Projects per year
- 700 - 750 out of 3,004 results
Search results
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Role of ER Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting
Tzao, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effect of Vasopressin Receptor Agonist and Antagonist on Pulmonary Vein and Atrial Arrhythmogenesis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (II)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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ALA Photodynamic Therapy, Tumor Hypoxia, CSE1L Phosphorylation, and the Progression and Treatment of Skin Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study
Chen, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma---The Treatment of Metastatic Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Influence of Porphyromonas gingivalis Groel in Vascular Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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探討不同選擇作用之組織蛋白去乙醯?調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Mechanisms of PARP-1 in Regulating NLRP3 Inflammasome Activation
Lin, W.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Haplo-Insufficiency of TSGs on Chromosome 2 for Paclitaxel-Resistant Phenotype of OCCA Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Developing Human Intestinal in vitro Organ Culture and an in vitro M-Cell Model as Platforms for Investigation of Novel Oral Vaccines
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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肝醣合成酉每激酉每3於登革病毒感染單核吞噬細胞的潛在角色(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Association Study of Persistent Metabolic Syndrome, Inflammatory Markers, Adipose Markers and Mild Cognitive Decline
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression---An Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs
Wang, L.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Arsenic Methylation Capacity, Methylenetetrahydrofolate Reductase and Dna Methylation Gene Polymorphisms, Plasma Selenium Concentration and Selenoprotein Gene Polymorphisms and Renal Cell Carcinoma
Hsueh, Y.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Highly Reliable Surface-Enhanced Raman Scattering Sensors
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models
Hwang, J.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Unraveling the Impact of Deletion of Androgen Receptor on Brain Trauma
Yang, L.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of Clinical Feasibility of Quantitative MR Perfusion Imaging and Its Calibration
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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腫瘤相關巨噬細胞在誘發產生表皮生長因子受器酪胺酸酉每抑制劑的抗藥性的角色
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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組蛋白去甲基酉每JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Adipose-Derived Stem Cells on Denervated Rat Skeletal Muscle Atrophy
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.
Ho, Y. & Wu, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Serum Free Cultivation of Multi-Layered Oral Mucosa Epithelial Cell Sheet for Autologous Corneal Epithelium Repairing and Its Animal Model
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Explore the Molecular Mechanisms and Application of microRNA-16 in In Acute Kidney Injury
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology