Department of General Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

Article
Dioscorea
Glucose Intolerance
dipeptides
Dipeptides
yams
20 Citations (Scopus)
Salvia miltiorrhiza
Prostate
Apoptosis
Carcinoma
Transcription Factor CHOP
17 Citations (Scopus)

15,16-dihydrotanshinone i-induced apoptosis in human colorectal cancer cells: Involvement of ATF3

Suk, F. M., Jou, W. J., Lin, R-J., Lin, S. Y., Tzeng, F. Y. & Liang, Y. C., Aug 2013, In : Anticancer Research. 33, 8, p. 3225-3232 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Apoptosis
Activating Transcription Factor 3
Salvia miltiorrhiza
Medicinal Plants
15 Citations (Scopus)

15-Deoxy-Δ12,14-prostaglandin J2 inhibits fibrogenic response in human hepatoma cells

Suk, F. M., Chen, C. H., Lin, S. Y., Cheng, C. J., Yen, S. J., Hung, L. F., Liu, D. Z. & Liang, Y. C., May 22 2009, In : Toxicology Letters. 187, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Peroxisome Proliferator-Activated Receptors
Connective Tissue Growth Factor
Hepatocellular Carcinoma
Phosphorylation
3 Citations (Scopus)

Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

Lkhagva, B., Kao, Y. H., Lee, T. I., Lee, T. W., Cheng, W. L. & Chen, Y. J., May 1 2018, (Accepted/In press) In : Epigenetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cardiac Myocytes
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
Enzymes
5 Citations (Scopus)

ADAM10 modulates calcitriol-regulated RAGE in cardiomyocytes

Lee, T. W., Kao, Y. H., Lee, T. I. & Chen, Y. J., Sep 1 2017, In : European Journal of Clinical Investigation. 47, 9, p. 675-683 9 p.

Research output: Contribution to journalArticle

Disintegrins
Calcitriol Receptors
Calcitriol
Metalloproteases
Cardiac Myocytes

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology.

Research output: Contribution to journalArticle

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis
3 Citations (Scopus)

Analysis of aberrant transcription of TSG101 in hepatocellular carcinomas

Chen, Y. J., Chen, P. H., Lin, S. Y. & Chang, J. G., Feb 1999, In : European Journal of Cancer. 35, 2, p. 302-308 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Genes
Chromosomes
Choristoma
Cell Line
3 Citations (Scopus)
Feasibility Studies
examination
university
methodology
Students
46 Citations (Scopus)
Taiwanofungus camphoratus
antihypertensive effect
Inbred SHR Rats
Antihypertensive Agents
Methanol
37 Citations (Scopus)

Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in Taiwan

Lin, Y. C., Huang, Y. T., Tsai, P. J., Lee, T. F., Lee, N. Y., Liao, C. H., Lin, S. Y., Ko, W. C. & Hsueh, P. R., Apr 2011, In : Antimicrobial Agents and Chemotherapy. 55, 4, p. 1701-1705 5 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Clostridium difficile
Taiwan
Ribotyping
Polymerase Chain Reaction
86 Citations (Scopus)
Phyllanthus urinaria
Phyllanthus
Amine Oxidase (Copper-Containing)
antihypertensive effect
amines
20 Citations (Scopus)

Antioxidant activities of mucilages from different Taiwanese yam cultivars

Lin, S. Y., Liu, H. Y., Lu, Y. L. & Hou, W. C., Jul 2005, In : Botanical Bulletin of Academia Sinica. 46, 3, p. 183-188 6 p.

Research output: Contribution to journalArticle

mucilages
yams
antioxidant activity
cultivars
hydroxyl radicals
19 Citations (Scopus)
Dioscorea
dipeptides
Dipeptides
yams
Computer Simulation
21 Citations (Scopus)

Antioxidant and nitric oxide production inhibitory activities of galacturonyl hydroxamic acid

Liu, Y. H., Lin, S. Y., Lee, C. C. & Hou, W. C., Jul 1 2008, In : Food Chemistry. 109, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

hydroxamic acids
Hydroxamic Acids
galacturonic acid
nitric oxide
Nitric Oxide
14 Citations (Scopus)

Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells

Shih, C. R., Wu, J., Liu, Y., Liang, Y. C., Lin, S. Y., Sheu, M. T. & Lee, W. S., Jan 1 2004, In : Biochemical Pharmacology. 67, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Endothelial Cells
Phosphotransferases
Thymidine
21 Citations (Scopus)

Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest

Wu, C. H., Jeng, J. H., Wang, Y. J., Tseng, C. J., Liang, Y. C., Chen, C. H., Lee, H. M., Lin, J. K., Lin, C-H., Lin, S. Y., Li, C. P. & Ho, Y. S., Apr 1 2002, In : Toxicology and Applied Pharmacology. 180, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Miconazole
Heterografts
Nude Mice
Colon
2 Citations (Scopus)

A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of cushing's syndrome: A comparison with the standard high-dose dexamethasone suppression test

Lee, T. I. T. I., Lin, S. Y., Won, J. G. S., Tang, K. T., Jap, T. S., Kwok, C. F. & Lin, H. D., Jan 1 2003, In : Chinese Medical Journal (Taipei). 65, 10, p. 474-482 9 p.

Research output: Contribution to journalArticle

Cushing Syndrome
Corticotropin-Releasing Hormone
Dexamethasone
Sheep
Differential Diagnosis
74 Citations (Scopus)

Balthazar computed tomography severity index is superior to Ranson criteria and APACHE II scoring system in predicting acute pancreatitis outcome

Leung, T-K., Lee, C-M., Lin, S. Y., Chen, H. C., Wang, H. J., Shen, L. K. & Chen, Y. Y., Oct 14 2005, In : World Journal of Gastroenterology. 11, 38, p. 6049-6052 4 p.

Research output: Contribution to journalArticle

APACHE
Pancreatitis
Tomography
Spiral Computed Tomography
Hospitalization
4 Citations (Scopus)
docetaxel
Bispecific Antibodies
Lecithins
Drug Delivery Systems
Neoplasms
7 Citations (Scopus)

Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

Suk, F. M., Lin, S. Y., Lin, R-J., Hsine, Y. H., Liao, Y. J., Fang, S. U. & Liang, Y. C., 2015, In : Oncotarget. 6, 28, p. 25988-26001 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Burkitt Lymphoma
Down-Regulation
Cell Proliferation
Molecular Weight
18 Citations (Scopus)

Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells

Jayakumar, T., Chang, C. C., Lin, S. L., Huang, Y. K., Hu, C. M., Elizebeth, A. R., Lin, S. C. & Choy, C-S., 2014, In : BioMed Research International. 2014, 403703.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Computer aided manufacturing
Blood Vessels
Inflammation
1 Citation (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Histone Deacetylases
Calcitriol
Muscle Cells
Fibroblast Growth Factor 1
32 Citations (Scopus)
Calcitriol Receptors
Calcitriol
Tissue Inhibitor of Metalloproteinase-2
Procollagen
Angiotensin Type 1 Receptor
12 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Extracellular Signal-Regulated MAP Kinases
Cytoplasmic and Nuclear Receptors
Osteogenesis
RANK Ligand

CanMEDS角色與醫學生臨床情境認知之相容性探究

Translated title of the contribution: CanMEDS roles as framework for analyzing Taiwanese medical students’ reflective journals: an exploratory research for cross-cultural compatibility唐功培, 康以諾, 何建志, 曾櫻枝, 林宗達, 林時宜 & 陳建宇, 2015, In : 中榮醫教. 18, p. 21-28 8 p.

Research output: Contribution to journalArticle

role expectation
medical student
scenario
communicator
incompatibility
14 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Calcitriol
Diabetes Mellitus
Inflammation
Fatty Acids
7 Citations (Scopus)

Characteristics of patients with Clostridium difficile infection in Taiwan

Lin, Y. C., Huang, Y. T., Lee, T. F., Lee, N. Y., Liao, C. H., Lin, S. Y., Ko, W. C. & Hsueh, P. R., Oct 2013, In : Epidemiology and Infection. 141, 10, p. 2031-2038 8 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Taiwan
Genes
Mortality
23 Citations (Scopus)

Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis

Lin, S. Y., Chan, H. Y., Shen, F. H., Chen, M. H., Wang, Y. J. & Yu, C. K., Apr 15 2007, In : Journal of Cellular Biochemistry. 100, 6, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Chitosan
Cell Proliferation
Molecular Weight
Molecular weight
1 Citation (Scopus)

Chronic bifascicular block with intermittent complete atrioventricular block induced by hyperthyroidism

Kuo, Y. C., Tseng, Y. T., Lee, T. I. & Hsieh, M. H., Jun 28 2006, In : International Journal of Cardiology. 110, 3, p. 407-410 4 p.

Research output: Contribution to journalArticle

Atrioventricular Node
Atrioventricular Block
Hyperthyroidism
Heart Diseases
Electrocardiography
5 Citations (Scopus)
Colorectal Neoplasms
Epidemiology
Smoking
Microsatellite Instability
Neoplasms
71 Citations (Scopus)

Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action

Liu, D. Z., Liang, H. J., Chen, C. H., Su, C. H., Li, Z-H., Huang, C. T., Hou, W. C., Lin, S. Y., Zhong, W-B., Lin, P. J., Hung, L. F. & Liang, Y. C., Aug 15 2007, In : Journal of Ethnopharmacology. 113, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Microglia
Fermentation
Methanol
Anti-Inflammatory Agents
Neurodegenerative Diseases
142 Citations (Scopus)

Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes

Yu, W. L., Ko, W. C., Cheng, K-C., Lee, C. C., Lai, C-C. & Chuang, Y. C., Sep 2008, In : Diagnostic Microbiology and Infectious Disease. 62, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Liver Abscess
Klebsiella pneumoniae
Virulence Factors
Phenotype
Virulence

Correction: Surface-enhanced Raman scattering on a silver film-modified Au nanoparticle-decorated SiO2 mask array

Chang, C. C., Chen, L. Y., Yang, K. H., Chen, Q. Y., Liang, Y. C., Lin, S. Y. & Liu, Y. C., Aug 12 2015, In : RSC Advances. 5, 86, p. 70501 1 p.

Research output: Contribution to journalArticle

Silver
Raman scattering
Masks
Nanoparticles
11 Citations (Scopus)

Cytotoxicity of (-)-vitisin B in human leukemia cells

Wu, S. S., Chen, L. G., Lin, R-J., Lin, S. Y., Lo, Y. E. & Liang, Y. C., Jul 2013, In : Drug and Chemical Toxicology. 36, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

Resveratrol
Cell death
Cytotoxicity
Leukemia
Cell proliferation

Decellularized lymph node scaffolding as a carrier for dendritic cells to induce anti-tumor immunity

Lin, H. J., Wang, W., Huang, Y. Y., Liao, W. T., Lin, T. Y., Lin, S. Y. & Liu, D. Z., Nov 2019, In : Pharmaceutics. 11, 11, 553.

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Immunity
Lymph Nodes
Bone Marrow Cells
Ovalbumin

Deep Intronic Variant c.5999-277G>A of F8 Gene May Be a Hot-Spot Mutation for Mild Hemophilia A Patients Without Mutation in Exonic DNA

Chang, C-Y., Perng, C-L., Cheng, S-N., Hu, S-H., Wu, T-Y., Lin, S-Y. & Chen, Y-C., May 7 2019, In : European Journal of Haematology.

Research output: Contribution to journalArticle

Hemophilia A
Mutation
DNA
Exons
Genes
42 Citations (Scopus)
Patient Education
Blood Glucose
Fasting
Control Groups
Education
rosiglitazone
PPAR gamma
Diabetes Mellitus
Atrioventricular Block
Hypertension
1 Citation (Scopus)

Difference between observed and predicted glycated hemoglobin at baseline and treatment response to vildagliptin-based dual oral therapy in patients with type 2 diabetes

Wang, J. S., Hung, Y. J., Lu, Y. C., Tsai, C. L., Yang, W. S., Lee, T. I., Hsiao, Y. C. & Sheu, W. H. H., Apr 1 2018, In : Diabetes Research and Clinical Practice. 138, p. 119-127 9 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Fasting
Glucose
Therapeutics
1 Citation (Scopus)

Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes

Lu, Y. Y., Cheng, C. C., Tsai, C. F., Lin, Y. K., Lee, T. I., Chen, Y. C., Chen, S. A. & Chen, Y. J., Jun 1 2017, In : Clinical Science. 131, 12, p. 1317-1327 11 p.

Research output: Contribution to journalArticle

Ownership
Cardiac Myocytes
Heart Failure
Action Potentials
Tail
13 Citations (Scopus)

Does enhanced diabetes management reduce the risk and improve the outcome of tuberculosis?

Lo, H. Y., Yang, S. L., Lin, H. H., Bai, K. J., Lee, J. J., Lee, T. I. & Chiang, C. Y., Mar 1 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 3, p. 376-382 7 p.

Research output: Contribution to journalArticle

Risk Management
Diabetes Mellitus
Tuberculosis
National Health Programs
Incentive Reimbursement
15 Citations (Scopus)

Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

Cheng, T. C., Tu, S. H., Chen, L. C., Chen, M. Y., Chen, W. Y., Lin, Y-K., Ho, C. T., Lin, S. Y., Wu, C. H. & Ho, Y. S., 2015, In : Oncotarget. 6, 25, p. 21283-21300 18 p.

Research output: Contribution to journalArticle

alpha-L-Fucosidase
Triple Negative Breast Neoplasms
Glycosylation
Down-Regulation
Survival
5 Citations (Scopus)
Taiwanofungus camphoratus
Amine Oxidase (Copper-Containing)
Scavenging
amines
biphenyl
6 Citations (Scopus)

Effect of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents

Hsiao, F. C., Lin, Y. F., Hsieh, P. S., Chu, N. F., Chen, Y. D. I., Shieh, Y. S., Hsieh, C. H., Lee, C. H., Lee, T. I. & Hung, Y. J., 2014, In : International Journal of Endocrinology. 2014, 674069.

Research output: Contribution to journalArticle

Adiposity
Insulin Resistance
Inflammation
Genotype
Genes
5 Citations (Scopus)

Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Uen, Y. H., Wang, Y. J., Hsu, T. M., Chen, M. H., Chan, H. Y., Ho, Y. S. & Lin, S. Y., Sep 2008, In : Journal of Bioactive and Compatible Polymers. 23, 5, p. 458-472 15 p.

Research output: Contribution to journalArticle

Chitosan
Fluorouracil
Molecular Weight
Molecular weight
Bearings (structural)
6 Citations (Scopus)
Ganoderma lucidum
solid state fermentation
feed additives
prebiotics
broiler chickens
19 Citations (Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., Jun 15 2012, In : Food Chemistry. 132, 4, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Niacin
niacin
catechol oxidase
Antioxidants
33 Citations (Scopus)
Dioscorea alata
Dioscorea
yams
Blood pressure
Inbred SHR Rats
7 Citations (Scopus)

Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

Shih, S-L., Lin, Y-S., Lin, S-Y. & Hou, W-C., 2015, In : Botanical Studies. 56, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle