Additional file 2 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

  • Yu-Wen Cheng (Contributor)
  • Chi Hao Tsai (Contributor)
  • Jau-Der Ho (Contributor)
  • Po Lin Liao (Contributor)
  • Ching-Hao Li (Contributor)
  • Fan Li Lin (Contributor)
  • Yen Ju Chan (Contributor)
  • Ching Yi Chen (Contributor)



Additional file 2: Figure S1. TiO2-NPs did not affect the expression of AJ proteins. Figure S2. TiO2-MPs did not affect the expression of TJ/AJ proteins. Figure S3. Changes in mRNA level of claudin-5, ZO-1 and occludin in TiO22-NP-treated bEnd.3 cells. Figure S4. TiO2-NP activated ADAM17 directly, contributing to rapid claudin-5 protein degradation. Figure S5. Scheme of animal treatment. Figure S6. Reduction of choroid blood flow was evidenced in TiO2-NP-treated mice. Figure S7. Intravitreal exposure of TiO2-NPs changed the thickness of retinal sublayers.
Date made availableJan 1 2021
Publisherfigshare Academic Research System

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