Department of General Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

Article
22 Citations (Scopus)
Dioscorea
yams
Galactose
galactose
tubers
6 Citations (Scopus)

Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women

Hsiao, F. C., Hsieh, C. H., Wu, C. Z., Hsu, C. H., Lin, J. D., Lee, T. I., Pei, D. & Chen, Y. L., Jul 2013, In : European Journal of Internal Medicine. 24, 5, p. 425-429 5 p.

Research output: Contribution to journalArticle

Fasting
Reference Values
Glucose
Blood Pressure
Dyslipidemias
3 Citations (Scopus)

Elevated nitric oxide levels inhibit malondialdehyde production in patients with diabetes mellitus in Taiwan [2]

Lee, T. I., Sun, M. F., Wen, Y. R., Kuo, P. L. & Liu, C. F., Dec 2005, In : Nutrition, Metabolism and Cardiovascular Diseases. 15, 6, p. 452-453 2 p.

Research output: Contribution to journalArticle

Malondialdehyde
Type 1 Diabetes Mellitus
Taiwan
Type 2 Diabetes Mellitus
Case-Control Studies
2 Citations (Scopus)
Open Access
diabetes mellitus
Streptozocin
Medical problems
rats
Rats
24 Citations (Scopus)

Empowering village doctors and enhancing rural healthcare using cloud computing in a rural area of mainland China

Lin, C-W., Abdul, S. S., Clinciu, D. L., Scholl, J., Jin, X., Lu, H., Chen, S. S., Iqbal, U., Heineck, M. J. & Li, Y. C., Feb 2014, In : Computer Methods and Programs in Biomedicine. 113, 2, p. 585-592 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Cloud computing
China
Preventive Medicine
Health
Hydroxamic Acids
Nitric Oxide
Antioxidants
10 Citations (Scopus)

Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers

Liu, C. P., Chen, W. C., Lai, K. H., Mar, G. Y., Lin, S. Y., Ger, L. P. & Hsu, P. I., Jul 2012, In : American Journal of Gastroenterology. 107, 7, p. 1022-1029 8 p.

Research output: Contribution to journalArticle

Esomeprazole
Peptic Ulcer
Aspirin
Ulcer
Confidence Intervals
19 Citations (Scopus)

Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Chen, C. H., Liu, D. Z., Fang, H. W., Liang, H. J., Yang, T. S. & Lin, S. Y., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 6, p. 1586-1594 9 p.

Research output: Contribution to journalArticle

stomach neoplasms
Liposomes
octreotide
drug therapy
Stomach Neoplasms
14 Citations (Scopus)

Feeding trial of instant food containing lyophilised yam powder in hypertensive subjects

Liu, D. Z., Liang, H. J., Han, C. H., Lin, S. Y., Chen, C. T., Fan, M. & Hou, W. C., Jan 15 2009, In : Journal of the Science of Food and Agriculture. 89, 1, p. 138-143 6 p.

Research output: Contribution to journalArticle

instant foods
Dioscorea
yams
Powders
placebos
8 Citations (Scopus)
Pulmonary Veins
Cardiac Myocytes
Fibroblast Growth Factor 1
Homeostasis
Sodium
30 Citations (Scopus)

Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-jB/p53 pathway mediated by folic acid receptor

Lin, S. Y., Lee, W. R., Su, Y. F., Hsu, S. P., Lin, H. C., Ho, P. Y., Hou, T. C., Chou, Y. P., Kuo, C. T. & Lee, W. S., 2012, In : Angiogenesis. 15, 4, p. 671-683 13 p.

Research output: Contribution to journalArticle

Endothelial cells
Cell proliferation
Folic Acid
Endothelial Cells
Cell Proliferation
9 Citations (Scopus)

Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes

Huang, J. H., Chen, Y. C., Lee, T. I., Kao, Y. H., Chazo, T. F., Chen, S. A. & Chen, Y. J., Apr 1 2016, In : Peptides. 78, p. 91-98 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Cardiac Myocytes
Homeostasis
Calcium
Ryanodine Receptor Calcium Release Channel
4 Citations (Scopus)

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Lin, Y. S., Wu, W. C., Lin, S. Y. & Hou, W. C., 2015, In : Amino Acids. 47, 3, p. 617-625 9 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Melanins
Glycine
Down-Regulation
Agaricales
14 Citations (Scopus)

HDAC inhibition modulates cardiac PPARs and fatty acid metabolism in diabetic cardiomyopathy

Lee, T. I., Kao, Y. H., Tsai, W. C., Chung, C. C., Chen, Y. C. & Chen, Y. J., 2016, In : PPAR Research. 2016, 5938740.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Peroxisome Proliferator-Activated Receptors
Histone Deacetylases
Diabetes Mellitus
Fatty Acids
20 Citations (Scopus)

High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Simon-Loriere, E., Lin, R-J., Kalayanarooj, S. M., Chuansumrit, A., Casademont, I., Lin, S. Y., Yu, H. P., Lert-Itthiporn, W., Chaiyaratana, W., Tangthawornchaikul, N., Tangnararatchakit, K., Vasanawathana, S., Chang, B. L., Suriyaphol, P., Yoksan, S., Malasit, P., Despres, P., Paul, R., Lin, Y. L. & Sakuntabhai, A., 2015, In : Journal of Infectious Diseases. 212, 12, p. 2011-2020 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Genes
Virus Diseases
Antiviral Agents
5 Downloads (Pure)
File
Epidermal Growth Factor Receptor
Lung Neoplasms
Smoking
Mutation
Adenocarcinoma
2 Citations (Scopus)
Histone Deacetylases
Autophagy
High Fat Diet
Nutrition
Streptozocin
2 Citations (Scopus)

Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice

Lu, Y. L., Lin, S. Y., Fang, S. U., Hsieh, Y. Y., Chen, C. R., Wen, C. L., Chang, C. I. & Hou, W. C., Mar 29 2017, In : Journal of Agricultural and Food Chemistry. 65, 12, p. 2521-2529 9 p.

Research output: Contribution to journalArticle

viniferins
Vitis
High Fat Diet
high fat diet
Nutrition
25 Citations (Scopus)

Hydralazine-induced promoter demethylation enhances sarcoplasmic reticulum Ca2+-ATPase and calcium homeostasis in cardiac myocytes

Kao, Y. H., Cheng, C. C., Chen, Y. C., Chung, C. C., Lee, T. I., Chen, S. A. & Chen, Y. J., Sep 2011, In : Laboratory Investigation. 91, 9, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

Hydralazine
Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Cardiac Myocytes
Homeostasis

Iatrogenic tracheal rupture after emergent intubation

Chou, C. L., Lee, T. I. & Hu, T. Y., 2016, (Accepted/In press) In : Archivos de Bronconeumologia.

Research output: Contribution to journalArticle

Intubation
Rupture
18 Citations (Scopus)
Critical Care
Methicillin-Resistant Staphylococcus aureus
Intensive Care Units
Costs and Cost Analysis
Mortality
9 Citations (Scopus)

Increased risk of hepatocellular carcinoma in chronic hepatitis C patients with new onset diabetes: A nation-wide cohort study

Huang, Y. W., Wang, T. C., Yang, S. S., Lin, S. Y., Fu, S. C., Hu, J. T., Liu, C. J., Kao, J. H. & Chen, D. S., Oct 1 2015, In : Alimentary Pharmacology and Therapeutics. 42, 7, p. 902-911 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Hepatocellular Carcinoma
Cohort Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mortality
14 Citations (Scopus)

Inflammatory Pseudotumor Resulting from Foreign Body in Abdominal Cavity Detected by FDG PET

Hsu, C-H., Lee, C-M. & Lin, S-Y., Oct 2003, In : Clinical Nuclear Medicine. 28, 10, p. 842-844 3 p.

Research output: Contribution to journalArticle

Plasma Cell Granuloma
Abdominal Cavity
Foreign Bodies
Abdomen
Body Image
20 Citations (Scopus)

Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

Lin, T. J., Liao, L. Y., Lin, S. Y., Lin, C. L. & Chang, T. A., Aug 14 2006, In : World Journal of Gastroenterology. 12, 30, p. 4897-4901 5 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Fibrosis
Iron
Liver
Serum
53 Citations (Scopus)

In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest

Lee, W. S., Chen, R. J., Wang, Y. J., Tseng, H., Jeng, J. H., Lin, S. Y., Liang, Y. C., Chen, C. H., Lin, C. H., Lin, J. K., Ho, P. Y., Chu, J. S., Ho, W. L., Chen, L. C. & Ho, Y. S., Aug 10 2003, In : International Journal of Cancer. 106, 1, p. 125-137 13 p.

Research output: Contribution to journalArticle

terbinafine
Cell Cycle Checkpoints
Cell Line
Neoplasms
In Vitro Techniques
76 Citations (Scopus)

In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

Wu, C. H., Ho, Y. S., Tsai, C. Y., Wang, Y. J., Tseng, H., Wei, P. L., Lee, C. H., Liu, R. S. & Lin, S. Y., May 1 2009, In : International Journal of Cancer. 124, 9, p. 2210-2219 10 p.

Research output: Contribution to journalArticle

Phloretin
Facilitative Glucose Transport Proteins
Liver Neoplasms
Apoptosis
Hep G2 Cells
36 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Colonic Neoplasms
Up-Regulation
30 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Stomach
Epithelial Cells
Phosphotransferases
Apoptosis
27 Citations (Scopus)

Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase

Liang, Y. C., Wu, C. H., Chu, J. S., Wang, C. K., Hung, L. F., Wang, Y. J., Ho, Y. S., Chang, J. G. & Lin, S. Y., May 7 2005, In : World Journal of Gastroenterology. 11, 17, p. 2557-2563 7 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Coenzyme A
Ligases
Cyclic AMP
Hepatocellular Carcinoma
8 Citations (Scopus)

Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells

Yang, K-C., Wu, C-C., Wu, C-H., Chen, J. H., Chu, C. H., Chen, C-H., Chou, Y. H., Wang, Y. J., Lee, W-S., Tseng, H., Lin, S-Y., Lee, C-H. & Ho, Y-S., Feb 2006, In : Food and Chemical Toxicology. 44, 2, p. 214-226 13 p.

Research output: Contribution to journalArticle

terbinafine
HL-60 Cells
apoptosis
Apoptosis
Mitochondria
10 Citations (Scopus)

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation

Kao, Y. T., Chang, B. L., Liang, J. J., Tsai, H. J., Lee, Y. L., Lin, R. J. & Lin, Y. L., Mar 1 2015, In : PLoS Pathogens. 11, 3, p. 1-26 26 p., e1004750.

Research output: Contribution to journalArticle

Mitochondrial Trifunctional Protein
Japanese Encephalitis Virus
Fatty Acids
Proteins
Cytokines
22 Citations (Scopus)

Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity

Wang, Y. J., Yu, C. F., Chen, L. C., Chen, C. H., Lin, J. K., Liang, Y. C., Lin, C. H., Lin, S. Y., Chen, C. F. & Ho, Y. S., 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Terfenadine
Cytochrome P-450 CYP3A
Ketoconazole
Hep G2 Cells
Apoptosis
39 Citations (Scopus)

Liposome encapsulation reduces cantharidin toxicity

Chang, C. C., Liu, D. Z., Lin, S. Y., Liang, H. J., Hou, W. C., Huang, W. J., Chang, C. H., Ho, F. M. & Liang, Y. C., Sep 2008, In : Food and Chemical Toxicology. 46, 9, p. 3116-3121 6 p.

Research output: Contribution to journalArticle

Cantharidin
cantharidin
encapsulation
Encapsulation
Liposomes
98 Citations (Scopus)
Liver Neoplasms
Liver
Colonic Neoplasms
Cells
Apoptosis
5 Citations (Scopus)

Managing mass events and competitions with difficult-to-access locations using mobile electrocardiac monitoring

Shih, C-M., Lin, C-W., Clinciu, D. L., Jian, W-S., Kuo, T. B. J., Nguyen, P. A., Usman, I., Hsu, C. K., Owili, P. O. & Li, Y-C., Apr 13 2015, (Accepted/In press) In : Computer Methods and Programs in Biomedicine. 121, 2, p. 109-115

Research output: Contribution to journalArticle

Wireless Technology
Emergencies
Monitoring
Cardiac Arrhythmias
Electrocardiography
60 Citations (Scopus)

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

Lin, R-J., Chien, H. L., Lin, S. Y., Chang, B. L., Yu, H. P., Tang, W. C. & Lin, Y. L., Mar 2013, In : Nucleic Acids Research. 41, 5, p. 3314-3326 13 p.

Research output: Contribution to journalArticle

Chemokine CCL2
RNA Stability
Viral RNA
Ribonucleases
Antiviral Agents
29 Citations (Scopus)

MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses

Lin, R-J., Chu, J. S., Chien, H. L., Tseng, C. H., Ko, P. C., Mei, Y. Y., Tang, W. C., Kao, Y. T., Cheng, H. Y., Liang, Y. C. & Lin, S. Y., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4159-4168 10 p.

Research output: Contribution to journalArticle

Virus Replication
Hepacivirus
Cytokines
Viruses
Virus Diseases
1 Citation (Scopus)

MCPIP3 as a potential metastasis suppressor gene in human colorectal cancer

Suk, F. M., Chang, C. C., Lin, R. J., Lin, S. Y., Chen, Y. T. & Liang, Y. C., May 3 2018, In : International Journal of Molecular Sciences. 19, 5, 1350.

Research output: Contribution to journalArticle

Monocyte Chemoattractant Proteins
monocytes
suppressors
metastasis
Tumor Suppressor Genes
4 Citations (Scopus)

Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease

Chang, W. H., Niu, D. M., Lu, C. Y., Lin, S. Y., Liu, T. C. & Chang, J. G., Apr 1 2017, In : PLoS One. 12, 4, e0175929.

Research output: Contribution to journalArticle

Fabry Disease
Amiloride
alternative splicing
Alternative Splicing
Histone Code
69 Citations (Scopus)

Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells

Lin, S. Y., Chang, Y. T., Liu, J-D., Yu, C. H., Ho, Y. S., Lee, Y-H. & Lee, W. S., 2001, In : Molecular Carcinogenesis. 32, 2, p. 73-83 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Colonic Neoplasms
Caspase 8
Apoptosis
Caspase 9
24 Citations (Scopus)

Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

Yang, K-C., Uen, Y. H., Suk, F. M., Liang, Y. C., Wang, Y. J., Ho, Y. S., Li, I. H. & Lin, S. Y., May 28 2005, In : World Journal of Gastroenterology. 11, 20, p. 3040-3045 6 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Carcinogenesis
Apoptosis Inducing Factor
Apoptosis
Caspase 8
30 Citations (Scopus)
Econazole
G1 Phase Cell Cycle Checkpoints
caspase-8
Caspase 8
colorectal neoplasms

MSH2 and MLH1 Expression in Sporadic Colorectal Cancer

Lin, S-Y., Wang, C. K., Pan, S., Chen, Y-J. & Liu, J-D., Jun 2000, In : New Taipei Journal of Medicine. 2, 2, p. 109-113 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Multiple truncated transcripts of TSG101 in gastrointestinal cancers

Lin, S. Y., Chen, Y. J. & Chang, J. G., 1998, In : Journal of Gastroenterology and Hepatology (Australia). 13, 11, p. 1111-1114 4 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Stomach
Esophageal Neoplasms
Tumor Suppressor Genes
Reverse Transcriptase Polymerase Chain Reaction
16 Citations (Scopus)

Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo

Wang, C. K., Chen, L. G., Wen, C. L., Hou, W. C., Hung, L. F., Yen, S. J., Shen, Y. J., Lin, S. Y. & Liang, Y. C., Feb 1 2010, In : Journal of Medicinal Food. 13, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Vitis
Hydrogen Peroxide
Ethanol
Kainic Acid
Nitric Oxide
22 Citations (Scopus)

NF-κB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells

Uen, Y. H., Liu, D. Z., Weng, M. S., Ho, Y. S. & Lin, S. Y., Aug 1 2007, In : Journal of Cellular Biochemistry. 101, 5, p. 1165-1175 11 p.

Research output: Contribution to journalArticle

Griseofulvin
HL-60 Cells
Apoptosis
Tosylphenylalanyl Chloromethyl Ketone
G2 Phase Cell Cycle Checkpoints
7 Citations (Scopus)

N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK

Lee, W. H., Wu, H. H., Huang, W. J., Li, Y. N., Lin, R-J., Lin, S. Y. & Liang, Y. C., Mar 1 2015, In : Molecules. 20, 3, p. 4516-4529 14 p.

Research output: Contribution to journalArticle

hyperglycemia
AMP-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
glucose
Hyperglycemia
12 Citations (Scopus)
Cell Movement
Transforming Growth Factors
Adenocarcinoma
Derivatives
Phosphorylation
9 Citations (Scopus)
Cytotoxicity
Colon
Adenocarcinoma
Derivatives
Phosphorylation