Department of General Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

2019

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology.

Research output: Contribution to journalArticle

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis

Decellularized lymph node scaffolding as a carrier for dendritic cells to induce anti-tumor immunity

Lin, H. J., Wang, W., Huang, Y. Y., Liao, W. T., Lin, T. Y., Lin, S. Y. & Liu, D. Z., Nov 2019, In : Pharmaceutics. 11, 11, 553.

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Immunity
Lymph Nodes
Bone Marrow Cells
Ovalbumin

Deep Intronic Variant c.5999-277G>A of F8 Gene May Be a Hot-Spot Mutation for Mild Hemophilia A Patients Without Mutation in Exonic DNA

Chang, C-Y., Perng, C-L., Cheng, S-N., Hu, S-H., Wu, T-Y., Lin, S-Y. & Chen, Y-C., May 7 2019, In : European Journal of Haematology.

Research output: Contribution to journalArticle

Hemophilia A
Mutation
DNA
Exons
Genes
1 Citation (Scopus)
Open Access
diabetes mellitus
Streptozocin
Medical problems
rats
Rats

Sodium hydrosulphide restores tumour necrosis factor-α-induced mitochondrial dysfunction and metabolic dysregulation in HL-1 cells

Lee, T. I., Kao, Y. H., Baigalmaa, L., Lee, T. W., Lu, Y. Y., Chen, Y. C., Chao, T. F. & Chen, Y. J., Jan 1 2019, (Accepted/In press) In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
Cardiac Myocytes
Oxidative Stress

Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases

Lee, T. W., Kao, Y. H., Chen, Y. J., Chao, T. F. & Lee, T. I., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalReview article

Vitamin D
Cardiovascular Diseases
Therapeutics
Vascular Stiffness
Advanced Glycosylation End Products
2018
Dioscorea
Glucose Intolerance
dipeptides
Dipeptides
yams
3 Citations (Scopus)

Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

Lkhagva, B., Kao, Y. H., Lee, T. I., Lee, T. W., Cheng, W. L. & Chen, Y. J., May 1 2018, (Accepted/In press) In : Epigenetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cardiac Myocytes
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
Enzymes
7 Citations (Scopus)

Aging modulates the substrate and triggers remodeling in atrial fibrillation

Lin, Y. K., Chen, Y. A., Lee, T. I., Chen, Y. C., Chen, S. A. & Chen, Y. J., Jan 1 2018, In : Circulation Journal. 82, 5, p. 1237-1244 8 p.

Research output: Contribution to journalReview article

Atrial Fibrillation
Atrial Remodeling
Muscular Diseases
Comorbidity
Veins
4 Citations (Scopus)
docetaxel
Bispecific Antibodies
Lecithins
Drug Delivery Systems
Neoplasms
1 Citation (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Histone Deacetylases
Calcitriol
Muscle Cells
Fibroblast Growth Factor 1
1 Citation (Scopus)

Difference between observed and predicted glycated hemoglobin at baseline and treatment response to vildagliptin-based dual oral therapy in patients with type 2 diabetes

Wang, J. S., Hung, Y. J., Lu, Y. C., Tsai, C. L., Yang, W. S., Lee, T. I., Hsiao, Y. C. & Sheu, W. H. H., Apr 1 2018, In : Diabetes Research and Clinical Practice. 138, p. 119-127 9 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Fasting
Glucose
Therapeutics
1 Citation (Scopus)
Histone Deacetylases
Autophagy
High Fat Diet
Nutrition
Streptozocin
1 Citation (Scopus)

MCPIP3 as a potential metastasis suppressor gene in human colorectal cancer

Suk, F. M., Chang, C. C., Lin, R. J., Lin, S. Y., Chen, Y. T. & Liang, Y. C., May 3 2018, In : International Journal of Molecular Sciences. 19, 5, 1350.

Research output: Contribution to journalArticle

Monocyte Chemoattractant Proteins
monocytes
suppressors
metastasis
Tumor Suppressor Genes
50 Citations (Scopus)

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

Que, X., Hung, M. Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Ylä-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J. & 2 others, Tsimikas, S. & Witztum, J. L., Jun 14 2018, In : Nature. 558, 7709, p. 301-306 6 p.

Research output: Contribution to journalArticle

Phospholipids
Macrophages
Atherosclerosis
Peritoneal Macrophages
Inflammation
2 Citations (Scopus)

Surface assembly of poly(I:C) on polyethyleneimine-modified gelatin nanoparticles as immunostimulatory carriers for mucosal antigen delivery

Lin, S. F., Jiang, P. L., Tsai, J. S., Huang, Y. Y., Lin, S. Y., Lin, J. H. & Liu, D. Z., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journalArticle

Polyethyleneimine
Poly I-C
Gelatin
Antigens
Ovalbumin
1 Citation (Scopus)

Using modified information delivery to enhance the traditional pharmacy OSCE program at TMU – a pilot study

Lin, C. W., Chang, E. H., Clinciu, D. L., Peng, Y. T., Huang, W. C., Wu, C. C., Wu, J. C. & Li, Y. C., May 1 2018, In : Computer Methods and Programs in Biomedicine. 158, p. 147-152 6 p.

Research output: Contribution to journalArticle

Students
Education
Aptitude
Prescriptions
Curricula
4 Citations (Scopus)

ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner

Suk, F-M., Chang, C-C., Lin, R-J., Lin, S-Y., Liu, S-C., Jau, C-F. & Liang, Y-C., Feb 9 2018, In : Scientific Reports. 8, 1, p. 2742

Research output: Contribution to journalArticle

Cyclin D
Cell Proliferation
Zinc Fingers
HCT116 Cells
Cyclin B
2017
5 Citations (Scopus)

ADAM10 modulates calcitriol-regulated RAGE in cardiomyocytes

Lee, T. W., Kao, Y. H., Lee, T. I. & Chen, Y. J., Sep 1 2017, In : European Journal of Clinical Investigation. 47, 9, p. 675-683 9 p.

Research output: Contribution to journalArticle

Disintegrins
Calcitriol Receptors
Calcitriol
Metalloproteases
Cardiac Myocytes
1 Citation (Scopus)

Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes

Lu, Y. Y., Cheng, C. C., Tsai, C. F., Lin, Y. K., Lee, T. I., Chen, Y. C., Chen, S. A. & Chen, Y. J., Jun 1 2017, In : Clinical Science. 131, 12, p. 1317-1327 11 p.

Research output: Contribution to journalArticle

Ownership
Cardiac Myocytes
Heart Failure
Action Potentials
Tail
2 Citations (Scopus)

Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice

Lu, Y. L., Lin, S. Y., Fang, S. U., Hsieh, Y. Y., Chen, C. R., Wen, C. L., Chang, C. I. & Hou, W. C., Mar 29 2017, In : Journal of Agricultural and Food Chemistry. 65, 12, p. 2521-2529 9 p.

Research output: Contribution to journalArticle

viniferins
Vitis
High Fat Diet
high fat diet
Nutrition
4 Citations (Scopus)

Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease

Chang, W. H., Niu, D. M., Lu, C. Y., Lin, S. Y., Liu, T. C. & Chang, J. G., Apr 1 2017, In : PLoS One. 12, 4, e0175929.

Research output: Contribution to journalArticle

Fabry Disease
Amiloride
alternative splicing
Alternative Splicing
Histone Code
16 Citations (Scopus)

PPARs modulate cardiac metabolism and mitochondrial function in diabetes

Lee, T. W., Bai, K. J., Lee, T. I., Chao, T. F., Kao, Y. H. & Chen, Y. J., Jan 10 2017, In : Journal of Biomedical Science. 24, 1, 5.

Research output: Contribution to journalReview article

Diabetic Cardiomyopathies
Peroxisome Proliferator-Activated Receptors
Medical problems
Metabolism
Mitochondria
1 Citation (Scopus)

Primary Sjogren's syndrome and the risk of acute pancreatitis: A nationwide cohort study

Chang, C. C., Chang, Y. S., Wang, S. H., Lin, S. Y., Chen, Y. H. & Chen, J. H., Aug 1 2017, In : BMJ Open. 7, 8, e014807.

Research output: Contribution to journalArticle

Sjogren's Syndrome
Pancreatitis
Cohort Studies
Taiwan
Population

Rotura traqueal yatrogénica tras una intubación de urgencia

Translated title of the contribution: Iatrogenic Tracheal Rupture After Emergent IntubationChou, C. L., Lee, T. I. & Hu, T. Y., Feb 1 2017, In : Archivos de Bronconeumologia. 53, 2, p. 75-76 2 p.

Research output: Contribution to journalArticle

Intubation
Rupture
3 Citations (Scopus)
Thyroid Diseases
Thyrotropin
Autoimmune Diseases
Hashimoto Disease
Thyroidectomy
2016
13 Citations (Scopus)

Does enhanced diabetes management reduce the risk and improve the outcome of tuberculosis?

Lo, H. Y., Yang, S. L., Lin, H. H., Bai, K. J., Lee, J. J., Lee, T. I. & Chiang, C. Y., Mar 1 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 3, p. 376-382 7 p.

Research output: Contribution to journalArticle

Risk Management
Diabetes Mellitus
Tuberculosis
National Health Programs
Incentive Reimbursement
8 Citations (Scopus)
Pulmonary Veins
Cardiac Myocytes
Fibroblast Growth Factor 1
Homeostasis
Sodium
9 Citations (Scopus)

Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes

Huang, J. H., Chen, Y. C., Lee, T. I., Kao, Y. H., Chazo, T. F., Chen, S. A. & Chen, Y. J., Apr 1 2016, In : Peptides. 78, p. 91-98 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Cardiac Myocytes
Homeostasis
Calcium
Ryanodine Receptor Calcium Release Channel
14 Citations (Scopus)

HDAC inhibition modulates cardiac PPARs and fatty acid metabolism in diabetic cardiomyopathy

Lee, T. I., Kao, Y. H., Tsai, W. C., Chung, C. C., Chen, Y. C. & Chen, Y. J., 2016, In : PPAR Research. 2016, 5938740.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Peroxisome Proliferator-Activated Receptors
Histone Deacetylases
Diabetes Mellitus
Fatty Acids

Iatrogenic tracheal rupture after emergent intubation

Chou, C. L., Lee, T. I. & Hu, T. Y., 2016, (Accepted/In press) In : Archivos de Bronconeumologia.

Research output: Contribution to journalArticle

Intubation
Rupture
1 Citation (Scopus)

Successful multivessel percutaneous coronary intervention for acute coronary syndrome in a HIV-positive severe haemophiliac

Chang, C. Y., Lin, S. Y., Tsai, J. R., Tsai, C. H. & Chen, Y. C., Sep 1 2016, In : Haemophilia. 22, 5, p. e481-e484

Research output: Contribution to journalLetter

Percutaneous Coronary Intervention
Acute Coronary Syndrome
HIV
6 Citations (Scopus)
Dioscorea
Dipeptidyl Peptidase 4
yams
glucose tolerance
Glucose Tolerance Test

翻轉教學應用於擬真臨床技能學習之滿意度初探

Translated title of the contribution: An Exploratory Study on Simulated Clinical Skill Learning Satisfaction in the Flipped Approach康以諾, 林哲瑋(Che-Wei L, 陳建宇(Jonathan C-Y C, 曾德銘(Te-Ming T & 吳建志(Chien-Chih W, 2016, In : 台灣擬真醫學教育期刊. 3, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

learning
classroom
student
manpower
medical student
2015
7 Citations (Scopus)

Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

Suk, F. M., Lin, S. Y., Lin, R-J., Hsine, Y. H., Liao, Y. J., Fang, S. U. & Liang, Y. C., 2015, In : Oncotarget. 6, 28, p. 25988-26001 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Burkitt Lymphoma
Down-Regulation
Cell Proliferation
Molecular Weight
11 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Extracellular Signal-Regulated MAP Kinases
Cytoplasmic and Nuclear Receptors
Osteogenesis
RANK Ligand

CanMEDS角色與醫學生臨床情境認知之相容性探究

Translated title of the contribution: CanMEDS roles as framework for analyzing Taiwanese medical students’ reflective journals: an exploratory research for cross-cultural compatibility唐功培, 康以諾, 何建志, 曾櫻枝, 林宗達, 林時宜 & 陳建宇, 2015, In : 中榮醫教. 18, p. 21-28 8 p.

Research output: Contribution to journalArticle

role expectation
medical student
scenario
communicator
incompatibility

Correction: Surface-enhanced Raman scattering on a silver film-modified Au nanoparticle-decorated SiO2 mask array

Chang, C. C., Chen, L. Y., Yang, K. H., Chen, Q. Y., Liang, Y. C., Lin, S. Y. & Liu, Y. C., Aug 12 2015, In : RSC Advances. 5, 86, p. 70501 1 p.

Research output: Contribution to journalArticle

Silver
Raman scattering
Masks
Nanoparticles
15 Citations (Scopus)

Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

Cheng, T. C., Tu, S. H., Chen, L. C., Chen, M. Y., Chen, W. Y., Lin, Y-K., Ho, C. T., Lin, S. Y., Wu, C. H. & Ho, Y. S., 2015, In : Oncotarget. 6, 25, p. 21283-21300 18 p.

Research output: Contribution to journalArticle

alpha-L-Fucosidase
Triple Negative Breast Neoplasms
Glycosylation
Down-Regulation
Survival
6 Citations (Scopus)
Ganoderma lucidum
solid state fermentation
feed additives
prebiotics
broiler chickens
7 Citations (Scopus)

Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

Shih, S-L., Lin, Y-S., Lin, S-Y. & Hou, W-C., 2015, In : Botanical Studies. 56, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Lin, Y. S., Wu, W. C., Lin, S. Y. & Hou, W. C., 2015, In : Amino Acids. 47, 3, p. 617-625 9 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Melanins
Glycine
Down-Regulation
Agaricales
20 Citations (Scopus)

High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Simon-Loriere, E., Lin, R-J., Kalayanarooj, S. M., Chuansumrit, A., Casademont, I., Lin, S. Y., Yu, H. P., Lert-Itthiporn, W., Chaiyaratana, W., Tangthawornchaikul, N., Tangnararatchakit, K., Vasanawathana, S., Chang, B. L., Suriyaphol, P., Yoksan, S., Malasit, P., Despres, P., Paul, R., Lin, Y. L. & Sakuntabhai, A., 2015, In : Journal of Infectious Diseases. 212, 12, p. 2011-2020 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Genes
Virus Diseases
Antiviral Agents
18 Citations (Scopus)
Critical Care
Methicillin-Resistant Staphylococcus aureus
Intensive Care Units
Costs and Cost Analysis
Mortality
9 Citations (Scopus)

Increased risk of hepatocellular carcinoma in chronic hepatitis C patients with new onset diabetes: A nation-wide cohort study

Huang, Y. W., Wang, T. C., Yang, S. S., Lin, S. Y., Fu, S. C., Hu, J. T., Liu, C. J., Kao, J. H. & Chen, D. S., Oct 1 2015, In : Alimentary Pharmacology and Therapeutics. 42, 7, p. 902-911 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Hepatocellular Carcinoma
Cohort Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mortality
9 Citations (Scopus)

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation

Kao, Y. T., Chang, B. L., Liang, J. J., Tsai, H. J., Lee, Y. L., Lin, R. J. & Lin, Y. L., Mar 1 2015, In : PLoS Pathogens. 11, 3, p. 1-26 26 p., e1004750.

Research output: Contribution to journalArticle

Mitochondrial Trifunctional Protein
Japanese Encephalitis Virus
Fatty Acids
Proteins
Cytokines
5 Citations (Scopus)

Managing mass events and competitions with difficult-to-access locations using mobile electrocardiac monitoring

Shih, C-M., Lin, C-W., Clinciu, D. L., Jian, W-S., Kuo, T. B. J., Nguyen, P. A., Usman, I., Hsu, C. K., Owili, P. O. & Li, Y-C., Apr 13 2015, (Accepted/In press) In : Computer Methods and Programs in Biomedicine. 121, 2, p. 109-115

Research output: Contribution to journalArticle

Wireless Technology
Emergencies
Monitoring
Cardiac Arrhythmias
Electrocardiography
7 Citations (Scopus)

N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK

Lee, W. H., Wu, H. H., Huang, W. J., Li, Y. N., Lin, R-J., Lin, S. Y. & Liang, Y. C., Mar 1 2015, In : Molecules. 20, 3, p. 4516-4529 14 p.

Research output: Contribution to journalArticle

hyperglycemia
AMP-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
glucose
Hyperglycemia
2 Citations (Scopus)

Pheochromocytoma presenting as hyperglycemic hyperosmolar syndrome and unusual fever

Lee, I. S., Lee, T. W., Chang, C. J., Chien, Y. M. & Lee, T. I., Mar 3 2015, In : Internal and Emergency Medicine. 10, 6, p. 753-755 3 p.

Research output: Contribution to journalArticle

Hyperglycemic Hyperosmolar Nonketotic Coma
Adrenal Gland Neoplasms
Pheochromocytoma
Body Mass Index
Fever
11 Citations (Scopus)

Potential of vitamin D in treating diabetic cardiomyopathy

Lee, T. W., Lee, T. I., Chang, C. J., Lien, G. S., Kao, Y. H., Chao, T. F. & Chen, Y. J., Apr 1 2015, In : Nutrition Research. 35, 4, p. 269-279 11 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Vitamin D
Diabetes Mellitus
Cardiovascular Diseases
Hyperphosphatemia