College of Medical Science and Technology

Projects

Projects per year 2010 2022

• 37 Active
• 810 Finished

Projects per year

Search results

• TMU102-AE1-B16

  Hsieh, C.

  1/1/14 → 12/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Investigation of Host Factors Affecting the Pathogenesis of Enterovirus 71 in Neuron and Non-Returnable Cells

  Lin, J.

  12/1/13 → 11/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Enterovirus 100%
  • Enterovirus Infections 87%
  • Tropism 44%
  • Small Interfering RNA 31%
  • Taiwan 24%

• Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus

  Liu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Staphylococcus aureus 100%
  • virulence 52%
  • immune evasion 23%
  • sepsis (infection) 23%
  • histidine kinase 21%

• Dissection of Synergistic Involvement among Different Guidance Families in Spinal Motor Neuron Development

  Kao, T.

  12/1/13 → 11/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Motor Neurons 97%
  • Netrin-1 88%
  • Netrin Receptors 74%
  • Axons 68%
  • Growth Cones 57%

• A Preclinical and Clinical Trial Evaluation for an in vitro Diagnostic Kit of Endometriosis (II)

  Yang, W.

  12/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Potential Application of the Staphylococcus aureus DNA Mimic Protein Saugi in Combating Human Viral Disease

  Wang, H.

  10/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • DNA 100%
  • Uracil-DNA Glycosidase 92%
  • DNA Repair Enzymes 83%
  • Neisseria 83%
  • Staphylococcus aureus 77%

• TMU102-AE1-B03

  Hsieh, Y.

  10/1/13 → 9/30/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU102-AE1-B01

  Sung, S.

  10/1/13 → 11/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU102-AE1-B12

  Wang, H.

  10/1/13 → 9/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TELEDERMATOLOGY SOLUTIONS THOUGH MOBILE PHONE

  Li, Y.

  9/1/13 → 8/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mongolia 100%
  • health care workers 57%
  • health science 44%
  • information on patients 15%
  • adequate health care 14%

• Novel Strategies to Target Long-Lived Plasma Cells for Treating Hemophilia a Inhibitors

  Liu, C.

  9/1/13 → 8/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺北醫學大學附設醫院之疾病個案收集與建立臺灣人體生物資料庫

  Yen, Y.

  8/27/13 → 12/31/13

  Project: A - Government Institution › f - Other (Funded by Government)

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antibodies 100%
  • Single-Chain Antibodies 93%
  • Anti-Idiotypic Antibodies 60%
  • Diphosphates 47%
  • human RRM2B protein 46%

• Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

  Lee, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood Vessels 100%
  • Embryonic Structures 92%
  • Knockout Mice 77%
  • Spatial Learning 68%
  • BFP ring finger protein 64%

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proteins 100%
  • Proto-Oncogene Proteins c-bcr 55%
  • Neurodegenerative Diseases 47%
  • Microtubules 39%
  • Calcium 37%

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • adipose tissue 84%
  • insulin receptors 78%
  • adipogenesis 75%
  • energy 49%

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 100%
  • Metabolic Networks and Pathways 49%
  • Pancreatic Neoplasms 46%
  • Knockout Mice 45%
  • Insulin Resistance 40%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

  Lee, H.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

  Deng, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • Light 81%
  • Bone Regeneration 64%
  • Inflammation 47%
  • Alveolar Bone Loss 46%

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 17%
  • Autophagic Cell Death 16%
  • Unfolded Protein Response 13%

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • beta Catenin 90%
  • Lung Neoplasms 58%
  • Carcinogenesis 56%
  • Lung 55%

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Papillomavirus Infections 100%
  • Cisplatin 96%
  • Lung 86%
  • Neoplasms 63%
  • Gastropoda 47%

• The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

  Cheng, Y.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 三陰性乳癌周邊微環境之研究平台建立：以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgen 100%
  • Testosterone 31%
  • Signal Transduction 21%
  • Chemopreventive 9%
  • Silencing RNA 8%

• Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care

  Liu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan

  Wang, W.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Genome 100%
  • Linkage 87%
  • Linkage Analysis 79%
  • False Discovery Rate 58%
  • False 33%

• Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

  Sung, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 49%
  • neoplasms 44%
  • neoplasm cells 41%
  • neoplasm progression 39%

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 46%
  • Cholesterol 45%
  • Mitogen-Activated Protein Kinase 1 34%
  • Liver 32%

• Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

  Chiu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proteins 100%
  • Gene expression 99%
  • Proteomics 48%
  • Genomics 37%

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis

  Su, E. C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epitopes 100%
  • Proteins 46%
  • Bioinformatics 24%
  • Cells 16%
  • Binding sites 15%

• Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport

  Hsu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Data mining 100%
  • Health insurance 90%
  • Decision making 87%
  • Analytic hierarchy process 67%
  • Health care 61%

• TMU101-AE1-B67

  Wang, W.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 人類乳突病毒導致肺腫瘤化之可能機轉

  Cheng, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 晶體性關節炎侵蝕骨頭(蝕骨細胞分化)的分子機制

  Liang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 利用行動通訊技術協助西藏地區之醫護人員進行遠距醫療照護之藍圖規畫

  Li, Y.

  5/24/13 → 11/30/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 利用基因微陣列表現圖譜分析大腸直腸癌細胞之基因表現差異尋找具有抗癌效果之藥物及其調控機轉

  Lee, K.

  5/1/13 → 4/30/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 白藜蘆醇對卵巢囊腫和子宮肌瘤細胞增生之影響

  Lin, H.

  5/1/13 → 4/30/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討DNMT抑制劑治療大腸直腸癌之新機轉

  Yang, P.

  5/1/13 → 4/30/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討轉錄因子KLF10 調控NPRA基因表現與發炎的關聯性

  Chang, H.

  5/1/13 → 4/30/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 鼻咽癌細胞Annexin A2誘導樹突狀細胞免疫抑制反應

  Chen, C.

  5/1/13 → 7/31/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 研究miR-96在攝護腺癌轉移之功能與調控機制

  Liu, Y.

  5/1/13 → 4/30/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 血小板富含血漿合併玻尿酸組成物於治療骨關節炎之轉譯研究應用

  Deng, W.

  5/1/13 → 4/30/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• TMU101-AE1-B48

  Pan, S.

  4/1/13 → 3/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 探討樟芝萃取物antrocin在抑制大直腸癌細胞轉移的效用及機制

  Wu, T. A.

  3/1/13 → 2/28/14

  Project: C - Project of Alliance › o - Chi Mei Medical Center