College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 72 Active
• 997 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  Gene Signatures and Potential Therapeutic Targets of Amino Acid Metabolism in Estrogen Receptor-Positive Breast Cancer(1/2)

  Wang, C.

  1/1/20 → 12/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anoikis 60%
  • Breast Neoplasms 60%
  • Amino Acids 58%
  • TOR Serine-Threonine Kinases 34%
  • tamoxifen acid 21%

• Huntingtin-Associated Protein-Mediated Vesicular Trafficking Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alzheimer Disease 100%
  • Microtubules 83%
  • Neurodegenerative Diseases 74%
  • Biomarkers 69%
  • Huntingtin Protein 62%

• Investigation of the Novel Role and Underlying Mechanism of Znf179 in Synaptic Trafficking

  Lee, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Zinc Fingers 100%
  • Proteins 45%
  • Endosomes 15%
  • Exocytosis 15%
  • Ubiquitination 14%

• TDP-43蛋白在神經細胞中功能及在神經退化疾病上角色的基礎與轉譯研究(3/3)

  Shen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function

  Tzeng, C., Hsieh, R. & Kao, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • hormone agonists 100%
  • mitochondria 91%
  • pathophysiology 42%
  • granulosa cells 38%
  • agonists 32%

• TDP-43蛋白在神經細胞中功能及在神經退化疾病上角色的基礎與轉譯研究(2/3)

  Shen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 尋找藥物結構、菌種特性與MIC distribution的關聯與預測模型

  Wu, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 噬菌體展現技術製備之辨識蛇毒蛋白的雞源單鏈抗體之分析與人源化研究

  Yang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制site-1蛋白酶引發肝癌細胞自我吞噬之研究

  Yang, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Astrocytic Cebpd-Regulated Mirnas and Their Effects on Angiogenesis during Neuroinflammation

  Ko, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alzheimer Disease 100%
  • MicroRNAs 77%
  • Astrocytes 67%
  • Angiogenesis Inducing Agents 41%
  • Endothelial Cells 40%

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antibodies 100%
  • Single-Chain Antibodies 93%
  • Anti-Idiotypic Antibodies 60%
  • Diphosphates 47%
  • human RRM2B protein 46%

• 脂質薑黃素顆粒(SLCP)在體內對mTOR訊息路徑的作用–尋求以疾病機制為基礎對結節性硬化症(TSC)癲癇的治療策略(1/3)

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• Neurodegenerative Diseases( I )(1/3)

  Shen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y., Wu, C. & Lee, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%

• Potential Therapeutic Effect of Curcumin, a Natural Mtor Inhibitor, in Tuberous Sclerosis Complex

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Curcumin 100%
  • Tuberous Sclerosis 99%
  • TOR Serine-Threonine Kinases 65%
  • Raptors 22%
  • Knockout Mice 20%

• 利用基因網絡分析尋找假定蛋白質 （hypothetical protein)與抗藥性的關係

  Wu, Y.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 運用機器學習演算法透過基因體資訊挖掘未知基因的功能與預測細菌抗藥性(2/3)

  Wu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multi-Omics Approach for Interpreting the Functional Potentials of Uncharacterized Bacteria in Natural or Man-Made Environments

  Wu, Y.

  3/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • organism 100%
  • genome 91%
  • environmental study 55%
  • genomics 48%
  • twenty first century 45%

• 以白色念珠菌 alpha-enolase 為目標的單株抗體的人源化與其可能的應用

  Yang, Y.

  2/1/17 → 1/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討miR-21調控大腸直腸癌細胞TET1/5-hydroxymethylcytosine表現對其化療反應之關聯(3/3)

  Yang, P.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Effect of the Recombinant OmpA Protein Fragments Protect Mice from Death Caused by E. coli Induced Bacteremia

  Wu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • OMPA outer membrane proteins 100%
  • Escherichia coli Infections 70%
  • Escherichia coli 29%
  • Proteins 17%
  • Leukocytes 16%

• 探討新型benzimidazole衍生物抑制肝癌抗藥性細胞生長的角色

  Liao, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 人工智能技術應用於新穎胰臟癌藥物研發與優化(1/2)

  Hsu, K.

  11/1/21 → 10/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用基因網絡分析尋找假定蛋白質 （hypothetical protein)與抗藥性的關係

  Wu, Y.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Selective Inhibitors for Oncoprotein Kinases

  Hsu, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Protein Kinases 100%
  • Phosphotransferases 92%
  • Oncogene Proteins 72%
  • Pharmaceutical Preparations 35%
  • Neoplasms 24%

• Design and Potency Optimization of Kinase Inhibitors for Cancer Treatment(1/3)

  Hsu, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Role of Niemann-Pick Type C2 Protein in the Inhibition of Hscs Activation and Liver Fibrosis Treatment

  Liao, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Liver Cirrhosis 100%
  • Cholesterol 39%
  • Becaplermin 35%
  • Fibrosis 13%
  • Fetal Proteins 12%

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  1/1/13 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 46%
  • Cholesterol 45%
  • Mitogen-Activated Protein Kinase 1 34%
  • Liver 32%

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 46%
  • Cholesterol 45%
  • Mitogen-Activated Protein Kinase 1 34%
  • Liver 32%

• 建構阿茲海默氏症細胞藥物篩選模式：分析小分子藥物488和電漿活化水抑制類澱粉斑塊的形成

  Cheng, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Role of Niemann-Pick Type C2 Protein in Liver Cancer

  Liao, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 70%
  • Carcinogenesis 40%
  • Cholesterol 39%
  • Liver 36%

• Study the Toxicity of Chitosan Nanowaste in Freshwater Fishes: Establishment of Toxicity Assessment Platform for Nanomaterials

  Cheng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立新興環境汙染物與藥物毒理預測平台之研究

  Hsu, K.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C., Tsai, P., Liu, H., Lin, Y. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer( III )

  Lee, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• Investigation the Molecular Mechanism of Long Non-Coding Rna-Crnde-Regulated Gene Expression and Identification Inhibitors for Crnde or for Molecules Involved Crnde-Regulated Signaling in Colorectal Cancer Cells

  Lee, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • APC Genes 58%
  • Neoplasms 45%
  • Polycomb Repressive Complex 2 42%
  • Ciclopirox 22%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care

  Hu, S. H., Li, Y., Sheu, S. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medication 100%
  • ambulatory care 45%
  • pharmacist 40%
  • reconciliation 39%
  • physician 33%

• To Study the Role of Sp1 in Cancer Drug Resistance( I )

  Chuang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug Resistance 100%
  • Temozolomide 84%
  • Neoplasms 48%
  • superoxide dismutase 2 40%
  • Reactive Oxygen Species 32%

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • neoplasms 100%
  • neoplasm cells 59%
  • Biological Sciences 47%
  • cancer therapy 31%
  • drug development 27%

• Roles of Microrna96 in Tgfβ-Mediated Tumor Progression

  Tsai, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• Genetic Polymorphisms in Hypoxia Inducible Factor-1 and Inflammation Pathway Related microRNA and Its Target Genes and Risk of Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y., Cho, E., Chi, N. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Hyperglycemia 79%
  • Stroke 64%
  • Inflammation 37%
  • Biomarkers 10%

• MCPIPs鋅指蛋白家族在人類大腸直腸癌組織的表現及調控Akt訊息傳遞路徑之研究

  Liang, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Mechanisms and Therapeutic Strategies of Pd-L1 Expression in Oral Cancers( I )(1/3)

  Lin, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Catenins 31%

• 組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(2/3)

  Ho, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%