College of Medical Science and Technology

Projects

Projects per year 2010 2022

• 42 Active
• 805 Finished

Projects per year

Search results

• Finished

  老年性聽力損失: Cisd2缺失會加速老化過程中的聽力損傷

  Chen, Y.

  11/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Strategies to Target Long-Lived Plasma Cells for Treating Hemophilia a Inhibitors

  Liu, C.

  9/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Plasma Cells 100%
  • Hemophilia A 70%
  • Stromal Cells 37%
  • Antibody Formation 33%
  • plerixafor octahydrochloride 18%

• 北區高階生醫產業聚落及產業規劃-台灣遠距健康產業聚落發展先導計畫

  Yen, Y. & Chen, R.

  9/1/14 → 8/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Valproate治療腦外傷病人的臨床研究

  Chang, C., Chiang, Y., Liao, K., Yang, S., Wu, C. & Chen, K.

  8/7/14 → 8/6/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Traumatic Brain Injury 100%
  • Valproic Acid 97%
  • Therapeutic Uses 31%
  • Histone Deacetylases 29%
  • Glycogen 26%

• 核糖核甘酸還原酉每抑制劑在人類乳突瘤病毒感染之非小細胞肺癌治療效果評估

  Hsu, N.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Role of Niemann-Pick Type C2 Protein in Liver Cancer

  Liao, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 70%
  • Carcinogenesis 40%
  • Cholesterol 39%
  • Liver 36%

• https://www.grb.gov.tw/search/planDetail?id=8356932&docId=447412

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Malondialdehyde 100%
  • Synovial Fluid 29%
  • Proteins 28%
  • Autoantibodies 17%
  • Rheumatoid Arthritis 15%

• Exploration of RBM4-Regulated Splicing Events in Differentiating Adipocytes by Using Next-Generation Sequencing

  Lin, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • insulin receptors 70%
  • adipocytes 54%
  • adipose tissue 50%
  • adipogenesis 45%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis

  Wu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Galectin 1 100%
  • Neuropilin-1 68%
  • Liver Cirrhosis 28%
  • Platelet-Derived Growth Factor Receptors 20%
  • thiodigalactoside 12%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Investigation on the Epigenetic Regulation of Autophagy

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Autophagy 100%
  • Enhancer of Zeste Homolog 2 Protein 91%
  • GSK343 51%
  • Triple Negative Breast Neoplasms 41%
  • Epigenomics 21%

• The Functional Studies of ZNF179 in Neurons in vitro and in vvo

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Huntington Disease 100%
  • Knockout Mice 82%
  • Spatial Learning 72%
  • Spatial Memory 66%
  • (2-azidomethyl)phenylacetyl 64%

• Building a Cancer Progress Model Based on PPI Network and Gene Expression Changes and Its Applications for Classification of Cancer Subtypes

  Chiu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Gene expression 100%
  • Tumors 46%
  • Proteins 27%
  • Bioinformatics 16%
  • Brain 12%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• Pre-Clinical and Clinical Study for Multi-Nation Intelligent Medication Safety System

  Li, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Decision support systems 100%
  • Security systems 98%
  • Health 71%
  • Automatic identification 58%
  • Health care 49%

• An in Silico Vaccine Design Based on T-Cell Epitope Prediction

  Su, E. C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epitopes 100%
  • T-cells 61%
  • Vaccines 35%
  • Antigens 27%
  • Physicochemical properties 19%

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Genetic Polymorphisms in microRNA and Risk of the Post-Thrombolytic Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hyperglycemia 100%
  • MicroRNAs 92%
  • Stroke 80%
  • Single Nucleotide Polymorphism 42%
  • Small Untranslated RNA 10%

• Analyses of ADAM9 on Integrin b4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • prostatic neoplasms 38%
  • neoplasms 38%

• Investigation on the Suppressive Mechanisms of Novel Anti-Glypican3 Antibody Drugs

  Yang, Y.

  8/1/14 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glypicans 100%
  • Hepatocellular Carcinoma 20%
  • Antibodies 18%
  • Single-Chain Antibodies 10%
  • Heparan Sulfate Proteoglycans 10%

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Colorectal Neoplasms 100%
  • Drug Resistance 38%
  • ras Genes 37%
  • Taiwan 31%
  • Neoplasm Metastasis 25%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • pifithrin 40%
  • Stem Cells 31%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)

  Huang, T.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenomatous Polyposis Coli 100%
  • Colorectal Neoplasms 44%
  • Mutation 34%
  • Drug Resistance 28%
  • Fluorouracil 17%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electric Stimulation 100%
  • Parkinson Disease 98%
  • Neuronal Plasticity 24%
  • Oxidopamine 19%
  • Therapeutics 13%

• Study and Implementation of Patient Privacy Protection under the Framework for Electronic Medical Records Exchange in Taiwan

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electronic medical equipment 100%
  • Data privacy 38%
  • Health insurance 14%
  • Health 13%
  • Virtual private networks 13%

• Prognosis Analysis and Data Mining for Emergency Patients after Arriving Hospital

  Hsu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fires 100%
  • Health insurance 91%
  • Analytic hierarchy process 67%
  • Health care 61%
  • Data mining 50%

• 探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (I)

  Lee, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • beta Catenin 100%
  • Colorectal Neoplasms 78%
  • Wnt Signaling Pathway 55%
  • Adenomatous Polyposis Coli 52%
  • 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide 25%

• Investigation of the Intrinsic Molecular Mechanisms of ETV6 That Contribute to Suppression of Metastasis and Sensitivity of Chemotherapy in Prostate Cancer

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neoplasm Metastasis 28%
  • ras Genes 16%
  • Nuclear Receptor Co-Repressor 2 11%
  • Drug Therapy 11%

• The Role of CCR5/RANTES in Neurodegeneration

  Chou, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chemokine CCL5 100%
  • Neurons 54%
  • CCR5 Receptors 29%
  • Phosphatidylinositol 3-Kinases 29%
  • Glycogen Synthase Kinase 3 beta 26%

• Investigation of the Oncogenic Role of Prohibitin in Breast Cancer Progression

  Huang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Oncogenic 100%
  • Rocaglamide 67%
  • Subcellular Localization 48%
  • Cell Viability 35%
  • Plasma 21%

• The Study of Neurotrophic and Neuroplastic Effects of Exercise and Environmental Enrichment in Mild Traumatic Brain Injury

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nerve Growth Factors 56%
  • Traumatic Brain Injury 51%
  • Exercise 34%
  • Neuropathology 29%
  • Global Health 25%

• Association between Human Endogenous Retrovirus and Cancers Using RNA-Seq Data

  Lee, Y. G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Endogenous Retroviruses 100%
  • RNA-Seq 28%
  • Genome 22%
  • Neoplasms 21%
  • gag Genes 11%

• Identification of Human Viral Micrornas and Its Targets by Using Small RNA Sequencing Data Based on RNA Sequence and Structure Features

  Chang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Forensic Anthropology 14%
  • Databases 13%
  • Viruses 7%
  • Mammals 6%

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tea 100%
  • Nicotine 26%
  • Capsules 23%
  • Breast Neoplasms 23%
  • Smoking 19%

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • Drug Resistance 38%
  • ras Genes 37%
  • Taiwan 31%
  • Neoplasm Metastasis 25%

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structure-Based Design, Synthesis and Biological Evaluation of Novel 6-Substituted 10-Chloro-12h-Thiochromeno[2,3-C]Quinolin-12-One Derivatives as Potential Anticancer Agents

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antineoplastic Agent 100%
  • Intoplicine 80%
  • Molecule 65%
  • Topoisomerase Inhibitor 63%
  • Growth Inhibition 44%

• The Mechanistic Action of DDX3 in Colorectal Tumor Progression

  Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • beta Catenin 100%
  • Catenins 46%
  • Drug Resistance 45%
  • Neoplasms 43%
  • Colorectal Neoplasms 39%

• Dysregulation of Huntingtin-Associated Protein-Mediated Calcium Trafficking in Neurodegenerative Diseases

  Lin, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proto-Oncogene Proteins c-bcr 100%
  • Proteins 89%
  • Huntingtin Protein 71%
  • Neurodegenerative Diseases 63%
  • Kinesin 62%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tetraiodothyroacetic acid 100%
  • Cetuximab 77%
  • Adenomatous Polyposis Coli 38%
  • Colorectal Neoplasms 28%
  • Integrins 16%

• Uncovering the Specific Interactions between DNA Mimic Proteins and Their Target DNA Binding Proteins by Structure-Based Studies

  Wang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • DNA 100%
  • Uracil-DNA Glycosidase 61%
  • Proteins 58%
  • Neisseria 55%
  • DNA-Binding Proteins 44%

• MicroRNA-184在肺腫瘤化和臨床預後之角色

  Lee, H.

  8/1/14 → 7/31/15

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • beta Catenin 90%
  • Lung Neoplasms 58%
  • Carcinogenesis 56%
  • Lung 55%

• 探討黃連素對攝護腺癌細胞對調控上皮細胞與間質細胞轉換之角色與 調控機轉之研究

  Lee, K.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討LncRNA MALAT1 在惡性乳癌幹細胞生成之角色以及pterostilbene 對於透過抑制MALAT1而抑制乳癌幹細胞功能之研究

  Wu, T. A.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital