College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2024

• 73 Active
• 1019 Finished

Projects per year

Search results

• 蝦紅素臨床應用劑型開發

  Liu, J.

  6/1/16 → 5/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗癌藥物 ITCH E3 ubiquitin ligase 抑制劑之臨床前新藥開發- ITCH E3 ubiquitin ligase 抑制劑作為抗癌藥物之臨床前新藥開發（3/3）

  Pan, S.

  6/1/16 → 5/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Chen, H.

  7/1/16 → 7/19/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Lo, Y.

  7/1/16 → 7/19/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Lo, Y.

  7/1/16 → 7/19/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Disease trajectories and its association with metabolic dysfunction of prostate cancer men following androgen deprivation therapy and the potential of pharmacological medication in preventing metastatic diseases.(2/3)

  Shao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgens 100%
  • Prostatic Neoplasms 60%
  • Hyperlipidemias 44%
  • Taiwan 32%
  • Metabolic Syndrome 30%

• 研究NPC2蛋白抑制肝細胞增生與癌化的機制(3/3)

  Liao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 52%
  • Carcinogenesis 40%
  • Cholesterol 39%
  • Liver 36%

• A Wearable Device Evaluation for Medication Management in Patients Taking Sleep Medicine via Cloud Platform Development( II )

  Li, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Predicton of MHC binding and antigen processing in T-cell epitope identification(2/2)

  Su, E. C.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epitopes 100%
  • Allergens 83%
  • Vaccines 70%
  • Proteins 47%
  • T-cells 45%

• Potential Therapeutic Effect of Curcumin, a Natural Mtor Inhibitor, in Tuberous Sclerosis Complex

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Curcumin 100%
  • Tuberous Sclerosis 99%
  • TOR Serine-Threonine Kinases 65%
  • Raptors 22%
  • Knockout Mice 20%

• 多維疾病軌跡視覺化研究

  Li, Y.

  8/1/16 → 7/31/17

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 不同表現型之血紅素結合蛋白在缺血性心臟病之功能差異及其重組次單元當缺血性心臟病胜?藥評估

  Cheng, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Wnt Signals and Programmed Cell Death on the Organization of Neural Circuit in Spinal Motor Neurons

  Kao, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Motor Neurons 100%
  • Wnt Receptors 73%
  • Ephrins 46%
  • Nerve Growth Factors 42%
  • Growth Cones 40%

• Effect of Hmga2 in Chemotherapy Response of Colorectal Cancer Patients with Different Apc Status( III )

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using the Integrated Hospital Data for Implementing and Evaluating of Early Detection of Influenza Epidemic

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacological Role of a Novel Dual-Targeting Hdacs/Microtubule Inhibitor 21-277 Inhibits Human Cancer Cells Growth in Vitro and in Vivo

  HuangFu, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antineoplastic Agent 99%
  • Pharmacological Role 34%
  • Protein 23%
  • Growth Inhibition 22%

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer( III )

  Lee, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 99%
  • Peptide Hydrolases 83%
  • Sumoylation 26%
  • Triple Negative Breast Neoplasms 23%

• Constructing an Assessment Model for Outcome after Carotid Stent Using National Health Insurance Database with Validation by Clinical Data

  Chiu, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Carotid Stenosis 82%
  • Stents 62%
  • Databases 58%
  • Health Insurance 51%

• Generate anti-Fibroblast growth factor receptor 2 (FGFR2) antibody drugs and study on their potential application against gastric cancer

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)

  Chuang, J.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 40%
  • Co-Repressor Proteins 25%
  • emerin 24%

• Investigations on the Cellular Mechanisms of Ccl5 in Memory Formation and Its Role in Alzheimer’S Disease

  Chou, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chemokine CCL5 100%
  • Alzheimer Disease 84%
  • Memory 30%
  • Neurons 14%
  • Knockout Mice 11%

• Roles of microRNA96 in TGF-beta-Mediated Tumor Progression(2/3)

  Tsai, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• Mechanisms by Which Enterovirus-Host Interactions Form Viral Replication Organelles and Regulate Viral Replication

  Lin, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Organelles 100%
  • Enterovirus 53%
  • Intracellular Membranes 29%
  • Host Microbial Interactions 29%
  • Membranes 27%

• Characterize the E3 Ligase Activity of Znf179 and Its Effect on the Proteinopathies of TDP-43 Protein(2/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin-Protein Ligases 100%
  • TDP-43 Proteinopathies 61%
  • Amyotrophic Lateral Sclerosis 47%
  • Frontotemporal Lobar Degeneration 36%
  • Proteins 32%

• The Role of EGFR in Prostate Cancer Progression and Combination Therapy(2/3)

  Liu, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • ErbB Receptors 82%
  • Berberis 26%
  • Neoplastic Stem Cells 16%
  • Neoplasms 15%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers(2/3)

  Lin, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Catenins 31%

• Uncovering the Specific Interactions between DNA Mimic Proteins and Their Target DNA Binding Proteins by Structure-Based Studies(3/3)

  Wang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • DNA 100%
  • Uracil-DNA Glycosidase 61%
  • Proteins 58%
  • Neisseria 55%
  • DNA-Binding Proteins 44%

• Establishing the Disease and Genetic Risk Prediction Score of Cognitive Impairment to Early Prevent the Threat of Dementia

  Hsieh, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dementia 100%
  • Neurodegenerative Diseases 80%
  • Iron-Deficiency Anemias 78%
  • Taiwan 65%
  • Cognitive Dysfunction 65%

• The Impacts of Obesity-Associated Alterations in Adipose-Derived Stem Cell on Tumor Development

  Deng, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Obesity 100%
  • Stem Cells 94%
  • Neoplastic Stem Cells 60%
  • Neoplasms 41%
  • Mesenchymal Stem Cells 38%

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells.( II )

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性pan-HDAC 抑制劑抑制血管新生之藥物研發與藥理作用機轉(3/3)

  Pan, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 39%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 20%
  • Animal Models 18%
  • Drug Discovery 17%

• An integrated system for detection and dynamic visualization of copy number aberrations from high-throughput whole-exome sequencing

  Chang, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• 利用解碼大腸癌微型核糖核酸-致癌基因調控網絡

  Cheng, Y.

  8/1/16 → 7/31/17

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Investigate Pathogenic Role of Rheumatoid Arthritis, Sjogren$S Syndrome, Systemic Lupus Erythematosus and Its Combined Syndromes from Post-Translational Modification of Serum Proteins: Study of Malondialdehyde Modification

  Lin, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Malondialdehyde 100%
  • Sjogren's Syndrome 94%
  • Systemic Lupus Erythematosus 54%
  • Autoantibodies 23%
  • Peptides 20%

• ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(3/3)

  Sung, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • neoplasms 38%
  • neoplasm cells 32%

• Identification of Rewired Apc Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer( III )

  Huang, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Electron-Transfer-Flavoprotein Dehydrogenase Mutation on Bioenergetic Metabolism and Muscular Differentiation in Vitro

  Kao, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency 100%
  • Electron-Transferring Flavoproteins 89%
  • Mutation 24%
  • Energy Metabolism 19%
  • Fatty Acids 18%

• The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis(3/3)

  Wu, M.

  8/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Galectin 1 100%
  • Neuropilin-1 68%
  • Liver Cirrhosis 28%
  • Platelet-Derived Growth Factor Receptors 24%
  • thiodigalactoside 12%

• 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討miR-21調控大腸直腸癌細胞TET1/5-hydroxymethylcytosine表現對其化療反應之關聯(3/3)

  Yang, P.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用PLA2G6基因嵌入小鼠研究第十四型帕金森病分子病理機轉與治療(1/3)

  Yeh, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 亨丁頓關聯蛋白與阿伯爾森幫手整合位點蛋白的交互作用在乙型類澱粉引起的神經退化中之角色

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Clinical Outcome and Drug Resistant Biomarkers Establish for Hpv Infected Non-Small Cell Lung Cancer

  Hsu, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lung Neoplasms 100%
  • MicroRNAs 63%
  • TL 1 33%
  • Biomarkers 21%
  • Neoplasms 19%

• Engineering Chimeric Antigen Receptor T-Cells against Immune Checkpoint Inhibitor Pd1 and Pd-L1 for Treating Pancreatic Cancer

  Liu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chimeric Antigen Receptors 100%
  • T-Lymphocytes 34%
  • Pancreatic Neoplasms 29%
  • Neoplasms 17%
  • atezolizumab 9%

• Crystal Structures and Functional Studies of Novel Glycosyltransferases from Staphylococcus aureus(2/3)

  Liu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycosyltransferases 100%
  • Staphylococcus aureus 64%
  • Fibrin 30%
  • Cathepsin G 22%
  • Minisatellite Repeats 19%

• To Study the Role of Sp1 in Cancer Drug Resistance( I )

  Chuang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug Resistance 100%
  • Temozolomide 84%
  • Neoplasms 48%
  • superoxide dismutase 2 40%
  • Reactive Oxygen Species 32%

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different Apc Status( III )

  Lin, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Changes of Brain Structural Connectivity and Behaviors in Typical Autism after Teacch Intervention

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Autistic Disorder 100%
  • Communication 96%
  • Autism Spectrum Disorder 74%
  • Endophenotypes 38%
  • Brain 28%