College of Medical Science and Technology

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1993 2020

Clinical trials of new drugs for Alzheimer disease

Huang, L. K., Chao, S. P. & Hu, C. J., Jan 6 2020, In : Journal of Biomedical Science. 27, 1, 18.

Research output: Contribution to journalReview article

Open Access
Open Access
Publications
Hepatocellular Carcinoma
Interleukin-6
Research
Neoplasms
1 Citation (Scopus)

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, e12620.

Research output: Contribution to journalArticle

Leiomyoma
Melatonin
Cell Death
Cell Proliferation
Myometrium
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

NDAT suppresses pro-inflammatory gene expression to enhance resveratrol-induced anti-proliferation in oral cancer cells

Ho, Y., Wu, C. Y., Chin, Y. T., Li, Z. L., Pan, Y. S., Huang, T. Y., Su, P. Y., Lee, S. Y., Crawford, D. R., Su, K. W., Chiu, H. C., Shih, Y. J., Changou, C. A., Yang, Y. C. S. H., Whang-Peng, J., Chen, Y. R., Lin, H. Y., Mousa, S. A., Davis, P. J. & Wang, K., Feb 2020, In : Food and Chemical Toxicology. 136, 111092.

Research output: Contribution to journalArticle

Mouth Neoplasms
resveratrol
Gene expression
Cells
Gene Expression
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 Citation (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

Integrins
Thyronines
Thyroid Hormone Receptors
Neoplasms
Glioblastoma

Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade

Dubey, N. K., Wei, H-J., Yu, S. H., Williams, D. F., Wang, J. R., Deng, Y. H., Tsai, F. C., Wang, D. P. & Deng, W-P., 2019, In : Aging and Disease.

Research output: Contribution to journalArticle

Osteoarthritis
Stem Cells
Knee Joint
Advanced Glycosylation End Products
NF-kappa B

Adverse Outcomes after Major Surgeries in Patients with Diabetes: A Multicenter Matched Study

Lin, C-S., Chang, C-C., Lee, Y-W., Liu, C-C., Yeh, C-C., Chang, Y-C., Chuang, M-T., Chang, T-H., Chen, T-L. & Liao, C-C., Jan 16 2019, In : Journal of Clinical Medicine. 8, 1

Research output: Contribution to journalArticle

Multicenter Studies
Odds Ratio
Confidence Intervals
Hospital Mortality
Necrotizing Fasciitis

A genome-centric approach reveals a novel glycosyltransferase from the ga a07 strain of bacillus thuringiensis responsible for catalyzing 15-o-glycosylation of ganoderic acid a

Chang, T. S., Wang, T. Y., Hsueh, T. Y., Lee, Y. W., Chuang, H. M., Cai, W. X., Wu, J. Y., Chiang, C. M. & Wu, Y. W., Oct 2 2019, In : International Journal of Molecular Sciences. 20, 20, 5192.

Research output: Contribution to journalArticle

Open Access
Glycosylation
Glycosyltransferases
Bacillus thuringiensis
genome
Bacillus
1 Citation (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract-based automatic analysis

Lo, Y. C., Chen, Y. J., Hsu, Y. C., Chien, Y. L., Gau, S. S. F. & Tseng, W. Y. I., 2019, In : Autism Research.

Research output: Contribution to journalArticle

Siblings
Anisotropy
Communication
Phenotype
Diffusion Magnetic Resonance Imaging
Adipogenesis
Protein Isoforms
White Adipocytes
Brown Adipose Tissue
3T3-L1 Cells

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis
2 Citations (Scopus)

A machine learning approach for predicting urine output after fluid administration

Lin, P. C., Huang, H. C., Komorowski, M., Lin, W. K., Chang, C. M., Chen, K. T., Li, Y. C. & Lin, M. C., Aug 1 2019, In : Computer Methods and Programs in Biomedicine. 177, p. 155-159 5 p.

Research output: Contribution to journalArticle

Learning systems
Oliguria
Urine
Sepsis
Fluids
1 Citation (Scopus)
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
polyhydroxybutyrate
Multigene Family
multigene family
Glycerol

An artificial intelligence approach to early predict non-ST-elevation myocardial infarction patients with chest pain

Wu, C. C., Hsu, W. D., Islam, M. M., Poly, T. N., Yang, H. C., Nguyen, P. AA., Wang, Y. C. & Li, Y. CJ., May 1 2019, In : Computer Methods and Programs in Biomedicine. 173, p. 109-117 9 p.

Research output: Contribution to journalArticle

Artificial Intelligence
Chest Pain
Artificial intelligence
Neural networks
Neural Networks (Computer)

An Assessment of the Interoperability of Electronic Health Record Exchanges Among Hospitals and Clinics in Taiwan

Wen, H-C., Chang, W-P., Hsu, M-H., Ho, C-H. & Chu, C. M., Mar 28 2019, In : JMIR medical informatics. 7, 1, p. e12630

Research output: Contribution to journalArticle

Electronic Health Records
Taiwan
National Health Programs
Medical Records
Outpatients
4 Citations (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Androgens
Prostatic Neoplasms
Cyclooxygenase Inhibitors
Androgen Receptors

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., Nov 1 2019, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Radiation Tolerance
Autophagy
Proteins

A new triterpenoid glucoside from a novel acidic glycosylation of ganoderic acid a via recombinant glycosyltransferase of bacillus subtilis

Chang, T. S., Chiang, C. M., Kao, Y. H., Wu, J. Y., Wu, Y. W. & Wang, T. Y., Sep 24 2019, In : Molecules. 24, 19, 3457.

Research output: Contribution to journalArticle

Open Access
Glycosylation
Glycosyltransferases
glucosides
Bacillus
Glucosides
2 Citations (Scopus)
Open Access
Electronic Health Records
Human Influenza
Incidence
Taiwan
Centers for Disease Control and Prevention (U.S.)
Open Access
temozolomide
Glioblastoma
Phenotype
Glioma
Stem Cells
Castration
Autophagy
Prostatic Neoplasms
Cell Death
Osteogenesis
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins
1 Citation (Scopus)

Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02

Ho, Y. J., Lu, J. W., Ho, L. J., Lai, J. H., Huang, H. S., Lee, C. C., Lin, T. Y., Lien, S. B., Lin, L. C., Chen, L. W., Gong, Z., Shen, M. C. & Liu, F. C., Sep 10 2019, In : Biochemical and Biophysical Research Communications. 517, 1, p. 155-163 9 p.

Research output: Contribution to journalArticle

Cartilage
Osteoarthritis
Chondrocytes
Anti-Inflammatory Agents
Chemical activation
5 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
1 Citation (Scopus)

Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Chen, J. H., T.H Wu, A., T.W Tzeng, D., Huang, C. C., Tzeng, Y. M. & Chao, T. Y., Jan 1 2019, In : Phytomedicine. 52, p. 70-78 9 p.

Research output: Contribution to journalArticle

Antrodia
Catenins
Carcinogenesis
Breast
Down-Regulation
1 Citation (Scopus)

Antrodia cinnamomea enhances chemo-sensitivity of 5-fu and suppresses colon tumorigenesis and cancer stemness via up-regulation of tumor suppressor miR-142-3p

Huang, Y. J., Yadav, V. K., Srivastava, P., Wu, A. T. H., Huynh, T. T., Wei, P. L., Huang, C. Y. F. & Huang, T. H., Aug 1 2019, In : Biomolecules. 9, 8, 306.

Research output: Contribution to journalArticle

Open Access
Antrodia
Fluorouracil
Colonic Neoplasms
Tumors
Carcinogenesis

A positive legacy of trauma? A study on the impact of natural disasters on medical utilization

Iqbal, U., Li, Y-C. J., Tang, K-P., Chien, H-C., Yang, Y-T. & Hsu, Y-H. E., Feb 1 2019, In : International Journal for Quality in Health Care. 31, 1, p. 64-69 6 p.

Research output: Contribution to journalReview article

Earthquakes
Disasters
Survivors
Wounds and Injuries
Outpatients

A probabilistic model for reducing medication errors: A sensitivity analysis using Electronic Health Records data

Huang, C. Y., Nguyen, P. A., Yang, H. C., Islam, M. M., Liang, C. W., Lee, F. P. & (Jack) Li, Y. C., Mar 1 2019, In : Computer Methods and Programs in Biomedicine. 170, p. 31-38 8 p.

Research output: Contribution to journalArticle

Medication Errors
Electronic Health Records
Statistical Models
Sensitivity analysis
Prescriptions

Aspirin better than clopidogrel on major adverse cardiovascular events reduction after ischemic stroke: A retrospective nationwide cohort study

Vidyanti, A. N., Chan, L., Lin, C. L., Muo, C. H., Hsu, C. Y., Chen, Y. C., Wu, D. & Hu, C. J., Jan 1 2019, In : PLoS ONE. 14, 8, e0221750.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
Skin Neoplasms
ROC Curve
Medical Records
Learning
Trazodone
Open Access
Acid Sensing Ion Channels
Brain Concussion
Dizziness
Alleles
Genes

Association Between Atrial Fibrillation and Dementia: A Meta-Analysis

Islam, M. M., Poly, T. N., Walther, B. A., Yang, H. C., Wu, C. C., Lin, M. C., Chien, S. C. & Li, Y. C., Nov 8 2019, In : Frontiers in Aging Neuroscience. 11, 305.

Research output: Contribution to journalReview article

Open Access
Atrial Fibrillation
Dementia
Meta-Analysis
Publication Bias
Social Adjustment
1 Citation (Scopus)

Association between gout and cardiovascular disease risk: A nation-wide case-control study

Liang, C-W., Islam, M. M., Poly, T. N., Yang, H-C. & Jack Li, Y-C., May 2019, In : Joint Bone Spine.

Research output: Contribution to journalArticle

Association Between Psoriasis and Dementia: A Population-Based Case-Control Study

Lin, C-C., Lin, H-C. & Chiu, H-W., Jun 1 2019, In : American Journal of Clinical Dermatology. 20, 3, p. 457-463 7 p.

Research output: Contribution to journalArticle

Psoriasis
Dementia
Case-Control Studies
Population
Bullous Pemphigoid
1 Citation (Scopus)

Association between Use of Statin and Risk of Dementia: A Meta-Analysis of Observational Studies

Poly, T. N., Islam, M. M., Walther, B. A., Yang, H. C., Wu, C. C., Lin, M. C. & Li, Y. C., Jan 1 2019, (Accepted/In press) In : Neuroepidemiology.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Observational Studies
Dementia
Meta-Analysis
Odds Ratio
2 Citations (Scopus)

Association of chronic hepatitis B virus infection with age-related macular degeneration

Wu, C. M., Su, F. H., Wang, W. C., Lin, C. P., Kamiza, A. B., Chang, S. N. & Yeh, C. C., Jan 1 2019, In : Acta Ophthalmologica.

Research output: Contribution to journalArticle

Chronic Hepatitis B
Macular Degeneration
Virus Diseases
Hepatitis B virus
Cercopithecine Herpesvirus 1

Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk

Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W. & Bau, D. T., Jan 1 2019, In : Anticancer Research. 39, 12, p. 6523-6529 7 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Colorectal Neoplasms
Genotype
Neoplasm Metastasis
Age Distribution
2 Citations (Scopus)
Open Access
Astragalus
dendritic cells
lung neoplasms
Dendritic Cells
Polysaccharides
AMP-Activated Protein Kinases
Epithelial-Mesenchymal Transition
Hypoxia-Inducible Factor 1
Colonic Neoplasms
Colorectal Neoplasms
Open Access
Cyclin D
Cell Proliferation
Medicine
Internal Medicine
Taiwan

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

Chen, F. Y., Huang, M. Y., Lin, Y. M., Ho, C. H., Lin, S. Y., Chen, H. Y., Hung, M. C. & Chen, R. H., Sep 2 2019, In : The Journal of cell biology. 218, 9, p. 3002-3018 17 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Ubiquitination
Unfolded Protein Response
Apoptosis Regulatory Proteins
Proteasome Endopeptidase Complex