasis
34 Citations (Scopus)

Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells

Lee, W. H., Lin, R-J., Lin, S. Y., Chen, Y. C., Lin, H. M. & Liang, Y. C., Dec 28 2011, In : Journal of Agricultural and Food Chemistry. 59, 24, p. 12874-12881 8 p.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
myocytes
Muscle Cells
Muscle
9 Citations (Scopus)
Nicotinic Receptors
Nicotine
Breast Neoplasms
Neoplasm Metastasis
Cell Movement
2010
16 Citations (Scopus)

Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo

Wang, C. K., Chen, L. G., Wen, C. L., Hou, W. C., Hung, L. F., Yen, S. J., Shen, Y. J., Lin, S. Y. & Liang, Y. C., Feb 1 2010, In : Journal of Medicinal Food. 13, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Vitis
Hydrogen Peroxide
Ethanol
Kainic Acid
Nitric Oxide
28 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Oxidative stress
Oxidative Stress
Inflammation
Medical problems
4 Citations (Scopus)

Subcapsular renal hematoma complicating acute pyelonephritis

You, C. F., Chong, C. F., Wang, Z-L. & Chen, C. C., Oct 2010, In : Journal of Emergency Medicine. 39, 4, p. 440-442 3 p.

Research output: Contribution to journalArticle

Pyelonephritis
Hematoma
Kidney
59 Citations (Scopus)

Tumor necrosis factor-α decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes

Kao, Y. H., Chen, Y. C., Cheng, C. C., Lee, T. I., Chen, Y. J. & Chen, S. A., Jan 2010, In : Critical Care Medicine. 38, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Cardiac Myocytes
Methylation
Tumor Necrosis Factor-alpha
2009
15 Citations (Scopus)

15-Deoxy-Δ12,14-prostaglandin J2 inhibits fibrogenic response in human hepatoma cells

Suk, F. M., Chen, C. H., Lin, S. Y., Cheng, C. J., Yen, S. J., Hung, L. F., Liu, D. Z. & Liang, Y. C., May 22 2009, In : Toxicology Letters. 187, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Peroxisome Proliferator-Activated Receptors
Connective Tissue Growth Factor
Hepatocellular Carcinoma
Phosphorylation
14 Citations (Scopus)

Feeding trial of instant food containing lyophilised yam powder in hypertensive subjects

Liu, D. Z., Liang, H. J., Han, C. H., Lin, S. Y., Chen, C. T., Fan, M. & Hou, W. C., Jan 15 2009, In : Journal of the Science of Food and Agriculture. 89, 1, p. 138-143 6 p.

Research output: Contribution to journalArticle

instant foods
Dioscorea
yams
Powders
placebos