Department of Biochemistry and Molecular Cell Biology

Research Output 1994 2020

2020

Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells

Balamurugan, T. S. T., Chen, G. Z., Kumaravel, S., Lin, C. M., Huang, S. T., Lee, Y. C., Chen, C. H. & Luo, G. R., Feb 15 2020, In : Biosensors and Bioelectronics. 150, 111948.

Research output: Contribution to journalArticle

Open Access
Publications
Hepatocellular Carcinoma
Interleukin-6
Research
Neoplasms
2019

A bioinspired hyperthermic macrophage-based polypyrrole-polyethylenimine (Ppy-PEI) nanocomplex carrier to prevent and disrupt thrombotic fibrin clots

Burnouf, T., Chen, C. H., Tan, S. J., Tseng, C. L., Lu, K. Y., Chang, L. H., Nyambat, B., Huang, S. C., Jheng, P. R., Aditya, R. N., Mi, F. L. & Chuang, E. Y., Sep 15 2019, In : Acta Biomaterialia. 96, p. 468-479 12 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Macrophages
Polypyrroles
Fibrin
Radiation
4 Citations (Scopus)

A double-virally-inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells

Barro, L., Su, Y. T., Nebie, O., Wu, Y. W., Huang, Y. H., Koh, M. B. C., Knutson, F. & Burnouf, T., Jan 1 2019, In : Transfusion.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Detergents
Blood Platelets
Serum
In Vitro Techniques
13 Citations (Scopus)

A novel injectable in situ forming gel based on carboxymethyl hexanoyl chitosan/hyaluronic acid polymer blending for sustained release of berberine

Lu, K. Y., Lin, Y. C., Lu, H. T., Ho, Y. C., Weng, S. C., Tsai, M. L. & Mi, F. L., Feb 15 2019, In : Carbohydrate Polymers. 206, p. 664-673 10 p.

Research output: Contribution to journalArticle

Berberine
Hyaluronic acid
Hyaluronic Acid
Chitosan
Polymers
11 Citations (Scopus)
Chitosan
Durapatite
Tissue Engineering
Scaffolds (biology)
Tissue engineering
4 Citations (Scopus)

Development of injectable fucoidan and biological macromolecules hybrid hydrogels for intra-articular delivery of platelet-rich plasma

Lu, H. T., Chang, W. T., Tsai, M. L., Chen, C. H., Chen, W. Y. & Mi, F. L., Jan 1 2019, In : Marine Drugs. 17, 4, 236.

Research output: Contribution to journalArticle

Open Access
Hydrogels
Platelet-Rich Plasma
Hyaluronic Acid
Gelatin
Joints
15 Citations (Scopus)
Chitosan
Nanoparticles
Insulin
Medical problems
Glucosidases
1 Citation (Scopus)

DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

Lai, S. C., Su, Y. T., Chi, C. C., Kuo, Y. C., Lee, K. F., Wu, Y. C., Lan, P. C., Yang, M. H., Chang, T. S. & Huang, Y. H., Nov 26 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 474.

Research output: Contribution to journalArticle

Open Access
Octamer Transcription Factors
Methyltransferases
Hepatocellular Carcinoma
Interleukin-6
DNA
1 Citation (Scopus)

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
Rehmannia
Aromatase
ferulic acid
Polyphenols
Estradiol
2 Citations (Scopus)

Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

Lee, C., Liao, J., Chen, S., Yen, C., Lee, Y., Huang, S., Huang, S., Lin, C. M. & Chang, V. H., 2019, In : Frontiers in Pharmacology. 10, p. 91

Research output: Contribution to journalArticle

Fluorine
Cyclooxygenase 2
Anti-Inflammatory Agents
Lung
Myofibroblasts
1 Citation (Scopus)

High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Shih, H. C., Chang, M. C., Chen, C. H., Tsai, I. L., Wang, S. Y., Kuo, Y. P., Chen, C. H. & Chang, Y. T., Jan 3 2019, In : Clinical Proteomics. 16, 1

Research output: Contribution to journalArticle

Open Access
Glycosylation
Pancreatitis
Adenocarcinoma
Immunoglobulin G
Regression Analysis
Ventilator-Induced Lung Injury
Continuous Positive Airway Pressure
Lung Injury
Pneumonia
Respiration

Increasing electrochemical reaction rates using treated water with reduced hydrogen bonds

Yang, C. P., Hong, C. T., Mai, F. D., Tsai, H. Y. & Liu, Y. C., Apr 15 2019, In : Journal of Electroanalytical Chemistry. 839, p. 116-122 7 p.

Research output: Contribution to journalArticle

Reaction rates
Hydrogen bonds
Water
Deionized water
Electrolytes
2 Citations (Scopus)

Isothermal titration calorimetry for characterization of recombinant proteins

Baranauskiene, L., Kuo, T. C., Chen, W. Y. & Matulis, D., Feb 1 2019, In : Current Opinion in Biotechnology. 55, p. 9-15 7 p.

Research output: Contribution to journalReview article

Recombinant proteins
Calorimetry
Titration
Recombinant Proteins
Drug Design

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, p. 110808 110808.

Research output: Contribution to journalArticle

leptin (116-130)
hepatoma
Leptin
leptin
Hepatocellular Carcinoma
7 Citations (Scopus)

Metabolome analysis for investigating host-gut microbiota interactions

Chen, M. X., Wang, S. Y., Kuo, C. H. & Tsai, I. L., Mar 2019, In : Journal of the Formosan Medical Association.

Research output: Contribution to journalArticle

Metabolome
Mass Spectrometry
Metabolomics
Dysbiosis
Microbiota
1 Citation (Scopus)

Metastatic colorectal cancer rewrites metabolic program through a Glut3-YAP-dependent signaling circuit

Kuo, C. C., Ling, H. H., Chiang, M. C., Chung, C. H., Lee, W. Y., Chu, C. Y., Wu, Y. C., Chen, C. H., Lai, Y. W., Tsai, I. L., Cheng, C. H. & Lin, C. W., Jan 1 2019, In : Theranostics. 9, 9, p. 2526-2540 15 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Neoplasm Metastasis
Colonic Neoplasms
Neoplasms
Proteins
3 Citations (Scopus)
Endometriosis
Estrogen Receptors
Apoptosis
Mitochondria
Mitochondrial DNA

Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells

Wong, J. H., Wang, Y. S., Nam, S., Ho, K. H., Chang, C. M., Chen, K. C., Chen, Y. F. & Chang, W. C., Jan 1 2019, In : Environmental Toxicology.

Research output: Contribution to journalArticle

Plasticizers
phthalate
Cyclooxygenase 2
Stomach
Adenocarcinoma

Plasmon-Activated Water can Prolong Existing Sea-Ice Habitats to Potentially Save Polar Bears

Yang, C. P., Wu, Y. H., Tsai, H. Y., Yang, J. C. & Liu, Y. C., Dec 1 2019, In : Scientific Reports. 9, 1, 10398.

Research output: Contribution to journalArticle

Open Access
Ursidae
Ice Cover
Ecosystem
Water
Ice

Plasmon-Activated Water Reduces Amyloid Burden and Improves Memory in Animals with Alzheimer’s Disease

Cheng, C. H., Lin, K. J., Hong, C. T., Wu, D., Chang, H. M., Liu, C. H., Hsiao, I. T., Yang, C. P., Liu, Y. C. & Hu, C. J., Dec 1 2019, In : Scientific Reports. 9, 1, 13252.

Research output: Contribution to journalArticle

Open Access

Potential of Plasmon-Activated Water as a Comprehensive Active Green Energy Resource

Chen, H. C., Yang, C. P., Hong, C. T., Hsu, C. T., Hu, C. C. & Liu, Y. C., May 2 2019, In : ACS Omega. 4, 5, p. 8007-8014 8 p.

Research output: Contribution to journalArticle

Open Access
Energy resources
Deionized water
Water
Platinum
Hydrogen
1 Citation (Scopus)

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Fan, J. J., Hsu, W. H., Hung, H. H., Zhang, W. J., A Lee, Y. L., Chen, K. C., Chu, C. Y., Ko, T. P., Lee, M. T., Lin, C. W. & Cheng, C. H., Apr 1 2019, In : International Journal of Oncology. 54, 5, p. 1639-1650 12 p.

Research output: Contribution to journalArticle

Open Access
Superoxide Dismutase
Squamous Cell Carcinoma
Reactive Oxygen Species
Luteolin
Cell Line

Strategy on Persisting in Distinct Activity of Plasmon-Activated Water

Yang, C. P., Tsai, H. Y., Tseng, C. L., Hao, P. J. & Liu, Y. C., Dec 17 2019, In : ACS Omega. 4, 25, p. 21197-21203 7 p.

Research output: Contribution to journalArticle

Open Access
Water
Deionized water
Liquids
Liquid nitrogen
Vapor pressure

The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells

Yang, C. E., Lee, W. Y., Cheng, H. W., Chung, C. H., Mi, F. L. & Lin, C. W., Apr 1 2019, In : Chemico-Biological Interactions. 302, p. 28-35 8 p.

Research output: Contribution to journalArticle

Chlorpromazine
Drug Resistance
Antipsychotic Agents
Stem cells
Cells

The expression profile and prognostic significance of metallothionein genes in colorectal cancer

Hung, K. C., Huang, T. C., Cheng, C. H., Cheng, Y. W., Lin, D. Y., Fan, J. J. & Lee, K. H., Aug 2 2019, In : International Journal of Molecular Sciences. 20, 16, 3849.

Research output: Contribution to journalArticle

Open Access
Metallothionein
genes
Colorectal Neoplasms
Genes
cancer
6 Citations (Scopus)

Triple-negative breast cancer: Current understanding and future therapeutic breakthrough targeting cancer stemness

Lee, K. L., Kuo, Y. C., Ho, Y. S. & Huang, Y. H., Sep 2019, In : Cancers. 11, 9, 1334.

Research output: Contribution to journalReview article

Open Access
Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Neoplasms
Therapeutics
Breast Neoplasms
2018
5 Citations (Scopus)

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Fibroblasts
Nicotine
Chemical activation
Cells
3 Citations (Scopus)

Active Tumor-Targeted co-Delivery of Epigallocatechin Gallate and Doxorubicin in Nanoparticles for Combination Gastric Cancer Therapy

Mi, F. L., Wang, L. F., Chu, P. Y., Peng, S. L., Feng, C. L., Lai, Y. J., Li, J. N. & Lin, Y. H., Aug 13 2018, In : ACS Biomaterials Science and Engineering. 4, 8, p. 2847-2859 13 p.

Research output: Contribution to journalArticle

Doxorubicin
Tumors
Cells
Nanoparticles
Hyaluronic acid
21 Citations (Scopus)

Antibacterial effects of chitosan/cationic peptide nanoparticles

Tamara, F. R., Lin, C., Mi, F. L. & Ho, Y. C., Feb 5 2018, In : Nanomaterials. 8, 2, 88.

Research output: Contribution to journalArticle

Chitosan
Protamines
Peptides
Nanoparticles
Bacillus cereus
9 Citations (Scopus)

Development of a general method for quantifying IgG-based therapeutic monoclonal antibodies in human plasma using protein G purification coupled with a two internal standard calibration strategy using LC-MS/MS

Chiu, H. H., Liao, H. W., Shao, Y. Y., Lu, Y. S., Lin, C. H., Tsai, I. L. & Kuo, C. H., Jan 1 2018, (Accepted/In press) In : Analytica Chimica Acta.

Research output: Contribution to journalArticle

Calibration
antibody
Purification
purification
Blood Proteins
10 Citations (Scopus)
Biomineralization
Nanocomposites
Tissue Engineering
Scaffolds (biology)
Tissue engineering
28 Citations (Scopus)

Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films

Tsai, Y. H., Yang, Y. N., Ho, Y. C., Tsai, M. L. & Mi, F. L., Jan 15 2018, In : Carbohydrate Polymers. 180, p. 286-296 11 p.

Research output: Contribution to journalArticle

Zein
Silymarin
Composite films
Nanofibers
Antioxidants
2 Citations (Scopus)
Intracytoplasmic Sperm Injections
Gonadotropin-Releasing Hormone
Oocytes
Meta-Analysis
Pregnancy Rate
1 Citation (Scopus)

Effectively reducing reagent concentrations for electrochemical reactions in aqueous solutions using plasmon-activated water

Yang, C. P., Fang, S. U., Yang, K. H., Tsai, H. Y. & Liu, Y. C., Jun 1 2018, In : Journal of Electroanalytical Chemistry. 818, p. 44-50 7 p.

Research output: Contribution to journalArticle

Deionized water
Water
Electrolytes
Hydrogen
Oxygen
9 Citations (Scopus)

Effective reduction of water molecules' interaction for efficient water evaporation in desalination

Chen, H. C., Chen, Y. R., Yang, K. H., Yang, C. P., Tung, K. L., Lee, M. J., Shih, J. H. & Liu, Y. C., Jun 15 2018, In : Desalination. 436, p. 91-97 7 p.

Research output: Contribution to journalArticle

Desalination
desalination
Evaporation
evaporation
Molecules
2 Citations (Scopus)

Effect of teapot materials on the chemical composition of oolong tea infusions

Liao, Z. H., Chen, Y. J., Tzen, J. T. C., Kuo, P. C., Lee, M. R., Mai, F. D., Rairat, T. & Chou, C. C., Jan 30 2018, In : Journal of the Science of Food and Agriculture. 98, 2, p. 751-757 7 p.

Research output: Contribution to journalArticle

Tea
tea
chemical composition
ceramics
stainless steel
10 Citations (Scopus)

Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction

Chen, K. C., Hsu, W. H., Ho, J. Y., Lin, C. W., Chu, C. Y., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Luteolin
luteolin
Quercetin
Flavonoids
metastasis
3 Citations (Scopus)

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set

Ho, K-H., Chang, C-J., Huang, T-W., Shih, C-M., Liu, A-J., Chen, P-H., Cheng, K-T. & Chen, K-C., Dec 1 2018, In : PLoS One. 13, 12, p. e0208459 e0208459.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Horseradish Peroxidase-Encapsulated Hollow Silica Nanospheres for Intracellular Sensing of Reactive Oxygen Species

Chen, H-Y., Wu, S-H., Chen, C-T., Chen, Y-P., Chang, F-P., Chien, F-C. & Mou, C-Y., Apr 24 2018, In : Nanoscale Research Letters. 13, 1, p. 123

Research output: Contribution to journalArticle

Nanospheres
Horseradish Peroxidase
Silicon Dioxide
hollow
Reactive Oxygen Species
9 Citations (Scopus)

IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Kuo, Y. C., Au, H. K., Hsu, J. L., Wang, H. F., Lee, C. J., Peng, S. W., Lai, S. C., Wu, Y. C., Ho, H. N. & Huang, Y. H., Feb 13 2018, In : Stem Cell Reports. 10, 2, p. 524-537 14 p.

Research output: Contribution to journalArticle

Stem cells
Germ Cells
Alkaline Phosphatase
Stem Cells
Insulin-Like Growth Factor I
3 Citations (Scopus)

Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water

Wang, C-K., Chen, H-C., Fang, S-U., Ho, C-W., Tai, C-J., Yang, C-P. & Liu, Y-C., Dec 1 2018, In : Scientific Reports. 8, 1, p. 6316 6316.

Research output: Contribution to journalArticle

Drinking
Lung Neoplasms
Water
Cisplatin
Therapeutics
2 Citations (Scopus)

Melanogenesis inhibitors from the rhizoma of ligusticum sinense in B16-f10 melanoma cells in vitro and zebrafish in vivo

Cheng, M. C., Lee, T. H., Chu, Y. T., Syu, L. L., Hsu, S. J., Cheng, C. H., Wu, J. & Lee, C. K., Dec 1 2018, In : International Journal of Molecular Sciences. 19, 12, 3994.

Research output: Contribution to journalArticle

Ligusticum
Experimental Melanomas
ferulic acid
Cosmetics
Zebrafish

Method development of immunoglobulin G purification from micro-volumes of human serum for untargeted and targeted proteomics-based antibody repertoire studies

Chang, Y. T., Chang, M. C., Tsai, Y. J., Ferng, C., Shih, H. C., Kuo, Y. P., Chen, C. H. & Tsai, I. L., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

immunoglobulin G
Proteomics
proteomics
Immunoglobulin G
purification methods
5 Citations (Scopus)

microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells

Chen, P. H., Liu, A. J., Ho, K. H., Chiu, Y. T., Anne Lin, Z. H., Lee, Y. T., Shih, C. M. & Chen, K. C., Aug 1 2018, In : Chemico-Biological Interactions. 291, p. 144-151 8 p.

Research output: Contribution to journalArticle

Autophagy
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MicroRNAs
Pharmaceutical Preparations
3 Citations (Scopus)

miR-4725-3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion

Ho, K. H., Chang, C. K., Chen, P. H., Wang, Y. J., Chang, W. C. & Chen, K. C., Aug 1 2018, In : Journal of Neurochemistry. 146, 3, p. 269-288 20 p.

Research output: Contribution to journalArticle

Glioma
Molecules
Glioblastoma
Humulus
Tumors
Pancreatic Ribonuclease
Calorimetry
Surface charge
Chromatography
Titration
27 Citations (Scopus)

Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs

Chen, C-H., Lin, Y-S., Wu, S-J. & Mi, F-L., Aug 1 2018, In : Carbohydrate Polymers. 193, p. 163-172 10 p.

Research output: Contribution to journalArticle

Arginine
Chitosan
Nanoparticles
Pharmaceutical Preparations
Curcumin
4 Citations (Scopus)

Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy

Lin, P. Y., Chiu, Y. L., Huang, J. H., Chuang, E. Y., Mi, F. L., Lin, K. J., Juang, J. H., Sung, H. W. & Leong, K. W., Aug 1 2018, In : Advanced Science. 5, 8, 1701079.

Research output: Contribution to journalArticle

insulin
plasmids
Insulin
genes
therapy