College of Medicine

Projects

Projects per year 2010 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2026

• 2 Not started
• 113 Active
• 2906 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Neoplasms 100%
  • Proteins 87%
  • MicroRNAs 61%
  • Radio 56%
  • Areca 53%

• The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells

  Sheu, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aldehyde Reductase 100%
  • Platelet Activation 32%
  • Blood Platelets 28%
  • convulxin 26%
  • epalrestat 21%

• The Impact of Environmental Change on Spatial and Temporal Variations of Dengue Outbreaks-- Part Ii

  Chuang, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • mosquito 100%
  • land cover 91%
  • dengue fever 83%
  • climate 60%
  • environmental factor 46%

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Remote sensing 100%
  • Land use 87%
  • Satellites 74%
  • Alarm systems 54%
  • Land surface temperature 46%

• The Implication of Plasminogen Activator Inhibitor-1 in the Regulation of Thrombin-Induced Fibrogenesis in Inflammatory Pleural Effusions.

  Chung, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Plasminogen Activator Inhibitor 1 100%
  • Thrombin 81%
  • Fibrosis 40%
  • Collagen 18%
  • Pleural Effusion 17%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myofibroblasts 100%
  • Endothelin-1 85%
  • Fibrosis 70%
  • Pulmonary Fibrosis 54%
  • Epithelial-Mesenchymal Transition 49%

• Deep Learning-based analysis with Multi-Omics data for prognosis prediction of Prostate Cancer

  Chang, T.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Longitudinal Analysis Combining Neuroimage and Proteomic Studies on Fibromyalgia Patients

  Kang, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討缺氧誘導之 lncRNA MIR210HG 在腦瘤惡性進程及促進 temozolomide 藥物抗藥性機轉中角色，並評估其作為腦瘤治療標的之可行性

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

  Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • Stem Cells 31%
  • pifithrin 27%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 39%
  • Neoplasms 36%
  • Breast Neoplasms 25%
  • Psychological Inhibition 19%

• The Neuroprotection Effect and Mechanism of Long Non-Coding RNA MALAT1 in Acute Ischemic Stroke

  Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Long Noncoding RNA 67%
  • Ischemia 47%
  • Untranslated RNA 47%
  • Cell Line 24%

• Investigating a Novel Cancer Stem Cell Biomarker Podocalyxin-Like Protein 1 Promotes Epithelial-Mesenchymal Transition and Cancer Stemness in Breast Cancer Cells

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • podocalyxin 100%
  • Neoplastic Stem Cells 43%
  • Epithelial-Mesenchymal Transition 26%
  • Proteins 24%
  • Breast Neoplasms 22%

• Characterization of the Self-Renewal/Reprogramming Factors of Human/Mouse Germ Line Stem Cells in Serum-Free Culture System and Its Induction Effect on Human Embryonic Stem Cells to Sperm (Extension Proposal) (II)

  Huang, Y.

  12/1/10 → 9/30/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stem cells 100%
  • germ cells 94%
  • hypoxia 45%
  • translational medical research 38%
  • testes 30%

• Gender Difference in the Complications and Mortality of Hospitalized Patients: Surgery and Anesthesia, Intensive Care Unit, Stroke, and Diabetes (Main Point: V03)

  Liao, C.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Critical Care 100%
  • Stroke 62%
  • Intensive Care Units 37%
  • Taiwan 33%
  • Mortality 22%

• Association of Peroxisome Proliferator-Activated Receptors, PPAR-Mediated Genes and Ischemic Stroke

  Chiou, H. & Hu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Peroxisome Proliferator-Activated Receptors 99%
  • Genes 33%
  • Oxidized LDL Receptors 30%
  • Coenzyme A Ligases 27%

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder: an 8-Week Randomized, Double-Blind, Placebo-Controlled Trial

  Chen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Translational Investigation of the Role of Myc/Pd-L1/Akt Axis as a Therapeutic Target for Treating Glioblastoma Multiforme

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Characterisitc of Trapezius Surface Myography during Sleep

  Kang, J., Hu, C., Chen, S. & Tseng, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Superficial Back Muscles 100%
  • Myalgia 51%
  • Sleep 36%
  • Posture 8%
  • Myofascial Pain Syndromes 6%

• Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation: an in vivo Transgenic Mouse Model (II)

  Chen, C., Tzeng, C. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sphingosine 100%
  • vascular endothelial growth factors 67%
  • phosphates 52%
  • female fertility 30%
  • autografting 18%

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence

  Yang, J., Yang, S. & Huang, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • muscle contraction 100%
  • reflexes 85%
  • urinary incontinence 55%
  • muscles 43%
  • perineum 25%

• Mri Study on Trans-Neuronal Degeneration of the Thalamic Networks after Ischemic Stroke

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thalamus 100%
  • Stroke 96%
  • Thalamic Nuclei 52%
  • Cerebral Infarction 43%
  • Gait 38%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture(2/3)

  Chen, R.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• The Protective Role of Hmg-Coa Reductase Inhibitor，Statins，In Postoperative Complications and Survival of Critically Ill Subjects

  Chen, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Novel Collagen Composite Containing MSC-EVs Improves Achilles Tendon Repair

  Huang, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bilateral Parietal-Prefrontal and Glutamatergic Activity in Schizophrenia Patients--Fmri, Rsmri, and Mrs Investigation

  Lane, T. J., Lin, I., Tseng, P. & Lu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Schizophrenia 100%
  • Clinical Trial Protocols 93%
  • Glutamic Acid 53%
  • Electroencephalography 52%
  • Magnetic Resonance Imaging 40%

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)

  Chen, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Community's Prevalence of Silent Brain Infarction and the Association between Inflammatory Markers, Polymorphisms and Silent Brain Infarction

  Bai, C., Chen, W. & Chen, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Brain Infarction 100%
  • Interleukin-6 23%
  • Single Nucleotide Polymorphism 10%
  • Arteries 8%
  • Stroke 8%

• The Comparison of Complications and Mortality after Surgery between General Anesthesia and Regional Anesthesia in the Elderly(2/2)

  Liao, C.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Conduction Anesthesia 100%
  • General Anesthesia 89%
  • Elderly 42%
  • Mortality 35%
  • Postoperative Complications 30%

• Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Activating Transcription Factor 3 in the Protective Effect of Resveratrol in Cardiomyocytes

  Liu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Resveratrol 100%
  • Activating Transcription Factor 3 81%
  • Doxorubicin 63%
  • Cardiac Myocytes 47%
  • Activating Transcription Factors 25%

• Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

  Hwang, L.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orexins 100%
  • Orexin Receptors 97%
  • Inbred SHR Rats 57%
  • Hypertension 30%
  • Arterial Pressure 23%

• Statin Inhibits Pressured-Induced Rat Renal Tubular Cell Apoptosis and Tubulointerstitial Fibrosis

  Chen, T. & Chen, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 100%
  • Peroxisome Proliferator-Activated Receptors 49%
  • Pressure 46%
  • Kidney 44%
  • Nephrosis 29%

• Circadian Rhythm as a Mediator between Sleep Disturbances and Pain Intensity and Its Prognostic Role in Predicting Survival in Advanced Cancer Patients

  Lin, C., Hu, C. & Lai, Y.

  8/1/10 → 10/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Pain 74%
  • Cancer Pain 61%
  • Circadian Rhythm 54%
  • Neoplasms 49%

• Expression of Deptor Gene and Its Effect on the Early Development of Liver and Gut in Zebrafish

  Cheng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • digestive system 100%
  • Danio rerio 84%
  • liver 72%
  • rapamycin 53%
  • immunohistochemistry 41%

• Investigation of a Novel Peptide-Nanoformulation as Eyedrop with Nox2 Inhibition Capacity for Prevent Sight-Threatening Blood Vessel Growth on the Surface of the Eye

  Tseng, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 改質活性碳添加於新型微管陣列薄膜應用於中分子蛋白質吸附之高效率 血液淨化器研究

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明動力素分子馬達蛋白質(kinesin molecular motor protein) 之關節區團 （hinge domain）的結構和功能—為建構實用的動力素分子載具鋪路

  Kuo, T.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anxiety, Depression and Coronary Spasm: a Synthesis of Epidemiological and Experimental Studies

  Hung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Spasm 100%
  • Coronary Vessels 78%
  • Anxiety 22%
  • Coronary Artery Disease 22%
  • Depression 17%

• Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder and High Level of Inflammation：A Pilot Study of 8-Week Open Trail

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lactobacillus plantarum 100%
  • Gastrointestinal Microbiome 89%
  • Inflammation 84%
  • Probiotics 77%
  • Permeability 62%

• Translational Relevance and Mechanism of Glucose Transporter 3 in Colon Cancer Metastasis: Focus on Tumor Microenvironment and Developing Therapeutics

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 洗腎患者使用非類固醇抗發炎藥物與手術後併發症之相關性

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C., Tsai, P., Liu, H., Lin, Y. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M., Chen, Y. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• The Causes and Courses of Insomnia---Case-Control and Follow-up Study

  Lee, H., Hsu, R. & Kang, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep Initiation and Maintenance Disorders 100%
  • Sleep 24%
  • Organized Financing 18%
  • Arousal 15%
  • Case-Control Studies 12%

• The Alteration of Inflammatory Reflex and Its Association with Psychotropic Drugs in Bipolar Disorder from Acute Mania to Full Remission

  Tsai, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bipolar Disorder 100%
  • Reflex 82%
  • Cholinergic Agents 32%
  • Psychological Power 21%
  • Antipsychotic Agents 21%

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications

  Chen, L. & Wu, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 19%
  • Occurrence in Nature 17%
  • Pharmacological Metabolism 11%
  • Biological Role 8%