College of Medicine

Projects

Projects per year 2010 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2026

• 2 Not started
• 113 Active
• 2906 Finished

Projects per year

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• 探討黃腐醇合併降血糖藥是否可調控粒線體失常並經由活化未摺疊蛋白反應所激發之AMPK-NRf2-ARE-Glo1路徑來逆轉雙羰基壓力導致之糖尿病腎脂毒性

  Chen, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 絲氨酸/蘇氨酸蛋白激酶(SIK3)參與乳癌致癌過程的分子機制探討

  Chen, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高氧誘導的肺損傷由新生小鼠的肺和腸道微生物群相介導

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討在慢性腎臟疾病中經由抑制內皮素轉化酶調節前列腺素E2受體和自體吞噬作用的治療潛力之機轉(1/3)

  Lin, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 葡萄糖轉運接受器促進大腸癌轉移之臨床轉譯價值與機制探討:著重在腫瘤微環境研究及治療藥物之開發(3/3)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 英明格引發呼吸道過度敏感:肺C纖維的角色(3/3)

  Lin, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討檜木醇治療缺血再灌注之肝損傷的新策略(2/3)

  Chen, R.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具機械強度、可降解及骨誘導能力之鎂基非晶質合金應用於高位脛骨截骨矯正術之骨填充楔開發(1/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 益生菌PS128對重鬱症患者之生理及憂鬱症狀影響：八周之隨機,雙盲,安慰劑控制試驗

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 麻醉護理專業證照及進階制度之臨床能力架構與評量—客觀結構式臨床測驗(OSCE)與可信賴專業活動(EPA)等工具之建構與驗證研究(1/2)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討芳香烴受體核轉位蛋白受器/丙酮酸去氫激酶1路徑在與化療相關的頭頸癌進展所扮演的角色(1/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討脯氨酸循環調控癌細胞代謝重組與腸道菌群在胰腺癌吉西他濱抗藥性中的作用

  Huang, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-探討α9尼古丁受體基因表現在乳癌病人血液循環腫瘤細胞/游離DNA於乳癌治療的應用(1/3)

  Tzeng, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 遠紅外線改善線粒體功能對糖尿病小鼠胰島β細胞的保護作用及與SIRT1和PLZF相關機制的研究(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以循環腫瘤細胞預測肝癌治療反應及其機制探討

  Chiou, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 膠淋巴系統於混合型失智症之角色(1/2)

  Hu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討多環芳香烴受體缺陷重啟多能細胞特性之新穎路徑與應用

  Li, C.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 寡糖經由調節發炎反應來保護急性腎損傷的機制研究

  Chen, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 血管內皮β-catenin活化於動靜脈廔管狹窄之角色

  Sue, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 同時抗碳青黴烯類和抗粘菌素的不動桿菌屬菌株之特性分析：抗藥機轉、毒力及適應力

  Huang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-節拍式化學治療增進基質硬化性胰臟癌免疫監督與免疫檢查點阻斷療法: 聚焦於腫瘤基質與髓源性抑制細胞(2/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樹突細胞PD-L1/PD-L2失調在COPD 異常發炎的角色及機制探討(2/3)

  Lee, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討PINK1於肺癌代謝鏈的調控機轉並研發可以調控PINK1活性的藥物(3/3)

  Lin, E. P.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討生物時鐘所調控之新型態肝細胞分裂模式在肝臟生理功能及相關疾病中所扮演之角色(3/3)

  Chao, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辛伐他汀抗腎細胞癌的作用，經由抑制代謝重編程從mTOR、PPAR到RhoA(2/3)

  Juan, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析：以雙面向方法發展對抗沙門氏菌感染之新策略(2/3)

  Fang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用轉錄體學與蛋白質體學方法探討膀胱癌對鉑類藥物產生抗藥性之分子機轉研究並開發新的治療策略(第二年)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由調控神經包網結構來改善早期社交孤立所誘發於模棱兩可的資訊下異常恐懼記憶連結的形成(1/3)

  Yang, C. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫三：運用跨模態多項次神經影像技術探討神經調控模式對脊髓損傷者之神經可塑性與功能變化(2/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 助孕酮受器在葉酸抑制腫瘤細胞生長及轉移所扮演的角色(3/3)

  Lee, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ZFHX3 knockdown調控心房纖維化導致心房顫動病理性結構重塑之機轉探討

  Kao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 創新電漿活化水製備表面增強拉曼散射活性基材(2/3)

  Liu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以新式片狀細胞工學製備自體片狀心肌細胞及其應用在缺血性心臟病的動物模式

  Tseng, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發具有骨誘導性之溫感性水膠包埋凍乾型富含血小板纖維蛋白並結合人工代用骨複合型材料用於兔子臨界骨缺損之修補(1/3)

  Wong, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 潛在臨終個案篩檢計分系統：應用死亡風險預測與機器學習於心臟衰竭與慢性腎臟衰竭患者之安寧療護需求評估

  Chang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 丙型干擾素抗性於上皮細胞間質轉化對免疫檢查點阻斷療法的影響

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(1/3)

  Lin, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• anti-EGFR×anti-FAP雙辨識特異性抗體結合包覆抗癌藥物Irinotecan標靶微脂體治療胰臟癌之研究(3/3)

  Lin, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發尼古丁乙醯膽鹼受體亞型5之單鏈變異片段型抗體及評估此一抗體對於增強口腔癌之放射線敏感度的治療效果

  Lin, C.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明SPOCK1/PI3K/AKT訊息路徑在透明細胞腎細胞癌對舒尼替尼抗藥性的潛在機制

  Lee, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 纖維細胞生長因子與其受體之訊息路徑在急性腎損傷中維持腎臟血管結構能力之角色研究

  Cheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合神經影像及蛋白質體學的纖維肌痛症者的縱向分析(2/2)

  Kang, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立類神經網路模型以評估手術病患發生呼吸中止與低血氧的風險

  Chang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立傳染疾病的全球傳播風險預警架構：評估台灣與東亞區域的境外移入風險(2/2)

  Chuang, T.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 調控半乳糖凝集素之免疫訊號重整作用對心房再塑與心律不整活性的病理機轉探討：一個新的治療心房顫動契機(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色: 調控T細胞的效應及逆轉賀癌平抗藥性的分子機制(2/3)

  Chao, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:動物模式與人類世代之整合研究-青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:健康青少年族群之觀察追蹤與介入研究(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 吳茱萸生物鹼rutaecarpine調控血小板活化及自噬作用的機轉探討以及在自體血栓塊引起腦中風鼠的活性評估: NF-kB在無核細胞中的角色(2/3)

  Sheu, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 環境酸化對魚類側線感覺毛細胞的傷害機制

  Horng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討第一型內皮細胞分子與上皮細胞生長因子受體之相互調控在非小細胞肺癌進程之角色(3/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology