College of Medical Science and Technology

Projects

Projects per year 2010 2022

• 37 Active
• 810 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  探討長鏈非編碼RNA LncHIFCAR-HIF1A 基因調控網路及其於口腔癌進程之臨床價值(2/2)

  Shih, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對PD-L1 表現機制所發展出之口腔癌治療策略(2/3)

  Lin, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • adipose tissue 84%
  • insulin receptors 78%
  • adipogenesis 75%
  • energy 49%

• 亨丁頓關聯蛋白與阿伯爾森幫手整合位點蛋白的交互作用在乙型類澱粉引起的神經退化中之角色

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs

  Pan, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Germline Dna Repair Gene Mutations in Advanced Prostate Cancer

  Shao, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討新穎表觀遺傳調控作為缺氧性口腔癌標靶-探討LncRNA-KDM4 axis在缺氧性口腔癌之角色(2/3)

  Kung, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Pathogenic Role of Posttranslational Modification of Plasma N-Linked Glycoprotein to Rheumatoid Arthritis Combined Sjogren$S Syndrome Was Investigated

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sjogren's Syndrome 100%
  • Rheumatoid Arthritis 73%
  • Post Translational Protein Processing 62%
  • Blood Proteins 19%
  • Proteins 14%

• 以機器學習辨識兒童注意力不足及注意力不足過動症

  Chiu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討胺基酸代謝基因標誌及其在雌激素高表達乳癌病人之治療機制(2/2)

  Wang, C.

  1/1/21 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 100%
  • Metabolic Networks and Pathways 49%
  • Pancreatic Neoplasms 46%
  • Knockout Mice 45%
  • Insulin Resistance 40%

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • neoplasms 100%
  • neoplasm cells 59%
  • Biological Sciences 47%
  • cancer therapy 31%
  • drug development 27%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 100%
  • Metabolic Networks and Pathways 49%
  • Pancreatic Neoplasms 46%
  • Knockout Mice 45%
  • Insulin Resistance 40%

• Study and Implementation of Patient Privacy Protection under the Framework for Electronic Medical Records Exchange in Taiwan

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electronic medical equipment 100%
  • Data privacy 38%
  • Health insurance 14%
  • Health 13%
  • Virtual private networks 13%

• Dysregulation of Huntingtin-Associated Protein-Mediated Calcium Trafficking in Neurodegenerative Diseases

  Lin, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proto-Oncogene Proteins c-bcr 100%
  • Proteins 89%
  • Huntingtin Protein 71%
  • Neurodegenerative Diseases 63%
  • Kinesin 62%

• Investigation of Molecular Mechanisms Governing Cancer Exosomes-Orchestrated Tumor-Host Interaction during Disease Progression.

  Hwang, W.

  2/1/16 → 1/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms and Therapeutic Strategies of Pd-L1 Expression in Oral Cancers( I )(1/3)

  Lin, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• G蛋白偶聯雌激素受體在EGFR突變之肺腺癌細胞中扮演的角色

  Kao, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Mechanistic Action of DDX3 in Colorectal Tumor Progression

  Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • beta Catenin 100%
  • Catenins 46%
  • Drug Resistance 45%
  • Neoplasms 43%
  • Colorectal Neoplasms 39%

• Carbamylation Modification of Novel Synovial Fluid and Serum Proteins and Its Role of Anti-Carbanylated Protein Autoantibodies in the Clinic Association of Rheumatoid Arthritis Was Investigated

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rheumatoid Arthritis 100%
  • Protein Carbamylation 74%
  • Synovial Fluid 68%
  • Proteins 44%
  • Autoantibodies 41%

• 嘌呤類似物對阿茲海默症模型小鼠的療效評估

  Lin, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Galectin-1 in Liver Fibrosis-Promoted Stem-Like Cell Properties and Sorafenib-Refractoriness of Hbv-Related Hepatocellular Carcinoma( III )

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structure-Based Design, Synthesis and Biological Evaluation of Novel 6-Substituted 10-Chloro-12h-Thiochromeno[2,3-C]Quinolin-12-One Derivatives as Potential Anticancer Agents

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antineoplastic Agent 100%
  • Intoplicine 80%
  • Molecule 65%
  • Topoisomerase Inhibitor 63%
  • Growth Inhibition 44%

• Human Anti-Citrullinated Inter-Alpha-Trypsin Inhibitor Heavy Chain H3 Peptide Antibody Elisa Kit : in Vi Tro Diagnostics Kit of Autoimmune Rheumatic Diseases Examination

  Lin, C.

  11/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rheumatoid Arthritis 100%
  • Peptides 38%
  • inter-alpha-inhibitor 32%
  • Anti-Citrullinated Protein Antibodies 27%
  • Autoantibodies 27%

• Impact of Electron-Transfer-Flavoprotein Dehydrogenase Mutation on Bioenergetic Metabolism and Muscular Differentiation in Vitro

  Kao, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency 100%
  • Electron-Transferring Flavoproteins 89%
  • Mutation 24%
  • Energy Metabolism 19%
  • Fatty Acids 18%

• Fragment-Based Discovery of First-In-Class Small-Molecule Kinase Inhibitors for Targeted Cancer Therapies(2/2)

  Huang, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Crowdhealth Project: Using Health-Related Big Data for Supporting Policy Making Decisions

  Shabbir, S. A.

  4/1/19 → 3/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Industry-University Alliance on Pilot-Type Animal Experimental Consultancy and Analytic Platforms(3/3)

  Chang, H.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

  Deng, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • Light 81%
  • Bone Regeneration 64%
  • Inflammation 47%
  • Alveolar Bone Loss 46%

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 17%
  • Autophagic Cell Death 16%
  • Unfolded Protein Response 13%

• Molecular Ivestigation of the Electron Transfer Flavoprotein Dehydrogenase Mutation Induced Mitochondrial Dysfunction and Metabolic Defects

  Kao, S. & Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • acyl-CoA dehydrogenase 100%
  • flavoproteins 97%
  • electron transfer 79%
  • droplets 39%
  • myoblasts 31%

• Investigation for the Molecular Mechanism Involved in the Expression and Impact of Alternatively-Spliced Srsf3 and Map4k4 Variants on Brown Adipogenesis

  Lin, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • serine 100%
  • arginine 95%
  • adipogenesis 82%
  • brown adipose tissue 72%
  • alternative splicing 55%

• 動物冠狀病毒抗體開發-抗豬流行性下痢病毒蛋白的抗體製備與定性

  Yang, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以深度學習分析臨床特徵及胚胎品質以提升人工受孕懷孕率之系統性預測方法開發

  Su, E. C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • beta Catenin 90%
  • Lung Neoplasms 58%
  • Carcinogenesis 56%
  • Lung 55%

• Occupation Choices, Work Characteristics, and Career Success of Medical Technology Undergraduates from Gender and Generational Perspectives (K01)

  Liang, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medical technology 100%
  • bachelor 44%
  • graduate 29%
  • gender role 22%
  • Taiwan 19%

• A Tmu/Nih Integrated Research Project (4-3)─ Establishment of Image Diagnosis of Mild Traumatic Brain Injury by Functional Neuroimaging

  Chen, C. & Chiang, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 16%
  • N-nitrosoiminodiacetic acid 14%
  • Taiwan 8%
  • Wounds and Injuries 7%
  • Animal Models 7%

• A Tmu/Nih Integrated Research Project (4-2)─ Establishment of Diagnostic Tools and Treatment Strategies of Mild Traumatic Brain Injury

  Chiu, W., Chiang, Y. & Hung, K.

  8/1/11 → 9/5/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • N-nitrosoiminodiacetic acid 18%
  • Animal Models 15%
  • Taiwan 10%
  • Postural Balance 8%
  • Population 8%

• Genomic, Epigenomic and Epiproteomic Analysis of Etk/Bmx Traumatic Brain Injury

  Chen, K., Chiang, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Protein Kinases 15%
  • Epigenomics 14%
  • Tec protein-tyrosine kinase 14%
  • Inflammation Mediators 10%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of multitarget inhibitors for colorectal cancer treatment using Pharmalogs

  Hsu, K. & Cheng, Y.

  2/1/16 → 1/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Selective Inhibitors for Oncoprotein Kinases

  Hsu, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Protein Kinases 100%
  • Phosphotransferases 92%
  • Oncogene Proteins 72%
  • Pharmaceutical Preparations 35%
  • Neoplasms 24%

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus( I )

  Hsu, K.

  8/1/17 → 7/1/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery and Design of Kinase Inhibitors for Cancer Treatment

  Hsu, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug 100%
  • 50 Percent Growth Inhibition 63%
  • Disorder 40%
  • Protein 39%
  • Oncogenic 33%

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus(3/3)

  Hsu, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立新興環境汙染物與藥物毒理預測平台之研究

  Hsu, K.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Toxicity of Chitosan Nanowaste in Freshwater Fishes: Establishment of Toxicity Assessment Platform for Nanomaterials

  Cheng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%